GATA3 and TRIM55

Number of citations of the paper that reports this interaction (PubMedID 31391242)
0

Data Source:
BioGRID (two hybrid)

		GATA3	TRIM55
Description		GATA binding protein 3	tripartite motif containing 55
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Nucleus Cytoplasm Microtubule
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding Transcription Coactivator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Interleukin-2 Receptor Binding Protein Binding Zinc Ion Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding HMG Box Domain Binding Histone Methyltransferase Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Zinc Ion Binding Transferase Activity Protein-macromolecule Adaptor Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis In Utero Embryonic Development Cell Fate Determination Neuron Migration Cell Activation Type IV Hypersensitivity Regulation Of Cytokine Production Positive Regulation Of Cytokine Production Kidney Development Mesonephros Development Lens Development In Camera-type Eye Immune System Process Immune System Development Pro-T Cell Differentiation Aortic Valve Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Septum Development Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Defense Response Inflammatory Response Humoral Immune Response Signal Transduction Nervous System Development Axon Guidance Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Male Gonad Development Response To Xenobiotic Stimulus Response To Virus Anatomical Structure Morphogenesis Post-embryonic Development Positive Regulation Of Signal Transduction Response To Gamma Radiation Gene Expression Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Neuron Projection Development Cell Differentiation Neuron Differentiation T Cell Differentiation Erythrocyte Differentiation Macrophage Differentiation Regulation Of Epithelial Cell Differentiation TOR Signaling Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-5 Production T Cell Differentiation In Thymus Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Embryonic Hemopoiesis Cellular Response To Interferon-alpha Ureter Maturation Parathyroid Hormone Secretion Norepinephrine Biosynthetic Process Inner Ear Morphogenesis Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Neuron Apoptotic Process Ear Development Response To Estrogen Thymic T Cell Selection T-helper 2 Cell Differentiation Innate Immune Response Cell Fate Commitment Response To Ethanol Positive Regulation Of T Cell Differentiation Positive Regulation Of Cell Differentiation Regulation Of T-helper Cell Differentiation Negative Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Sympathetic Nervous System Development Thymus Development Embryonic Organ Development Developmental Growth Anatomical Structure Formation Involved In Morphogenesis System Development Homeostasis Of Number Of Cells Negative Regulation Of Inflammatory Response Regulation Of Developmental Process T Cell Receptor Signaling Pathway Cartilage Development Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Parathyroid Gland Development Pharyngeal System Development Uterus Development Canonical Wnt Signaling Pathway Mesenchymal To Epithelial Transition Mast Cell Differentiation Ureteric Bud Formation Cellular Response To Cytokine Stimulus Cellular Response To Interleukin-4 Cellular Response To Tumor Necrosis Factor Otic Vesicle Development Cellular Response To BMP Stimulus Positive Regulation Of Ureteric Bud Formation Nephric Duct Morphogenesis Nephric Duct Formation Regulation Of Nephron Tubule Epithelial Cell Differentiation Ureter Morphogenesis Lymphocyte Migration Cochlea Development Positive Regulation Of MiRNA Transcription Regulation Of Establishment Of Cell Polarity Negative Regulation Of Cell Motility Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of T-helper 2 Cell Cytokine Production Negative Regulation Of Cell Proliferation Involved In Mesonephros Development Positive Regulation Of Thyroid Hormone Generation Positive Regulation Of Transcription Regulatory Region DNA Binding Regulation Of Cellular Response To X-ray Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Involved In Ureteric Bud Formation Negative Regulation Of Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Involved In Ureteric Bud Formation	Leukocyte Migration Involved In Inflammatory Response Signal Transduction Canonical NF-kappaB Signal Transduction Innate Immune Response Diapedesis Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Macrophage Migration
