GATA3 and HDAC2

Number of citations of the paper that reports this interaction (PubMedID 31409898)
53

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology)

		GATA3	HDAC2
Description		GATA binding protein 3	histone deacetylase 2
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Histone Deacetylase Complex Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Cytoplasm NuRD Complex Protein-containing Complex ESC/E(Z) Complex Sin3-type Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding Transcription Coactivator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Interleukin-2 Receptor Binding Protein Binding Zinc Ion Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding HMG Box Domain Binding Histone Methyltransferase Binding Sequence-specific Double-stranded DNA Binding	Transcription Coregulator Binding Chromatin Binding RNA Binding Histone Deacetylase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Deacetylase Activity Enzyme Binding Heat Shock Protein Binding Nucleosomal DNA Binding Protein Lysine Deacetylase Activity Histone Binding Histone Deacetylase Binding NF-kappaB Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding Histone Deacetylase Activity, Hydrolytic Mechanism Protein Decrotonylase Activity Histone Decrotonylase Activity Protein De-2-hydroxyisobutyrylase Activity Protein Lysine Delactylase Activity Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis In Utero Embryonic Development Cell Fate Determination Neuron Migration Cell Activation Type IV Hypersensitivity Regulation Of Cytokine Production Positive Regulation Of Cytokine Production Kidney Development Mesonephros Development Lens Development In Camera-type Eye Immune System Process Immune System Development Pro-T Cell Differentiation Aortic Valve Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Septum Development Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Defense Response Inflammatory Response Humoral Immune Response Signal Transduction Nervous System Development Axon Guidance Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Male Gonad Development Response To Xenobiotic Stimulus Response To Virus Anatomical Structure Morphogenesis Post-embryonic Development Positive Regulation Of Signal Transduction Response To Gamma Radiation Gene Expression Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Neuron Projection Development Cell Differentiation Neuron Differentiation T Cell Differentiation Erythrocyte Differentiation Macrophage Differentiation Regulation Of Epithelial Cell Differentiation TOR Signaling Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-5 Production T Cell Differentiation In Thymus Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Embryonic Hemopoiesis Cellular Response To Interferon-alpha Ureter Maturation Parathyroid Hormone Secretion Norepinephrine Biosynthetic Process Inner Ear Morphogenesis Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Neuron Apoptotic Process Ear Development Response To Estrogen Thymic T Cell Selection T-helper 2 Cell Differentiation Innate Immune Response Cell Fate Commitment Response To Ethanol Positive Regulation Of T Cell Differentiation Positive Regulation Of Cell Differentiation Regulation Of T-helper Cell Differentiation Negative Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Sympathetic Nervous System Development Thymus Development Embryonic Organ Development Developmental Growth Anatomical Structure Formation Involved In Morphogenesis System Development Homeostasis Of Number Of Cells Negative Regulation Of Inflammatory Response Regulation Of Developmental Process T Cell Receptor Signaling Pathway Cartilage Development Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Parathyroid Gland Development Pharyngeal System Development Uterus Development Canonical Wnt Signaling Pathway Mesenchymal To Epithelial Transition Mast Cell Differentiation Ureteric Bud Formation Cellular Response To Cytokine Stimulus Cellular Response To Interleukin-4 Cellular Response To Tumor Necrosis Factor Otic Vesicle Development Cellular Response To BMP Stimulus Positive Regulation Of Ureteric Bud Formation Nephric Duct Morphogenesis Nephric Duct Formation Regulation Of Nephron Tubule Epithelial Cell Differentiation Ureter Morphogenesis Lymphocyte Migration Cochlea Development Positive Regulation Of MiRNA Transcription Regulation Of Establishment Of Cell Polarity Negative Regulation Of Cell Motility Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of T-helper 2 Cell Cytokine Production Negative Regulation Of Cell Proliferation Involved In Mesonephros Development Positive Regulation Of Thyroid Hormone Generation Positive Regulation Of Transcription Regulatory Region DNA Binding Regulation Of