DPM3 and IER3IP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DPM3	IER3IP1
Description		dolichyl-phosphate mannosyltransferase subunit 3, regulatory	immediate early response 3 interacting protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Dolichol-phosphate-mannose Synthase Complex	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane COPII-coated ER To Golgi Transport Vesicle
	Molecular Function	Protein Binding Enzyme Activator Activity Endoplasmic Reticulum-plasma Membrane Adaptor Activity	Protein Binding
	Biological Process	Protein Glycosylation Protein O-linked Glycosylation Via Mannose Dolichol Phosphate Mannose Biosynthetic Process	Type B Pancreatic Cell Differentiation Positive Regulation Of Extracellular Matrix Constituent Secretion Chromatin Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Brain Development Negative Regulation Of Cell Population Proliferation Gene Expression Protein Transport Organ Growth Glucose Homeostasis Negative Regulation Of Apoptotic Process Cell Maturation Positive Regulation Of Protein Secretion Insulin Metabolic Process Regulation Of Fibroblast Apoptotic Process
Pathways		Synthesis of dolichyl-phosphate mannose Defective DPM1 causes DPM1-CDG Defective DPM3 causes DPM3-CDG Defective DPM2 causes DPM2-CDG
Drugs
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate in non-diabetics ( 31451708) Inflammatory bowel disease ( 28067908) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Prostate cancer ( 23535732) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urate levels ( 31578528) Urinary albumin-to-creatinine ratio ( 31630189)	Fruit consumption ( 32066663)
Interacting Genes		6 interacting genes: DPM1 DPM2 FAM177A1 IER3IP1 SEC22B TMEM147	43 interacting genes: AIG1 C19orf18 CDIPT CERS2 CERS4 CSNK2B CST1 DPM3 EBP ELOVL4 ERMP1 FAM210B FCER1G GJB1 GOSR2 GPR42 HERPUD2 JAGN1 KCNA1 MOSPD3 PEX12 PIGP PLP1 POMK RGS2 SCN3B SLC30A4 TK1 TM4SF18 TMEM128 TMEM14A TMEM14B TMEM167A TMEM237 TMEM258 TMEM80 TMEM86B TMPPE TMX2 TRHR UBQLN1 YIPF4 ZFYVE27
Entrez ID		54344	51124
HPRD ID		16179	13727
Ensembl ID		ENSG00000179085	ENSG00000134049
Uniprot IDs		A0A140VJI4 Q86TM7 Q9P2X0	Q9Y5U9
PDB IDs
Enriched GO Terms of Interacting Partners?		Dolichol Phosphate Mannose Biosynthetic Process Dolichol-phosphate-mannose Synthase Complex Endoplasmic Reticulum Membrane Dolichol-linked Oligosaccharide Biosynthetic Process GPI Anchor Metabolic Process Isoprenoid Biosynthetic Process Endoplasmic Reticulum GPI Anchor Biosynthetic Process Glycolipid Biosynthetic Process Dolichyl-phosphate Beta-D-mannosyltransferase Activity Glycolipid Metabolic Process Terpenoid Metabolic Process Isoprenoid Metabolic Process Phosphatidylinositol Biosynthetic Process Alcohol Binding Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Phosphatidylinositol Metabolic Process Protein Glycosylation Macromolecule Glycosylation Protein Localization To Nuclear Inner Membrane Positive Regulation Of Extracellular Matrix Constituent Secretion Glycosylation Glycerophospholipid Biosynthetic Process Membrane Lipid Metabolic Process Phospholipid Biosynthetic Process Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Regulation Of Extracellular Matrix Constituent Secretion Glycerophospholipid Metabolic Process Multi-pass Transmembrane Protein Insertion Into ER Membrane Multi-pass Translocon Complex Type B Pancreatic Cell Differentiation Protein O-linked Glycosylation Via Mannose GDP-mannose Metabolic Process Golgi Vesicle Transport Negative Regulation Of Autophagosome Assembly Glycerolipid Metabolic Process Protein Localization To Nuclear Envelope Phospholipid Metabolic Process Enteroendocrine Cell Differentiation Insulin Metabolic Process Establishment Of Protein Localization Regulation Of Fibroblast Apoptotic Process Protein N-linked Glycosylation Via Asparagine D-mannose Binding Positive Regulation Of Extracellular Matrix Organization Enzyme Regulator Activity Carbohydrate Derivative Biosynthetic Process Protein Insertion Into ER Membrane Cellular Localization Lipid Biosynthetic Process	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding Lipid Biosynthetic Process Sphingosine N-acyltransferase Activity Membrane Lipid Metabolic Process Lipid Metabolic Process Response To Endoplasmic Reticulum Stress
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