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GATA3 and MED1
Number of citations of the paper that reports this interaction (PubMedID
11724781
)
0
Data Source:
HPRD
(in vitro)
GATA3
MED1
Description
GATA binding protein 3
mediator complex subunit 1
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Ubiquitin Ligase Complex
Chromatin
Nucleus
Nucleoplasm
Nucleolus
Membrane
Mediator Complex
Protein-DNA Complex
Core Mediator Complex
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
Transcription Coactivator Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Interleukin-2 Receptor Binding
Protein Binding
Zinc Ion Binding
Identical Protein Binding
Sequence-specific DNA Binding
Metal Ion Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
E-box Binding
HMG Box Domain Binding
Histone Methyltransferase Binding
Sequence-specific Double-stranded DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Transcription Coactivator Binding
DNA Binding
Chromatin Binding
Transcription Coregulator Activity
Transcription Coactivator Activity
Transcription Corepressor Activity
Protein Binding
Nuclear Receptor Binding
Nuclear Estrogen Receptor Binding
Chromatin DNA Binding
Histone Acetyltransferase Binding
Nuclear Vitamin D Receptor Binding
Nuclear Retinoic Acid Receptor Binding
Peroxisome Proliferator Activated Receptor Binding
Protein-containing Complex Binding
Nuclear Thyroid Hormone Receptor Binding
LBD Domain Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Ubiquitin Protein Ligase Activity
General Transcription Initiation Factor Binding
DNA-binding Transcription Factor Binding
Promoter-specific Chromatin Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Cell Morphogenesis
In Utero Embryonic Development
Cell Fate Determination
Neuron Migration
Cell Activation
Type IV Hypersensitivity
Regulation Of Cytokine Production
Positive Regulation Of Cytokine Production
Kidney Development
Mesonephros Development
Lens Development In Camera-type Eye
Immune System Process
Immune System Development
Pro-T Cell Differentiation
Aortic Valve Morphogenesis
Cardiac Right Ventricle Morphogenesis
Ventricular Septum Development
Chromatin Remodeling
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Defense Response
Inflammatory Response
Humoral Immune Response
Signal Transduction
Nervous System Development
Axon Guidance
Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Male Gonad Development
Response To Xenobiotic Stimulus
Response To Virus
Anatomical Structure Morphogenesis
Post-embryonic Development
Positive Regulation Of Signal Transduction
Response To Gamma Radiation
Gene Expression
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Epithelial To Mesenchymal Transition
Regulation Of Neuron Projection Development
Cell Differentiation
Neuron Differentiation
T Cell Differentiation
Erythrocyte Differentiation
Macrophage Differentiation
Regulation Of Epithelial Cell Differentiation
TOR Signaling
Negative Regulation Of Type II Interferon Production
Negative Regulation Of Interleukin-2 Production
Positive Regulation Of Interleukin-13 Production
Positive Regulation Of Interleukin-4 Production
Positive Regulation Of Interleukin-5 Production
T Cell Differentiation In Thymus
Negative Regulation Of Mammary Gland Epithelial Cell Proliferation
Embryonic Hemopoiesis
Cellular Response To Interferon-alpha
Ureter Maturation
Parathyroid Hormone Secretion
Norepinephrine Biosynthetic Process
Inner Ear Morphogenesis
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Neuron Apoptotic Process
Ear Development
Response To Estrogen
Thymic T Cell Selection
T-helper 2 Cell Differentiation
Innate Immune Response
Cell Fate Commitment
Response To Ethanol
Positive Regulation Of T Cell Differentiation
Positive Regulation Of Cell Differentiation
Regulation Of T-helper Cell Differentiation
Negative Regulation Of Cell Cycle
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Cell Maturation
