HSFY2 and TBX6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HSFY2	TBX6
Description		heat shock transcription factor Y-linked 2	T-box transcription factor 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol	Chromatin Nucleus
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Mesoderm Formation Cell Fate Specification Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Mesoderm Development Mesodermal Cell Fate Specification Anatomical Structure Morphogenesis Negative Regulation Of Neuron Projection Development Negative Regulation Of Neuron Maturation Signal Transduction Involved In Regulation Of Gene Expression Somite Rostral/caudal Axis Specification Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways			Formation of paraxial mesoderm Somitogenesis Formation of the posterior neural plate
Drugs
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Eosinophil count ( 27863252 32888494) Hematocrit ( 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Menarche (age at onset) ( 25231870) Multiple sclerosis ( 31604244) Red blood cell count ( 29403010 27863252 32888494) Reticulocyte count ( 32888494) Schizophrenia ( 29483656 25056061) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		9 interacting genes: ATXN1 BPIFA1 CCNK DTX2 GCM2 NFYC OTUD7B TBX6 TOX2	39 interacting genes: ACTMAP C10orf55 C1orf94 CRX CYSRT1 DAZAP2 HSFY1 HSFY2 INTS11 KLHDC7B KRTAP11-1 KRTAP13-1 KRTAP6-2 KRTAP6-3 MAGED1 MEOX2 METTL27 MGAT5B PLA2G10 POU2AF1 POU6F2 PRMT1 PRR20A PRR20B PRR20C PRR20D PRR20E PSMA3 RBPMS TBX15 TBX19 TCP11L1 TENT5B TLE5 TOX4 TSC1 USP54 YPEL3 ZNF34
Entrez ID		159119	6911
HPRD ID		13680	03888
Ensembl ID		ENSG00000169953	ENSG00000149922
Uniprot IDs		Q96LI6	O95947
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding Regulation Of RNA Metabolic Process Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Cyclin K-CDK13 Complex Cyclin K-CDK12 Complex Immune Response In Nasopharyngeal-associated Lymphoid Tissue Negative Regulation Of Single-species Biofilm Formation In Or On Host Organism DNA-templated Transcription Negative Regulation Of Neuron Maturation Positive Regulation Of Macromolecule Metabolic Process POZ Domain Binding Immune Response In Gut-associated Lymphoid Tissue Nucleus Regulation Of Gene Expression CCAAT-binding Factor Complex Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Gliogenesis Parathyroid Gland Development Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Poly(G) Binding Mesodermal Cell Fate Specification Cyclin/CDK Positive Transcription Elongation Factor Complex Positive Regulation Of TORC2 Signaling Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Neuron Maturation Intracellular Phosphate Ion Homeostasis Somite Rostral/caudal Axis Specification RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Protein K11-linked Deubiquitination Regulation Of Macromolecule Metabolic Process Nuclear Inclusion Body Cyclin-dependent Protein Serine/threonine Kinase Activator Activity Host-mediated Suppression Of Viral Genome Replication Regulation Of TORC2 Signaling
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