RNF181 and CLK4

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		RNF181	CLK4
Gene Name		ring finger protein 181	CDC-like kinase 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component		Nucleus
	Molecular Function	Ubiquitin-protein Transferase Activity Zinc Ion Binding Ligase Activity	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity ATP Binding
	Biological Process	Protein Autoubiquitination	Peptidyl-tyrosine Phosphorylation Regulation Of RNA Splicing Protein Autophosphorylation
Pathways
Drugs
Diseases
GWAS		Prostate cancer ( 21743467)
Protein-Protein Interactions		19 interactors: BIRC2 BTG1 CLK4 MRPS6 NPY5R PEG10 RBCK1 TRIM24 TRIM8 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2U VPS11 ZMYND10	10 interactors: CLASRP HSPB2 KPNA1 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 RNF181 SRPK1 UBL5
Entrez ID		51255	57396
HPRD ID		14236	12140
Ensembl ID			ENSG00000113240
Uniprot IDs		Q9P0P0	Q9HAZ1
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K48-linked Ubiquitination Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Toll-like Receptor 4 Signaling Pathway Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Cellular Protein Modification Process Activation Of Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Cellular Macromolecule Catabolic Process Cellular Protein Metabolic Process Positive Regulation Of Innate Immune Response Protein K11-linked Ubiquitination Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Immune Response-regulating Signaling Pathway Regulation Of Innate Immune Response Cellular Response To Oxygen Levels Response To Hypoxia Catabolic Process Positive Regulation Of Protein Ubiquitination Protein Metabolic Process Positive Regulation Of Immune Response Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteolysis Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Innate Immune Response Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Ligase Activity Negative Regulation Of Necroptotic Process	RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing
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