Pathways		Ub-specific processing proteases Interleukin-4 and Interleukin-13 signaling RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Formation of the nephric duct Factors involved in megakaryocyte development and platelet production Developmental Lineage of Mammary Stem Cells
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (adolescents and young adults) ( 25468567) Acute lymphoblastic leukemia (B-cell precursor) ( 29296818 23996088) Acute lymphoblastic leukemia in childhood (B cell precursor) ( 29632299) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 31361310 30013184) Allergy ( 27182965) Asthma ( 34103634 29273806 27182965 30929738 32296059 31361310 31619474 31959851) Asthma (adult onset) ( 30929738 31036433) Asthma (childhood onset) ( 30929738 31036433) Asthma (moderate or severe) ( 30552067) Asthma or allergic disease (pleiotropy) ( 29785011) Autoimmune traits (pleiotropy) ( 30572963) B cell acute lymphoblastic leukaemia (abnormal cytogenetics) ( 29296818) B cell acute lymphoblastic leukaemia (hyperdiploid negative) ( 29296818) B cell acute lymphoblastic leukaemia (normal cytogenetics) ( 29296818) B cell acute lymphoblastic leukaemia (Philadelphia chromosome negative) ( 29296818) B cell acute lymphoblastic leukaemia in adulthood ( 29296818) B cell acute lymphoblastic leukaemia in young adulthood ( 29296818) B-cell acute lymphoblastic leukaemia ( 31767839) Basal cell carcinoma ( 25855136 27539887) Benign prostatic hyperplasia and/or lower urinary tract symptoms ( 28656603) Calcium levels ( 24068962) Colorectal cancer ( 30529582 28869801 25990418 24737748 31826910) Colorectal cancer (diet interaction) ( 24743840) Colorectal cancer or advanced adenoma ( 30510241) Craniofacial microsomia ( 26853712) Eosinophil count ( 27863252 32888494) Eosinophil percentage of white cells ( 32888494) Fasting glucose change (short-term) ( 31263163) General risk tolerance (MTAG) ( 30643258) Glycemic traits (pleiotropy) ( 31021400) Hair shape ( 29220522) Hodgkin's lymphoma ( 29196614 24920014 21037568) Intracranial aneurysm ( 29531279) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mild influenza (H1N1) infection ( 26379185) Multiple sclerosis ( 31604244) Nasal polyps ( 30643255) Neutrophil percentage of white cells ( 32888494) Nodular sclerosis Hodgkin lymphoma ( 29196614) Obstetric antiphospholipid syndrome ( 28424481) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Plasma parathyroid hormone levels ( 30134803) Recalcitrant atopic dermatitis ( 25935106) Rheumatoid arthritis ( 23143596 30572963 24390342 30423114) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Scalp hair shape ( 26926045) Selective IgA deficiency ( 27723758) Self-reported allergy ( 23817569) Smoking status (ever vs never smokers) ( 30643258) Stroke ( 26089329) Systemic lupus erythematosus ( 26502338) Takayasu arteritis ( 25604533) Thyroid stimulating hormone levels ( 30367059) Type 1 diabetes ( 31152121 34012112)	Coronary heart disease event reduction (statin therapy interaction) ( 22666496) Metabolite levels ( 23823483) Recurrent major depressive disorder ( 29317602)
Interacting Genes		33 interacting genes: ACTN2 CDK2 CYSRT1 ETS1 ETS2 FBXW7 HDAC2 HDAC3 HIF1A KDM1A KRTAP12-1 KRTAP13-2 KRTAP6-2 KRTAP6-3 LCK LMO1 LMO2 MAPK14 MED1 NFIA NFIB NFIC PLEKHG4 PSMA3 RARB REPIN1 SATB1 SP1 SPI1 TAL1 TRIM55 TRIM63 ZFPM2	306 interacting genes: ACBD4 ACD ACTA1 ADAMTSL4 AEBP2 AFM AGO2 AKR1C8 ALKBH3 ANKRD1 ANKRD39 APLN APOBEC4 ARL6IP4 ATG4D ATP5F1B ATP5F1D ATXN3 ATXN3L ATXN7L1 BCAT1 BCHE BRAP BRD4 BRWD1 BTBD9 BYSL C10orf88 C1orf35 C3orf36 C8orf74 CADPS CAMK2A CAPN3 CARS1 CBX2 CCDC120 CCDC28B CDK3 CDS2 CENPK CHMP7 CKM COA7 COX4I1 CRCT1 CTAG1A CTAG1B CTNNB1 CTSF CYB5R2 CYP46A1 CYTOR DAPL1 DCAF11 