TNFRSF18 and TRAF3

Number of citations of the paper that reports this interaction (PMID 10037686)
31

Data Source:
HPRD (in vivo, in vitro)

		TNFRSF18	TRAF3
Gene Name		tumor necrosis factor receptor superfamily, member 18	TNF receptor-associated factor 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Integral Component Of Plasma Membrane External Side Of Plasma Membrane	Mitochondrion Endosome Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex
	Molecular Function	Tumor Necrosis Factor-activated Receptor Activity	Ubiquitin-protein Transferase Activity Signal Transducer Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ligase Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Thioesterase Binding
	Biological Process	Apoptotic Process Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Apoptotic Process	Regulation Of Cytokine Production Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Apoptotic Process Signal Transduction Toll Signaling Pathway Protein Ubiquitination Regulation Of Proteolysis Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Type I Interferon Production Regulation Of Interferon-beta Production Tumor Necrosis Factor-mediated Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Apoptotic Process Innate Immune Response Regulation Of Defense Response To Virus
Pathways			Activated TLR4 signalling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways TRAF3-dependent IRF activation pathway Toll-Like Receptors Cascades Negative regulators of RIG-I/MDA5 signaling TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade MyD88-independent cascade Innate Immune System Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)	Brain imaging in schizophrenia (interaction) ( 19023125)
Protein-Protein Interactions		5 interactors: LNX1 TNFSF18 TRAF1 TRAF2 TRAF3	55 interactors: ABCC1 ALPL APOBEC3C AZI2 BIRC3 CASP3 CD27 CD40 DAXX EDA2R EDAR EWSR1 FAS GRIN1 GRIN2D IL15 IRF1 LTBR MAP2K1 MAP3K14 NGFRAP1 NUP62 OTUD5 PDLIM7 RIPK1 RRAS2 SAR1A SRC TANK TBK1 TDP2 TICAM1 TNFRSF11A TNFRSF12A TNFRSF13C TNFRSF14 TNFRSF17 TNFRSF18 TNFRSF19 TNFRSF1A TNFRSF1B TNFRSF4 TNFRSF8 TNFRSF9 TRADD TRAF2 TRAF3IP1 TRAF3IP2 TRAF3IP3 TRAF5 TRIM37 UBE2I USP7 ZBP1 ZMYND11
Entrez ID		8784	7187
HPRD ID		04879	03539
Ensembl ID		ENSG00000186891	ENSG00000131323
Uniprot IDs		Q9Y5U5	A6NHG8 Q13114
PDB IDs			1FLK 1FLL 1KZZ 1L0A 1RF3 1ZMS 2ECY 2GKW
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Tumor Necrosis Factor Response To Tumor Necrosis Factor Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cytokine-mediated Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Apoptotic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Cell Death Toll-like Receptor 4 Signaling Pathway Protein Ubiquitination Cellular Response To Cytokine Stimulus Protein Modification By Small Protein Conjugation Toll-like Receptor Signaling Pathway Response To Cytokine Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Apoptotic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Programmed Cell Death Protein Complex Assembly Cell Death Death Regulation Of Innate Immune Response Protein Homooligomerization Negative Regulation Of Glial Cell Apoptotic Process Immune Response Regulation Of T Cell Activation Regulation Of Immune System Process Positive Regulation Of Protein Homodimerization Activity T Cell Proliferation Involved In Immune Response Toll Signaling Pathway Cellular Response To Nitric Oxide Regulation Of Cell-cell Adhesion Regulation Of Immunoglobulin Secretion Regulation Of Lymphocyte Activation Response To Nitric Oxide Protein Oligomerization Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Positive Regulation Of T Cell Cytokine Production Protein Homotrimerization Regulation Of Protein Homodimerization Activity Cellular Response To Organic Substance Cellular Response To Reactive Nitrogen Species	Cell Death Death Tumor Necrosis Factor-mediated Signaling Pathway Programmed Cell Death Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Apoptotic Process Response To Tumor Necrosis Factor Cellular Response To Tumor Necrosis Factor Regulation Of Cytokine Production Signal Transduction Positive Regulation Of Protein Metabolic Process Immune System Process Regulation Of Protein Metabolic Process Cellular Response To Stimulus Extrinsic Apoptotic Signaling Pathway Signaling Regulation Of Signal Transduction Cell Communication Regulation Of Signaling Response To Stimulus Immune Response Regulation Of Cell Death Positive Regulation Of Cellular Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cytokine Production Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Process Regulation Of Apoptotic Process Response To Cytokine Regulation Of Immune System Process Regulation Of Phosphorylation Regulation Of Lymphocyte Activation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Apoptotic Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Phosphorus Metabolic Process Cellular Response To Organic Substance Response To Organic Substance Cellular Response To Cytokine Stimulus Regulation Of Cell Activation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cell Death
Tagcloud ?		br ccl20 ccl3 ccl4 csf2 csf3 cxcl1 cxcl12 discordances extremities figf grew icam3 igfbp1 iib il1alpha il1beta il6 il8 lymphatic matrigel mmp1 mmp13 mmp9 mts6 plaur plgf vegfa vegfc	adhesion affinity bind cd40 cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular jak3 kappab mediators molecule much mutants necrosis residues strongly tail traf2 traf5 traf6 transduction
Tagcloud (Difference) ?		br ccl20 ccl3 ccl4 csf2 csf3 cxcl1 cxcl12 discordances extremities figf grew icam3 igfbp1 iib il1alpha il1beta il6 il8 lymphatic matrigel mmp1 mmp13 mmp9 mts6 plaur plgf vegfa vegfc	adhesion affinity bind cd40 cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular jak3 kappab mediators molecule much mutants necrosis residues strongly tail traf2 traf5 traf6 transduction
Tagcloud (Intersection) ?