GBF1

Name	golgi brefeldin A resistant guanine nucleotide exchange factor 1
Structure	No pdb structure
Interactors	9 interactors: CDK1 PNPLA2 SRPK2 UBC USO1 WEE2-AS1 YAP1 YWHAG ZYG11B
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Peroxisome Endoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Golgi Stack Cis-Golgi Network Trans-Golgi Network Lipid Droplet Cytosol Membrane Cell Leading Edge Golgi Apparatus Subcompartment
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Lipid Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Cell Activation Involved In Immune Response Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Post-Golgi Vesicle-mediated Transport Golgi To Endosome Transport Golgi Organization Regulation Of Mitotic Cell Cycle Endomembrane System Organization Protein Transport Endosomal Transport Neutrophil Chemotaxis Regulation Of ARF Protein Signal Transduction Protein Localization To Golgi Apparatus Retrograde Transport, Endosome To Golgi COPI Coating Of Golgi Vesicle Cilium Assembly Establishment Of Monopolar Cell Polarity Protein Localization To Endoplasmic Reticulum Exit Site Golgi Disassembly Endoplasmic Reticulum-Golgi Intermediate Compartment Organization Cellular Response To Virus Reactive Oxygen Species Biosynthetic Process Protein Localization To Endoplasmic Reticulum Tubular Network Regulation Of Protein Localization To Cell Surface
Pathways	trans-Golgi Network Vesicle Budding VxPx cargo-targeting to cilium COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
GWAS	Adult body size ( 32376654 ) General cognitive ability ( 29844566 ) Hand grip strength ( 29313844 ) Household income (MTAG) ( 31844048 ) Intelligence (MTAG) ( 29326435 ) Lymphocyte count ( 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892 ) QT interval ( 24952745 ) Refractive error ( 32231278 ) Smoking initiation (ever regular vs never regular) ( 30679032 ) Triglyceride levels ( 32154731 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )
Entrez ID	8729
HPRD ID	04740
Ensembl ID	ENSG00000107862
Uniprot IDs	A0A669KB10 A0A669KBG8 A0A7I2V2L5 A0A7I2V452 A0A7I2V514 A0A7I2YQ65 Q92538
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Organelle Fusion Positive Regulation Of Heart Growth Positive Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Cardiac Muscle Cell Proliferation Pronuclear Fusion Positive Regulation Of Organ Growth Regulation Of Heart Growth Golgi Vesicle Docking Enterocyte Differentiation Organelle Disassembly Nucleus Organization Intracellular Signal Transduction Mitotic DNA-templated DNA Replication Mitotic DNA Replication DNA Synthesis Involved In Mitotic DNA Replication Cyclin B1-CDK1 Complex Regulation Of Organ Growth Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Positive Regulation Of Protein Localization To Nucleus Cyclin-dependent Protein Kinase Activity Protein Kinase C Inhibitor Activity TEAD-YAP Complex Negative Regulation Of Triglyceride Storage Mono-olein Transacylation Activity Diolein Transacylation Activity Acylglycerol Acyl-chain Remodeling Golgi Organization Regulation Of Schwann Cell Differentiation Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Nuclear Speck Organization Lateral Mesoderm Development Cardiac Muscle Tissue Regeneration Acylglycerol O-acyltransferase Activity Pre-mRNA 5'-splice Site Binding