GBF1 and PNPLA2

Number of citations of the paper that reports this interaction (PMID 21789191)
8

Data Source:
BioGRID (pull down, pull down, imaging technique)

		GBF1	PNPLA2
Gene Name		golgi brefeldin A resistant guanine nucleotide exchange factor 1	patatin-like phospholipase domain containing 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Mitochondrion Peroxisome Endoplasmic Reticulum Lumen Golgi Apparatus Golgi Stack Cis-Golgi Network Trans-Golgi Network Membrane	Endoplasmic Reticulum Membrane Lipid Particle Cytosol Plasma Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	ARF Guanyl-nucleotide Exchange Factor Activity Protein Binding	Triglyceride Lipase Activity
	Biological Process	Retrograde Vesicle-mediated Transport, Golgi To ER Post-Golgi Vesicle-mediated Transport Organelle Organization Viral Process Vesicle-mediated Transport Regulation Of ARF Protein Signal Transduction Positive Regulation Of GTPase Activity COPI Coating Of Golgi Vesicle Membrane Organization	Phospholipid Metabolic Process Negative Regulation Of Sequestering Of Triglyceride Positive Regulation Of Triglyceride Catabolic Process Triglyceride Catabolic Process Lipid Storage Lipid Particle Organization Acylglycerol Acyl-chain Remodeling Small Molecule Metabolic Process Glycerophospholipid Biosynthetic Process
Pathways		Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance VxPx cargo-targeting to cilium COPI Mediated Transport Assembly of the primary cilium trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding Golgi to ER Retrograde Transport	Metabolism of lipids and lipoproteins Acyl chain remodeling of DAG and TAG Phospholipid metabolism Glycerophospholipid biosynthesis
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: PNPLA2 USO1 YWHAG	10 interactors: ABHD5 ARFGEF2 CYTH2 FAF2 GBF1 MARK3 PHYHIP SERPINF1 SMAD9 UBE2R2
Entrez ID		8729	57104
HPRD ID		04740	11443
Ensembl ID		ENSG00000107862	ENSG00000177666
Uniprot IDs		Q149P0 Q149P1 Q92538	Q96AD5
PDB IDs
Enriched GO Terms of Interacting Partners?		Golgi Vesicle Docking Acylglycerol Acyl-chain Remodeling Negative Regulation Of Sequestering Of Triglyceride Vesicle Fusion With Golgi Apparatus Positive Regulation Of Triglyceride Catabolic Process Transcytosis Lipid Particle Organization Negative Regulation Of Lipid Storage Organelle Organization Triglyceride Catabolic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Mitotic Cell Cycle Acylglycerol Catabolic Process Positive Regulation Of Lipid Catabolic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Membrane Organization Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Triglyceride Metabolic Process Intracellular Protein Transport Lipid Storage Vesicle Fusion Regulation Of Lipid Catabolic Process Regulation Of Lipid Storage Positive Regulation Of Mitochondrion Organization Cell Cycle Cellular Protein Localization Organelle Fusion Protein Transport Vesicle Docking Establishment Of Protein Localization Membrane Docking Regulation Of Mitochondrion Organization Intracellular Transport Triglyceride Metabolic Process ER To Golgi Vesicle-mediated Transport	Regulation Of ARF Protein Signal Transduction Regulation Of Catalytic Activity Positive Regulation Of Hydrolase Activity Post-Golgi Vesicle-mediated Transport Cellular Response To Cobalt Ion Regulation Of Ras Protein Signal Transduction Positive Regulation Of Catalytic Activity Negative Regulation Of Sequestering Of Triglyceride Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Triglyceride Catabolic Process Regulation Of GTPase Activity Mullerian Duct Regression Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Receptor Recycling Response To Cobalt Ion Golgi Vesicle Transport Short-term Memory COPI-coated Vesicle Budding Positive Regulation Of Lipoprotein Lipase Activity COPI Coating Of Golgi Vesicle Positive Regulation Of Metabolic Process
Tagcloud ?		accumulated arf arf1 arfgef caenorhabditis cdc48 cerevisiae coat contact contacts elegans evolutionarily fractionated fzo1 gem1 gtpase initiating interacted mitochondria mitochondrial mitofusin modifying resolved saccharomyces traffic unexpected vesicular worms	abhd5 agpat2 anomaly atgl cgi ctgm dgat1 diverge enteropathy gk glycerol gpd1 hsl ichthyosis inborn jordan lipe lipodystrophy loosing lpin1 lpin2 majeed nlsd perilipin pseudohypertriglyceridemia rhabdomyolysis steatosis tgs vacuolated
Tagcloud (Difference) ?		accumulated arf arf1 arfgef caenorhabditis cdc48 cerevisiae coat contact contacts elegans evolutionarily fractionated fzo1 gem1 gtpase initiating interacted mitochondria mitochondrial mitofusin modifying resolved saccharomyces traffic unexpected vesicular worms	abhd5 agpat2 anomaly atgl cgi ctgm dgat1 diverge enteropathy gk glycerol gpd1 hsl ichthyosis inborn jordan lipe lipodystrophy loosing lpin1 lpin2 majeed nlsd perilipin pseudohypertriglyceridemia rhabdomyolysis steatosis tgs vacuolated
Tagcloud (Intersection) ?