DPM3

Description		dolichyl-phosphate mannosyltransferase subunit 3, regulatory
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Dolichol-phosphate-mannose Synthase Complex
	Molecular Function	Protein Binding Enzyme Activator Activity Endoplasmic Reticulum-plasma Membrane Adaptor Activity
	Biological Process	Protein Glycosylation Protein O-linked Glycosylation Via Mannose Dolichol Phosphate Mannose Biosynthetic Process
Pathways		Synthesis of dolichyl-phosphate mannose Defective DPM1 causes DPM1-CDG Defective DPM3 causes DPM3-CDG Defective DPM2 causes DPM2-CDG
Drugs
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate in non-diabetics ( 31451708) Inflammatory bowel disease ( 28067908) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Prostate cancer ( 23535732) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urate levels ( 31578528) Urinary albumin-to-creatinine ratio ( 31630189)
Interacting Genes		6 interacting genes: DPM1 DPM2 FAM177A1 IER3IP1 SEC22B TMEM147
Entrez ID		54344
HPRD ID		16179
Ensembl ID		ENSG00000179085
Uniprot IDs		A0A140VJI4 Q86TM7 Q9P2X0
PDB IDs
Enriched GO Terms of Interacting Partners?		Dolichol Phosphate Mannose Biosynthetic Process Dolichol-phosphate-mannose Synthase Complex Endoplasmic Reticulum Membrane Dolichol-linked Oligosaccharide Biosynthetic Process GPI Anchor Metabolic Process Isoprenoid Biosynthetic Process Endoplasmic Reticulum GPI Anchor Biosynthetic Process Glycolipid Biosynthetic Process Dolichyl-phosphate Beta-D-mannosyltransferase Activity Glycolipid Metabolic Process Terpenoid Metabolic Process Isoprenoid Metabolic Process Phosphatidylinositol Biosynthetic Process Alcohol Binding Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Phosphatidylinositol Metabolic Process Protein Glycosylation Macromolecule Glycosylation Protein Localization To Nuclear Inner Membrane Positive Regulation Of Extracellular Matrix Constituent Secretion Glycosylation Glycerophospholipid Biosynthetic Process Membrane Lipid Metabolic Process Phospholipid Biosynthetic Process Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Regulation Of Extracellular Matrix Constituent Secretion Glycerophospholipid Metabolic Process Multi-pass Transmembrane Protein Insertion Into ER Membrane Multi-pass Translocon Complex Type B Pancreatic Cell Differentiation Protein O-linked Glycosylation Via Mannose GDP-mannose Metabolic Process Golgi Vesicle Transport Negative Regulation Of Autophagosome Assembly Glycerolipid Metabolic Process Protein Localization To Nuclear Envelope Phospholipid Metabolic Process Enteroendocrine Cell Differentiation Insulin Metabolic Process Establishment Of Protein Localization Regulation Of Fibroblast Apoptotic Process Protein N-linked Glycosylation Via Asparagine D-mannose Binding Positive Regulation Of Extracellular Matrix Organization Enzyme Regulator Activity Carbohydrate Derivative Biosynthetic Process Protein Insertion Into ER Membrane Cellular Localization Lipid Biosynthetic Process
Tagcloud ?