Cellular Response To X-ray Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Involved In Ureteric Bud Formation Negative Regulation Of Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Involved In Ureteric Bud Formation	Negative Regulation Of Transcription By RNA Polymerase II Response To Amphetamine Cardiac Muscle Hypertrophy Chromatin Organization Chromatin Remodeling Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Epidermal Cell Differentiation Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transcription By Competitive Promoter Binding Negative Regulation Of Neuron Projection Development Dendrite Development Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Caffeine Heterochromatin Formation Response To Lipopolysaccharide Positive Regulation Of Interleukin-1 Production Positive Regulation Of Tumor Necrosis Factor Production Circadian Regulation Of Gene Expression Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cellular Response To Heat Response To Nicotine Protein Modification Process Response To Cocaine Odontogenesis Of Dentin-containing Tooth Regulation Of Cell Fate Specification Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Positive Regulation Of Proteolysis Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Behavioral Response To Ethanol Rhythmic Process Positive Regulation Of Oligodendrocyte Differentiation Progesterone Receptor Signaling Pathway Response To Hyperoxia Hair Follicle Placode Formation Negative Regulation Of Dendritic Spine Development Eyelid Development In Camera-type Eye Fungiform Papilla Formation Cellular Response To Hydrogen Peroxide Cellular Response To Retinoic Acid Cellular Response To Transforming Growth Factor Beta Stimulus Response To Alcohol Positive Regulation Of Male Mating Behavior Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance Cellular Response To Dopamine Response To Amyloid-beta Regulation Of Stem Cell Differentiation
Pathways		Ub-specific processing proteases Interleukin-4 and Interleukin-13 signaling RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Formation of the nephric duct Factors involved in megakaryocyte development and platelet production Developmental Lineage of Mammary Stem Cells	p75NTR negatively regulates cell cycle via SC1 NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression SUMOylation of chromatin organization proteins Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Regulation of MECP2 expression and activity MECP2 regulates neuronal receptors and channels FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes EGR2 and SOX10-mediated initiation of Schwann cell myelination EGR2 and SOX10-mediated initiation of Schwann cell myelination Potential therapeutics for SARS STAT3 nuclear events downstream of ALK signaling Negative Regulation of CDH1 Gene Transcription Factors involved in megakaryocyte development and platelet production Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Drugs			Pravastatin Lovastatin Theophylline Valproic acid Valproic acid Simvastatin Atorvastatin Fluvastatin Aminophylline Decitabine Oxtriphylline Vorinostat Vorinostat Belinostat Pracinostat Romidepsin Romidepsin Panobinostat Phenylbutyric acid Tixocortol Mocetinostat Entinostat Abexinostat Givinostat Pyroxamide
Diseases
GWAS		Acute lymphoblastic leukemia (adolescents and young adults) ( 25468567) Acute lymphoblastic leukemia (B-cell precursor) ( 29296818 23996088) Acute lymphoblastic leukemia in childhood (B cell precursor) ( 29632299) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 31361310 30013184) Allergy ( 27182965) Asthma ( 34103634 29273806 27182965 30929738 32296059 31361310 31619474 31959851) Asthma (adult onset) ( 30929738 31036433) Asthma (childhood onset) ( 30929738 31036433) Asthma (moderate or severe) ( 30552067) Asthma or allergic disease (pleiotropy) ( 29785011) Autoimmune traits (pleiotropy) ( 30572963) B cell acute lymphoblastic leukaemia (abnormal cytogenetics) ( 29296818) B cell acute lymphoblastic leukaemia (hyperdiploid negative) ( 29296818) B cell acute lymphoblastic leukaemia (normal cytogenetics) ( 29296818) B cell acute lymphoblastic leukaemia (Philadelphia chromosome negative) ( 29296818) B cell acute lymphoblastic leukaemia in adulthood ( 29296818) B cell acute lymphoblastic leukaemia in young adulthood ( 29296818) B-cell acute lymphoblastic leukaemia ( 31767839) Basal cell carcinoma ( 25855136 27539887) Benign prostatic hyperplasia and/or lower urinary tract symptoms ( 28656603) Calcium levels ( 24068962) Colorectal cancer ( 30529582 28869801 25990418 24737748 31826910) Colorectal cancer (diet interaction) ( 24743840) Colorectal cancer or advanced adenoma ( 30510241) Craniofacial microsomia ( 26853712) Eosinophil count ( 27863252 32888494) Eosinophil percentage of white cells ( 32888494) Fasting glucose change (short-term) ( 31263163) General risk tolerance (MTAG) ( 30643258) Glycemic traits (pleiotropy) ( 31021400) Hair shape ( 29220522) Hodgkin's lymphoma ( 29196614 24920014 21037568) Intracranial aneurysm ( 29531279) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mild influenza (H1N1) infection ( 26379185) Multiple sclerosis ( 31604244) Nasal polyps ( 30643255) Neutrophil percentage of white cells ( 32888494) Nodular sclerosis Hodgkin lymphoma ( 29196614) Obstetric antiphospholipid syndrome ( 28424481) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Plasma parathyroid hormone levels ( 30134803) Recalcitrant atopic dermatitis ( 25935106) Rheumatoid arthritis ( 23143596 30572963 24390342 30423114) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Scalp hair shape ( 26926045) Selective IgA deficiency ( 27723758) Self-reported allergy ( 23817569) Smoking status (ever vs never smokers) ( 30643258) Stroke ( 26089329) Systemic lupus erythematosus ( 26502338) Takayasu arteritis ( 25604533) Thyroid stimulating hormone levels ( 30367059) Type 1 diabetes ( 31152121 34012112)	Event free survival in diffuse large B-cell lymphoma treated with immunochemotherapy ( 26460308) Metabolite levels ( 23823483)
Interacting Genes		33 interacting genes: ACTN2 CDK2 CYSRT1 ETS1 ETS2 FBXW7 HDAC2 HDAC3 HIF1A KDM1A KRTAP12-1 KRTAP13-2 KRTAP6-2 KRTAP6-3 LCK LMO1 LMO2 MAPK14 MED1 NFIA NFIB NFIC PLEKHG4 PSMA3 RARB REPIN1 SATB1 SP1 SPI1 TAL1 TRIM55 TRIM63 ZFPM2	97 interacting genes: ANTXR1 APPL1 ARID4A AURKA BRCA1 BRMS1 BRMS1L BUB3 CDC20 CDH1 CDKN1A CDYL CEBPA CHFR CIRSR CSNK2A1 CSNK2A2 CTBP1 CUL4B CYTOR DAXX DDX20 DMAP1 DNMT1 DNMT3B EED EID2 ERCC6 FKBP3 GATA3 H2AC1 H2AC20 H2BC21 H3-4 H3C1 HDAC1 HDAC10 HDAC7 HIF1A HIF1AN HOPX IFRD1 IKZF1 IKZF4 ING1 JUP MAD1L1 MBD2 MTA1 MXD1 NACC2 NRIP1 PA2G4 PADI4 PHB2 PHF21A PIAS4 PML PPARD PPP1R8 PTMA RBBP4 RBBP7 RBP1 RCOR1 RELA RFX5 RUNX3 SALL1 SAP30 SETDB1 SIN3A SMAD2 SMARCA5 SMYD1 SNW1 SP1 SP3 SPEN SS18L1 STAT3 SUMO2 SUV39H1 SYK TFCP2 THRA THRB TMEM132D TOP2A TOP2B TP53 UBC USP4 VHL YY1 ZBTB16 ZNF461
Entrez ID		2625	3066
HPRD ID		00572	05521
Ensembl ID		ENSG00000107485	ENSG00000196591
Uniprot IDs		P23771	Q92769
PDB IDs		4HC7 4HC9 4HCA	3MAX 4LXZ 4LY1 5IWG 5IX0 6G3O 6WBW 6WBZ 6WHN 6WHO 6WHQ 6WHZ 6WI3 6XDM 6XEB 6XEC 7JS8 7KBG 7KBH 7LTG 7LTK 7LTL 7MOS 7MOT 7MOX 7MOY 7MOZ 7ZZO 7ZZP 7ZZR 7ZZS 7ZZT 7ZZU 7ZZW 8A0B 8BPA 8BPB 8BPC 8C60 9DTQ
Enriched GO Terms of Interacting Partners?		RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Erythrocyte Differentiation Chromatin DNA-binding Transcription Factor Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Nucleoplasm Negative Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Gene Expression DNA-binding Transcription Factor Activity Regulation Of Macromolecule Biosynthetic Process Histone Deacetylase Binding Regulation Of Myeloid Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Neural Precursor Cell Proliferation Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Protein De-2-hydroxyisobutyrylase Activity Positive Regulation Of Myeloid Cell Differentiation Regulation Of Cell Population Proliferation Regulation Of Hemopoiesis Regulation Of Macromolecule Metabolic Process Generation Of Neurons Positive Regulation Of Chromatin Organization Protein Lysine Delactylase Activity Sequence-specific DNA Binding Positive Regulation Of Blood Vessel Endothelial Cell Migration Embryonic Hemopoiesis Protein Binding Regulation Of Metabolic Process Nucleus	Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Nucleus Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Nucleoplasm Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Chromatin Remodeling DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Transcription Corepressor Activity Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Sin3-type Complex Histone Deacetylase Binding Chromatin Binding Positive Regulation Of Metabolic Process Regulation Of Developmental Process Positive Regulation Of Macromolecule Biosynthetic Process Histone Deacetylase Complex Positive Regulation Of Biosynthetic Process Positive Regulation Of Developmental Process Negative Regulation Of Stem Cell Population Maintenance RNA Polymerase II-specific DNA-binding Transcription Factor Binding Epigenetic Regulation Of Gene Expression Negative Regulation Of Gene Expression Transcription Repressor Complex Negative Regulation Of Developmental Process Negative Regulation Of Gene Expression, Epigenetic Heterochromatin Formation Protein-containing Complex RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Cell Differentiation
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