Sympathetic Nervous System Development
Thymus Development
Embryonic Organ Development
Developmental Growth
Anatomical Structure Formation Involved In Morphogenesis
System Development
Homeostasis Of Number Of Cells
Negative Regulation Of Inflammatory Response
Regulation Of Developmental Process
T Cell Receptor Signaling Pathway
Cartilage Development
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Parathyroid Gland Development
Pharyngeal System Development
Uterus Development
Canonical Wnt Signaling Pathway
Mesenchymal To Epithelial Transition
Mast Cell Differentiation
Ureteric Bud Formation
Cellular Response To Cytokine Stimulus
Cellular Response To Interleukin-4
Cellular Response To Tumor Necrosis Factor
Otic Vesicle Development
Cellular Response To BMP Stimulus
Positive Regulation Of Ureteric Bud Formation
Nephric Duct Morphogenesis
Nephric Duct Formation
Regulation Of Nephron Tubule Epithelial Cell Differentiation
Ureter Morphogenesis
Lymphocyte Migration
Cochlea Development
Positive Regulation Of MiRNA Transcription
Regulation Of Establishment Of Cell Polarity
Negative Regulation Of Cell Motility
Negative Regulation Of Endothelial Cell Apoptotic Process
Positive Regulation Of T-helper 2 Cell Cytokine Production
Negative Regulation Of Cell Proliferation Involved In Mesonephros Development
Positive Regulation Of Thyroid Hormone Generation
Positive Regulation Of Transcription Regulatory Region DNA Binding
Regulation Of Cellular Response To X-ray
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Involved In Ureteric Bud Formation
Negative Regulation Of Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Involved In Ureteric Bud Formation
Negative Regulation Of Transcription By RNA Polymerase II
Cell Morphogenesis
Angiogenesis
In Utero Embryonic Development
Liver Development
Embryonic Placenta Development
Lens Development In Camera-type Eye
Thyroid Hormone Receptor Signaling Pathway
Ventricular Trabecula Myocardium Morphogenesis
Retinal Pigment Epithelium Development
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Thyroid Hormone Generation
Protein Import Into Nucleus
Androgen Biosynthetic Process
Brain Development
Heart Development
Lactation
Positive Regulation Of Cell Population Proliferation
Animal Organ Morphogenesis
Positive Regulation Of Gene Expression
Negative Regulation Of Keratinocyte Proliferation
Protein Ubiquitination
Keratinocyte Differentiation
Monocyte Differentiation
Nuclear Receptor-mediated Steroid Hormone Signaling Pathway
Animal Organ Regeneration
Positive Regulation Of Transcription Elongation By RNA Polymerase II
Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Mammary Gland Epithelial Cell Proliferation
Embryonic Heart Tube Development
Embryonic Hindlimb Morphogenesis
Embryonic Hemopoiesis
Peroxisome Proliferator Activated Receptor Signaling Pathway
Cellular Response To Hepatocyte Growth Factor Stimulus
Megakaryocyte Development
MRNA Transcription By RNA Polymerase II
Camera-type Eye Development
Negative Regulation Of Apoptotic Process
G0 To G1 Transition
Fat Cell Differentiation
Positive Regulation Of Keratinocyte Differentiation
Positive Regulation Of Erythrocyte Differentiation
Negative Regulation Of Neuron Differentiation
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Erythrocyte Development
Enucleate Erythrocyte Development
RNA Polymerase II Preinitiation Complex Assembly
Hematopoietic Stem Cell Differentiation
Positive Regulation Of Transcription Initiation By RNA Polymerase II
Positive Regulation Of Type II Interferon-mediated Signaling Pathway
Mammary Gland Branching Involved In Thelarche
Mammary Gland Branching Involved In Pregnancy
Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation
Positive Regulation Of G0 To G1 Transition
Regulation Of Vitamin D Receptor Signaling Pathway
Cellular Response To Epidermal Growth Factor Stimulus
Cellular Response To Steroid Hormone Stimulus
