GATA3 and LMO1

Number of citations of the paper that reports this interaction (PMID 9020185)
15

Data Source:
HPRD (in vitro)

		GATA3	LMO1
Gene Name		GATA binding protein 3	LIM domain only 1 (rhombotin 1)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Nucleolus	Nucleus
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Core Promoter Proximal Region Sequence-specific DNA Binding Core Promoter Sequence-specific DNA Binding Nucleic Acid Binding Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Enhancer Sequence-specific DNA Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Interleukin-2 Receptor Binding Protein Binding Transcription Factor Binding Zinc Ion Binding Transcription Regulatory Region DNA Binding Protein Dimerization Activity E-box Binding HMG Box Domain Binding	Zinc Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Cell Fate Determination Neuron Migration Type IV Hypersensitivity Kidney Development Mesonephros Development Lens Development In Camera-type Eye Pro-T Cell Differentiation Aortic Valve Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Septum Development Transcription From RNA Polymerase II Promoter Defense Response Humoral Immune Response Signal Transduction Axon Guidance Blood Coagulation Negative Regulation Of Cell Proliferation Male Gonad Development Response To Virus Anatomical Structure Morphogenesis Post-embryonic Development Positive Regulation Of Signal Transduction Response To Gamma Radiation Positive Regulation Of Endothelial Cell Migration Regulation Of Neuron Projection Development Phosphatidylinositol 3-kinase Signaling Erythrocyte Differentiation TOR Signaling Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-4 Production Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Embryonic Hemopoiesis Cellular Response To Interferon-alpha Ureter Maturation Parathyroid Hormone Secretion Regulation Of Cytokine Biosynthetic Process Norepinephrine Biosynthetic Process Inner Ear Morphogenesis Response To Drug Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Neuron Apoptotic Process Ear Development Response To Estrogen Thymic T Cell Selection T-helper 2 Cell Differentiation Innate Immune Response Response To Ethanol Positive Regulation Of T Cell Differentiation Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Maturation Sympathetic Nervous System Development Thymus Development Developmental Growth Anatomical Structure Formation Involved In Morphogenesis Negative Regulation Of Inflammatory Response T Cell Receptor Signaling Pathway Regulation Of Histone H3-K4 Methylation Positive Regulation Of Protein Kinase B Signaling Parathyroid Gland Development Pharyngeal System Development Uterus Development Mesenchymal To Epithelial Transition Mast Cell Differentiation Ureteric Bud Formation Regulation Of Histone H3-K27 Methylation Canonical Wnt Signaling Pathway Involved In Metanephric Kidney Development Cellular Response To Interleukin-4 Cellular Response To Tumor Necrosis Factor Otic Vesicle Development Cellular Response To BMP Stimulus Positive Regulation Of Ureteric Bud Formation Nephric Duct Morphogenesis Nephric Duct Formation Regulation Of Nephron Tubule Epithelial Cell Differentiation Interleukin-4 Secretion Interferon-gamma Secretion Lymphocyte Migration Regulation Of Establishment Of Cell Polarity Negative Regulation Of Cell Motility Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Cell Proliferation Involved In Mesonephros Development Positive Regulation Of Thyroid Hormone Generation Positive Regulation Of Interleukin-5 Secretion Positive Regulation Of Interleukin-13 Secretion Positive Regulation Of Transcription Regulatory Region DNA Binding Regulation Of Cellular Response To X-ray Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Involved In Ureteric Bud Formation Negative Regulation Of Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Involved In Ureteric Bud Formation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Hodgkin's lymphoma ( 21037568)	Alcohol consumption ( 23743675) Fasting glucose-related traits (interaction with BMI) ( 22581228) Neuroblastoma ( 22941191 21124317)
Protein-Protein Interactions		13 interactors: ETS1 ETS2 LMO1 LMO2 MED1 PSMA3 RARB REPIN1 SATB1 SP1 SPI1 TAL1 ZFPM2	38 interactors: ADAMTSL4 AES BCL11A BLZF1 CARD9 CDCA7L CDX4 CEP170P1 CEP44 ERBB2IP FAM154A FAM208B GABPB1 GATA3 GOLGA2 IKZF3 KANK2 KRT40 LDB1 LPXN LYL1 LZTS2 NHLH1 NUTM1 PHC2 PTPN3 RBBP8 REL SNTA1 SOX5 SPERT TAL1 TAL2 TCF4 TFIP11 TRIM27 ZBTB43 ZNF219
Entrez ID		2625	4004
HPRD ID		00572	01738
Ensembl ID		ENSG00000107485	ENSG00000166407
Uniprot IDs		P23771	P25800
PDB IDs		4HC7 4HC9 4HCA
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Regulation Of Erythrocyte Differentiation Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Embryonic Organ Development Cardiovascular System Development Negative Regulation Of Cellular Metabolic Process Megakaryocyte Differentiation Nitrogen Compound Metabolic Process Erythrocyte Differentiation Erythrocyte Homeostasis Regulation Of Transcription, DNA-templated RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Hemopoiesis Regulation Of RNA Metabolic Process Embryonic Hemopoiesis Myeloid Cell Homeostasis Nucleobase-containing Compound Metabolic Process Cardiac Chamber Development Immune System Development Hematopoietic Progenitor Cell Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Myeloid Cell Differentiation Blood Vessel Morphogenesis Organ Development Immune System Process	Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Negative Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Cellular Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Wnt Signaling Pathway Organ Development Positive Regulation Of Cellular Metabolic Process Interferon-gamma Secretion Multicellular Organismal Development Cellular Metabolic Process Anatomical Structure Development Developmental Process System Development Interferon-gamma Production Negative Regulation Of Interleukin-2 Production Regulation Of Binding Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Cytokine Biosynthetic Process Definitive Hemopoiesis Embryo Development
Tagcloud ?		coactivated coexpressed cofactors collectively cryptic dehydrogenase endogeneous example exogenously forced hpb initiated intron lim lmo lymphoblastic mostly potentiated raldh2 regularly relate retinaldehyde subtractive synergistic synergy tal1 tried tumorigenesis	bhlh collaborates collaboration construct demonstrating dispensable dysregulation elements exerts helix inappropriately interfere interstitial juxtaposed lastly lymphoblastic mesoderm misexpressed oncogenesis product recapitulating scl sil situation supporting tcl5 transactivation translocations whereby
Tagcloud (Difference) ?		coactivated coexpressed cofactors collectively cryptic dehydrogenase endogeneous example exogenously forced hpb initiated intron lim lmo mostly potentiated raldh2 regularly relate retinaldehyde subtractive synergistic synergy tal1 tried tumorigenesis	bhlh collaborates collaboration construct demonstrating dispensable dysregulation elements exerts helix inappropriately interfere interstitial juxtaposed lastly mesoderm misexpressed oncogenesis product recapitulating scl sil situation supporting tcl5 transactivation translocations whereby
Tagcloud (Intersection) ?		lymphoblastic