DCAF6 DCTN3 DECR2 DEF8 DEK DES DNTTIP1 DOCK7 DYNLT2B EED EEF1G EHHADH EIF3E ELAPOR1 EPS8L2 ESPL1 EZH2 FAM185A FAM90A1 FANK1 FASTKD1 FERRY3 FHL2 FKBP6 FLNA FLNB FLNC FRMD6 FYN GABPB1 GATA3 GFM1 GLI4 GMEB1 GOLGA2P5 GPRIN2 GPS1 GRB10 GRB14 HID1 HIRA HOXA1 HROB ID1 IFI35 IGF2 IK IL37 ILF3 INCA1 ING4 INKA1 IQUB IRF2 IRF3 ITGB5 JADE3 KBTBD4 KCTD15 KIAA0087 KIAA0408 KIF13A KIF1B KIF5A KLHDC4 KLHL36 KMT2B KYAT1 LAGE3 LAMTOR5 LAPTM4A LIMS2 LINC00518 LINC00663 LINC00905 LINC01588 LMCD1 LMO2 LRRC56 LYN LYNX1 MAGEC3 MALSU1 MAP3K14 MBD4 MBIP MDM4 MIDN MIIP MKI67 MLH3 MLLT11 MPP1 MPZL1 MRPL19 MRPL20-AS1 MRPL41 MSRB3 MYBPC1 MYBPC3 MYBPHL MYCT1 MYOT MYOZ1 NDUFA1 NDUFA8 NEB NEBL NEFL NGEF NOMO1 NR1D2 NR2C2 NSD3 NSUN7 NUFIP2 ODF2 OGFOD2 OTUB1 OTUB2 P3H3 PACRGL PAFAH1B2 PCGF1 PCGF3 PCGF6 PELI3 PELO PHC2 PHF23 PIAS1 PIAS2 PIAS3 PIP4K2B PLEKHG4 PLXNA3 POLD1 POLR2E PPARA PPIE PRKAB2 PRKACA PRR30 PRRT1 PYGM RABEPK RAD23A RAI2 RBM14 RELA REX1BD RGR RHEB RHPN1 RING1 RNF10 RNF114 RPS4X RRAS RUSC1 RUSC1-AS1 SEC23B SET SHFL SLC6A13 SLFN12 SNW1 SPATS1 SPRYD7 SPSB1 SPSB2 SQSTM1 STAM SYMPK SYNCRIP TCAP TCP10L TEX19 THAP3 TIGD5 TIMM17B TMBIM1 TMEM35A TNIP3 TNNI1 TNNI2 TNNI3 TOR1AIP2 TPD52L3 TRAF3IP2 TRIB3 TRIM23 TRIM27 TRIM35 TRIM41 TRIM54 TRIM63 TRIM69 TRMT10B TSC2 TSC22D4 TTN TUBGCP4 UBA3 UBE2D1 UBE2D2 UBE2D3 UBE2E3 UBE2L3 UCHL3 UCHL5 UNKL USP13 USP28 USP4 USP5 USP7 USP8 UXT VAC14 VPS37A WT1 XAGE1B YJU2B YOD1 YPEL3 ZBTB14 ZBTB17 ZC2HC1C ZC3H12A ZC3HC1 ZFYVE19 ZNF124 ZNF20 ZNF302 ZNF333 ZNF345 ZNF431 ZNF436 ZNF460 ZNF566 ZNF57 ZNF581 ZNF597 ZNF649 ZNF653 ZNF667-AS1 ZNF767P ZNF775 ZNF83 ZSCAN16
Entrez ID		2625	84675
HPRD ID		00572	05927
Ensembl ID		ENSG00000107485	ENSG00000147573
Uniprot IDs		P23771	Q9BYV6
PDB IDs		4HC7 4HC9 4HCA
Enriched GO Terms of Interacting Partners?		RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Erythrocyte Differentiation Chromatin DNA-binding Transcription Factor Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Nucleoplasm Negative Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Gene Expression DNA-binding Transcription Factor Activity Regulation Of Macromolecule Biosynthetic Process Histone Deacetylase Binding Regulation Of Myeloid Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Neural Precursor Cell Proliferation Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Protein De-2-hydroxyisobutyrylase Activity Positive Regulation Of Myeloid Cell Differentiation Regulation Of Cell Population Proliferation Regulation Of Hemopoiesis Regulation Of Macromolecule Metabolic Process Generation Of Neurons Positive Regulation Of Chromatin Organization Protein Lysine Delactylase Activity Sequence-specific DNA Binding Positive Regulation Of Blood Vessel Endothelial Cell Migration Embryonic Hemopoiesis Protein Binding Regulation Of Metabolic Process Nucleus	Protein Binding Post-translational Protein Modification Cysteine-type Peptidase Activity Cysteine-type Deubiquitinase Activity Nucleus Protein Modification By Small Protein Conjugation Protein Deubiquitination Protein Modification By Small Protein Removal Z Disc Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Titin Binding Protein Ubiquitination Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Zinc Ion Binding Negative Regulation Of Metabolic Process Protein Modification Process Negative Regulation Of Transcription By RNA Polymerase II PRC1 Complex Sarcomere Organization Nucleoplasm Regulation Of RNA Metabolic Process Structural Constituent Of Muscle Contractile Muscle Fiber TORC1 Signaling TOR Signaling Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Transcription By RNA Polymerase II Protein K48-linked Deubiquitination PcG Protein Complex Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of TORC1 Signaling K48-linked Deubiquitinase Activity Regulation Of Primary Metabolic Process Negative Regulation Of Protein Sumoylation Negative Regulation Of TORC1 Signaling Transcription Corepressor Activity Negative Regulation Of Translation Protein Metabolic Process Regulation Of Protein Sumoylation Negative Regulation Of Catabolic Process Sarcomere
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