RNF181 and BTG1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		RNF181	BTG1
Description		ring finger protein 181	BTG anti-proliferation factor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Transcription Coregulator Activity Protein Binding Enzyme Binding Kinase Binding
	Biological Process	Protein Ubiquitination Protein Autoubiquitination	Regulation Of DNA-templated Transcription Response To Oxidative Stress Spermatogenesis Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Cell Migration Negative Regulation Of Cell Growth Response To Peptide Hormone Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Fibroblast Apoptotic Process
Pathways		E3 ubiquitin ligases ubiquitinate target proteins	FOXO-mediated transcription of cell cycle genes
Drugs
Diseases
GWAS		Prostate cancer ( 21743467)	Heart failure ( 20445134) Metabolite levels ( 23823483) Schizophrenia ( 28991256 29483656 30285260)
Interacting Genes		32 interacting genes: ALB BCL10 BIRC2 BTG1 CARD11 CLK4 ELL2 FGB HBA1 MCM7 MRPS6 MT1E MT1H NDUFB10 NPY5R PEG10 RBCK1 RPL5 SFMBT2 TRIM24 TRIM8 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2U VPS11 ZMYND10	16 interacting genes: CCNA2 CDKN2D CNOT7 CNOT8 FADD GRB2 HOXB9 NCK2 PRMT1 RARA RNF181 SKP2 THRA THRB TUBA1A XRCC6
Entrez ID		51255	694
HPRD ID		14236	15912
Ensembl ID		ENSG00000168894	ENSG00000133639
Uniprot IDs		Q9P0P0	P62324 Q6IBC8
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Post-translational Protein Modification Protein K48-linked Ubiquitination Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Activity Proteolysis Involved In Protein Catabolic Process Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Metabolic Process Protein Monoubiquitination Positive Regulation Of Protein Polyubiquitination Proteolysis Transferase Activity Protein K63-linked Ubiquitination Positive Regulation Of NF-kappaB Transcription Factor Activity Catabolic Process Regulation Of Protein Polyubiquitination Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Protein Ubiquitination CBM Complex Positive Regulation Of Protein Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of DNA-binding Transcription Factor Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Post-translational Protein Modification Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Post-translational Protein Modification Protein Catabolic Process Regulation Of Intracellular Signal Transduction ATP Binding Transcription Coactivator Activity Canonical NF-kappaB Signal Transduction Nucleotide Binding Macromolecule Metabolic Process Proteasomal Protein Catabolic Process TORC1 Signaling Detoxification Of Copper Ion Nucleus Regulation Of Protein K63-linked Ubiquitination CARD Domain Binding Regulation Of DNA-binding Transcription Factor Activity Protein-containing Complex TOR Signaling Regulation Of Signal Transduction	Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Positive Regulation Of RNA Metabolic Process Female Courtship Behavior Positive Regulation Of Macromolecule Metabolic Process Retinoic Acid Receptor Signaling Pathway Nucleobase-containing Compound Metabolic Process Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulator Complex Regulation Of Nucleobase-containing Compound Metabolic Process Thyroid Hormone Binding Positive Regulation Of Lymphocyte Activation MRNA Transcription By RNA Polymerase II Regulation Of Thyroid Hormone Receptor Signaling Pathway CCR4-NOT Core Complex Protein-containing Complex Binding Macromolecule Metabolic Process Nuclear Receptor Activity Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Activation MRNA Transcription Regulation Of Female Receptivity Female Mating Behavior Regulation Of Protein Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Translation Type I Pneumocyte Differentiation Regulation Of RNA Metabolic Process DNA-templated Transcription Protein Domain Specific Binding Poly(A)-specific Ribonuclease Activity Cytosol Chromatin DNA Binding Regulation Of Lymphocyte Activation Positive Regulation Of T Cell Activation CCR4-NOT Complex Nucleobase-containing Compound Biosynthetic Process Gland Development Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Leukocyte Cell-cell Adhesion Nuclear Receptor-mediated Signaling Pathway
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