Cellular Response To Thyroid Hormone Stimulus
Positive Regulation Of Hepatocyte Proliferation
Regulation Of RNA Biosynthetic Process
Pathways
Ub-specific processing proteases
Interleukin-4 and Interleukin-13 signaling
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Formation of the nephric duct
Factors involved in megakaryocyte development and platelet production
Developmental Lineage of Mammary Stem Cells
BMAL1:CLOCK,NPAS2 activates circadian expression
PPARA activates gene expression
PPARA activates gene expression
Generic Transcription Pathway
Transcriptional activation of mitochondrial biogenesis
Activation of gene expression by SREBF (SREBP)
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathway
Regulation of lipid metabolism by PPARalpha
Estrogen-dependent gene expression
Cytoprotection by HMOX1
Heme signaling
RSV-host interactions
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Expression of BMAL (ARNTL), CLOCK, and NPAS2
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Drugs
Becocalcidiol
Diseases
GWAS
Acute lymphoblastic leukemia (adolescents and young adults) (
25468567
)
Acute lymphoblastic leukemia (B-cell precursor) (
29296818
23996088
)
Acute lymphoblastic leukemia in childhood (B cell precursor) (
29632299
)
Allergic disease (asthma, hay fever or eczema) (
29083406
29785011
)
Allergic rhinitis (
31361310
30013184
)
Allergy (
27182965
)
Asthma (
34103634
29273806
27182965
30929738
32296059
31361310
31619474
31959851
)
Asthma (adult onset) (
30929738
31036433
)
Asthma (childhood onset) (
30929738
31036433
)
Asthma (moderate or severe) (
30552067
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Autoimmune traits (pleiotropy) (
30572963
)
B cell acute lymphoblastic leukaemia (abnormal cytogenetics) (
29296818
)
B cell acute lymphoblastic leukaemia (hyperdiploid negative) (
29296818
)
B cell acute lymphoblastic leukaemia (normal cytogenetics) (
29296818
)
B cell acute lymphoblastic leukaemia (Philadelphia chromosome negative) (
29296818
)
B cell acute lymphoblastic leukaemia in adulthood (
29296818
)
B cell acute lymphoblastic leukaemia in young adulthood (
29296818
)
B-cell acute lymphoblastic leukaemia (
31767839
)
Basal cell carcinoma (
25855136
27539887
)
Benign prostatic hyperplasia and/or lower urinary tract symptoms (
28656603
)
Calcium levels (
24068962
)
Colorectal cancer (
30529582
28869801
25990418
24737748
31826910
)
Colorectal cancer (diet interaction) (
24743840
)
Colorectal cancer or advanced adenoma (
30510241
)
Craniofacial microsomia (
26853712
)
Eosinophil count (
27863252
32888494
)
Eosinophil percentage of white cells (
32888494
)
Fasting glucose change (short-term) (
31263163
)
General risk tolerance (MTAG) (
30643258
)
Glycemic traits (pleiotropy) (
31021400
)
Hair shape (
29220522
)
Hodgkin's lymphoma (
29196614
24920014
21037568
)
Intracranial aneurysm (
29531279
)
Lymphocyte count (
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Mild influenza (H1N1) infection (
26379185
)
Multiple sclerosis (
31604244
)
Nasal polyps (
30643255
)
Neutrophil percentage of white cells (
32888494
)
Nodular sclerosis Hodgkin lymphoma (
29196614
)
Obstetric antiphospholipid syndrome (
28424481
)
Paclitaxel disposition in epithelial ovarian cancer (
29367611
)
Plasma parathyroid hormone levels (
30134803
)
Recalcitrant atopic dermatitis (
25935106
)
Rheumatoid arthritis (
23143596
30572963
24390342
30423114
)
Rheumatoid arthritis (ACPA-positive) (
24532676
23143596
)
Scalp hair shape (
26926045
)
Selective IgA deficiency (
27723758
)
Self-reported allergy (
23817569
)
Smoking status (ever vs never smokers) (
30643258
)
Stroke (
26089329
)
Systemic lupus erythematosus (
26502338
)
Takayasu arteritis (
25604533
)
Thyroid stimulating hormone levels (
30367059
)
Type 1 diabetes (
31152121
34012112
)
Asthma (
31619474
)
Creatinine levels (
29403010
)
Estimated glomerular filtration rate (
30604766
)
