RNF181 and ELL2

Number of citations of the paper that reports this interaction (PubMedID 26398855)
0

Data Source:
BioGRID (two hybrid)

		RNF181	ELL2
Description		ring finger protein 181	elongation factor for RNA polymerase II 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Nucleus Nucleoplasm Transcription Elongation Factor Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Cis-regulatory Region Sequence-specific DNA Binding Protein Binding
	Biological Process	Protein Ubiquitination Protein Autoubiquitination	Transcription Elongation By RNA Polymerase II Positive Regulation Of Transcription Elongation By RNA Polymerase II SnRNA Transcription By RNA Polymerase II
Pathways		E3 ubiquitin ligases ubiquitinate target proteins	RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes
Drugs
Diseases
GWAS		Prostate cancer ( 21743467)	Albumin-globulin ratio ( 29403010) B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Body mass index ( 26426971) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) IgA levels ( 28628107) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392) IgG sialylation phenotypes (multivariate analysis) ( 28878392) Mean corpuscular hemoglobin ( 32888494) Multiple myeloma ( 26007630 33875642) Multiple myeloma and monoclonal gammopathy ( 26007630) Non-albumin protein levels ( 29403010) Serum total protein levels ( 23022100) Telomere length ( 30185882)
Interacting Genes		32 interacting genes: ALB BCL10 BIRC2 BTG1 CARD11 CLK4 ELL2 FGB HBA1 MCM7 MRPS6 MT1E MT1H NDUFB10 NPY5R PEG10 RBCK1 RPL5 SFMBT2 TRIM24 TRIM8 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2U VPS11 ZMYND10	7 interacting genes: AQP2 CASK EAF1 EXOC8 PRKAB2 RNF181 SIAH1
Entrez ID		51255	22936
HPRD ID		14236	11798
Ensembl ID		ENSG00000168894	ENSG00000118985
Uniprot IDs		Q9P0P0	O00472 Q59FW6
PDB IDs			2E5N 5JW9 7OKX 7OKY
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Post-translational Protein Modification Protein K48-linked Ubiquitination Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Activity Proteolysis Involved In Protein Catabolic Process Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Metabolic Process Protein Monoubiquitination Positive Regulation Of Protein Polyubiquitination Proteolysis Transferase Activity Protein K63-linked Ubiquitination Positive Regulation Of NF-kappaB Transcription Factor Activity Catabolic Process Regulation Of Protein Polyubiquitination Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Protein Ubiquitination CBM Complex Positive Regulation Of Protein Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of DNA-binding Transcription Factor Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Post-translational Protein Modification Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Post-translational Protein Modification Protein Catabolic Process Regulation Of Intracellular Signal Transduction ATP Binding Transcription Coactivator Activity Canonical NF-kappaB Signal Transduction Nucleotide Binding Macromolecule Metabolic Process Proteasomal Protein Catabolic Process TORC1 Signaling Detoxification Of Copper Ion Nucleus Regulation Of Protein K63-linked Ubiquitination CARD Domain Binding Regulation Of DNA-binding Transcription Factor Activity Protein-containing Complex TOR Signaling Regulation Of Signal Transduction
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