GBF1 and ZYG11B

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		GBF1	ZYG11B
Name		golgi brefeldin A resistant guanine nucleotide exchange factor 1	zyg-11 family member B, cell cycle regulator
Structure		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Peroxisome Endoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Golgi Stack Cis-Golgi Network Trans-Golgi Network Lipid Droplet Cytosol Membrane Cell Leading Edge Golgi Apparatus Subcompartment	Cytoplasm Cul2-RING Ubiquitin Ligase Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Lipid Binding Phosphatidylinositol-3,5-bisphosphate Binding	Protein Binding
	Biological Process	Cell Activation Involved In Immune Response Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Post-Golgi Vesicle-mediated Transport Golgi To Endosome Transport Golgi Organization Regulation Of Mitotic Cell Cycle Endomembrane System Organization Protein Transport Endosomal Transport Neutrophil Chemotaxis Regulation Of ARF Protein Signal Transduction Protein Localization To Golgi Apparatus Retrograde Transport, Endosome To Golgi COPI Coating Of Golgi Vesicle Cilium Assembly Establishment Of Monopolar Cell Polarity Protein Localization To Endoplasmic Reticulum Exit Site Golgi Disassembly Endoplasmic Reticulum-Golgi Intermediate Compartment Organization Cellular Response To Virus Reactive Oxygen Species Biosynthetic Process Protein Localization To Endoplasmic Reticulum Tubular Network Regulation Of Protein Localization To Cell Surface	Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Pathways		trans-Golgi Network Vesicle Budding VxPx cargo-targeting to cilium COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic	None
GWAS		Adult body size ( 32376654 ) General cognitive ability ( 29844566 ) Hand grip strength ( 29313844 ) Household income (MTAG) ( 31844048 ) Intelligence (MTAG) ( 29326435 ) Lymphocyte count ( 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892 ) QT interval ( 24952745 ) Refractive error ( 32231278 ) Smoking initiation (ever regular vs never regular) ( 30679032 ) Triglyceride levels ( 32154731 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )	Monocyte percentage of white cells ( 32888494 )
Novel Interactors		None recorded	10 novel interactors: ARPC2 ASPA BTBD2 BTF3L4 CFL2 NDC1 OSBPL9 SH2D2A TLR6 UCK2
Interacting Genes		9 interacting genes: CDK1 PNPLA2 SRPK2 UBC USO1 WEE2-AS1 YAP1 YWHAG ZYG11B	4 interacting genes: CUL2 ELOB ELOC GBF1
Entrez ID		8729	79699
HPRD ID		04740	13356
Ensembl ID		ENSG00000107862	ENSG00000162378
Uniprot IDs		A0A669KB10 A0A669KBG8 A0A7I2V2L5 A0A7I2V452 A0A7I2V514 A0A7I2YQ65 Q92538	A8DPD7 B4DK95 Q9C0D3
PDB IDs		Not available	7EP0 7EP1 7EP2 7XV7 7XYV 7XYW 7XYX 7YC2
GO Terms Enriched among Interactors		Organelle Fusion Positive Regulation Of Heart Growth Positive Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Cardiac Muscle Cell Proliferation Pronuclear Fusion Positive Regulation Of Organ Growth Regulation Of Heart Growth Golgi Vesicle Docking Enterocyte Differentiation Organelle Disassembly Nucleus Organization Intracellular Signal Transduction Mitotic DNA-templated DNA Replication Mitotic DNA Replication DNA Synthesis Involved In Mitotic DNA Replication Cyclin B1-CDK1 Complex Regulation Of Organ Growth Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Positive Regulation Of Protein Localization To Nucleus Cyclin-dependent Protein Kinase Activity Protein Kinase C Inhibitor Activity TEAD-YAP Complex Negative Regulation Of Triglyceride Storage Mono-olein Transacylation Activity Diolein Transacylation Activity Acylglycerol Acyl-chain Remodeling Golgi Organization Regulation Of Schwann Cell Differentiation Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Nuclear Speck Organization Lateral Mesoderm Development Cardiac Muscle Tissue Regeneration Acylglycerol O-acyltransferase Activity Pre-mRNA 5'-splice Site Binding	Cul2-RING Ubiquitin Ligase Complex Target-directed MiRNA Degradation Elongin Complex Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Negative Regulation Of MiRNA-mediated Gene Silencing MiRNA Catabolic Process Cul5-RING Ubiquitin Ligase Complex MiRNA Metabolic Process Regulation Of Post-transcriptional Gene Silencing Regulation Of MiRNA-mediated Gene Silencing Aspartoacylase Activity Protein-macromolecule Adaptor Activity Transcription Corepressor Binding Transcription Initiation At RNA Polymerase II Promoter Protein Localization To Endoplasmic Reticulum Tubular Network Diacyl Lipopeptide Binding Nuclear Pore Transmembrane Ring Actin Polymerization Or Depolymerization Cell Leading Edge Actin Cytoskeleton Golgi Apparatus Subcompartment Endoplasmic Reticulum-Golgi Intermediate Compartment Organization Toll-like Receptor 2-Toll-like Receptor 6 Protein Complex Detection Of Diacyl Bacterial Lipopeptide DNA-templated Transcription Initiation Acetate Metabolic Process Cytosol VCB Complex CTP Salvage Muscle Cell Projection Membrane Actin Filament Fragmentation Cytidine Kinase Activity Uridine Kinase Activity CMP Biosynthetic Process Endomembrane System Organization Toll-like Receptor 2 Binding Detection Of Bacterial Lipoprotein Toll-like Receptor TLR6:TLR2 Signaling Pathway