Glomerular filtration rate (
29403010
)
Lung function (FVC) (
30061609
)
Refractive error (
32231278
)
Rheumatoid arthritis (
24390342
30423114
)
Spherical equivalent or myopia (age of diagnosis) (
29808027
)
Systemic lupus erythematosus (
24871463
)
Ulcerative colitis (
20228799
)
Interacting Genes
33 interacting genes:
ACTN2
CDK2
CYSRT1
ETS1
ETS2
FBXW7
HDAC2
HDAC3
HIF1A
KDM1A
KRTAP12-1
KRTAP13-2
KRTAP6-2
KRTAP6-3
LCK
LMO1
LMO2
MAPK14
MED1
NFIA
NFIB
NFIC
PLEKHG4
PSMA3
RARB
REPIN1
SATB1
SP1
SPI1
TAL1
TRIM55
TRIM63
ZFPM2
50 interacting genes:
AKAP9
AR
BRCA1
CASK
CEBPA
CHEK1
CHEK2
CTDP1
ESR1
ESR2
EZH2
GABPA
GATA1
GATA3
GATA4
GATA6
GJB5
HNF4A
KIF1A
MAPK3
MDM2
MED12
MED14
MED25
MED8
MED9
MYC
NCOA6
NR1H2
NR1I3
NR3C1
NR4A1
PIN1
PPARA
PPARG
PPARGC1A
RARA
RBM5
RORA
RXRA
SREBF1
TET2
TFIP11
THRA
THRB
TP53
UBC
VDR
YWHAH
YWHAQ
Entrez ID
2625
5469
HPRD ID
00572
05055
Ensembl ID
ENSG00000107485
ENSG00000125686
Uniprot IDs
P23771
Q15648
PDB IDs
4HC7
4HC9
4HCA
1RJK
1RK3
1RKG
1RKH
2O4J
2O4R
2ZFX
3A2H
3AUN
3VJS
3VJT
3VRT
3VRU
3VRV
3VRW
3W0G
3W0H
3W0I
3W0J
3W5P
3W5Q
3W5R
3W5T
3WT5
3WT6
3WT7
3WTQ
4YNK
5AWJ
5AWK
5B41
5B5B
5GIC
5GID
5GIE
5XPM
5XPN
5XPO
5XPP
5XUQ
5XZF
5XZH
5ZWE
5ZWF
5ZWH
5ZWI
6D94
6JEZ
6K5O
6ONJ
7C7V
7C7W
7EMF
7ENA
7ENC
7ENJ
7OXU
7VQP
8GXQ
8GXS
8T9D
8TQW
8TRH
Enriched GO Terms of Interacting Partners
?
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Erythrocyte Differentiation
Chromatin
DNA-binding Transcription Factor Binding
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Metabolic Process
Nucleoplasm
Negative Regulation Of DNA-templated Transcription
Regulation Of RNA Metabolic Process
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of Gene Expression
DNA-binding Transcription Factor Activity
Regulation Of Macromolecule Biosynthetic Process
Histone Deacetylase Binding
Regulation Of Myeloid Cell Differentiation
Negative Regulation Of Macromolecule Biosynthetic Process
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Neural Precursor Cell Proliferation
Negative Regulation Of Metabolic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Protein De-2-hydroxyisobutyrylase Activity
Positive Regulation Of Myeloid Cell Differentiation
Regulation Of Cell Population Proliferation
Regulation Of Hemopoiesis
Regulation Of Macromolecule Metabolic Process
Generation Of Neurons
Positive Regulation Of Chromatin Organization
Protein Lysine Delactylase Activity
Sequence-specific DNA Binding
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Embryonic Hemopoiesis
Protein Binding
Regulation Of Metabolic Process
Nucleus
Nuclear Receptor Activity
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Metabolic Process
Sequence-specific DNA Binding
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of Biosynthetic Process
DNA-binding Transcription Factor Activity
Nucleoplasm
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Regulation Of Primary Metabolic Process
Intracellular Receptor Signaling Pathway
Positive Regulation Of Macromolecule Metabolic Process
Chromatin
Positive Regulation Of Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Gene Expression
Negative Regulation Of DNA-templated Transcription
Transcription Coactivator Binding
Nuclear Receptor-mediated Signaling Pathway
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of RNA Metabolic Process
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-templated Transcription
Regulation Of MiRNA Transcription
Hormone-mediated Signaling Pathway
DNA Binding
Transcription Cis-regulatory Region Binding
Intracellular Signal Transduction
Regulation Of MiRNA Metabolic Process
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Transcription By RNA Polymerase II
Nucleus
Cell Differentiation
Nucleobase-containing Compound Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Negative Regulation Of Biosynthetic Process
Macromolecule Biosynthetic Process
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