TXNDC5 and GMPPB

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		TXNDC5	GMPPB
Description		thioredoxin domain containing 5	GDP-mannose pyrophosphorylase B
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endomembrane System Azurophil Granule Lumen Lysosomal Lumen Intracellular Organelle Lumen Extracellular Exosome	Cytoplasm Cytosol GDP-mannose Pyrophosphorylase Complex
	Molecular Function	Protein Disulfide Isomerase Activity Protein Binding Protein-disulfide Reductase Activity Oxidoreductase Activity Isomerase Activity	Nucleotide Binding Mannose-1-phosphate Guanylyltransferase (GTP) Activity Protein Binding GTP Binding Transferase Activity Nucleotidyltransferase Activity Metal Ion Binding
	Biological Process	Protein Folding Negative Regulation Of Apoptotic Process	Protein Glycosylation GDP-mannose Biosynthetic Process GDP-mannose Metabolic Process GDP-mannose Biosynthetic Process From Mannose
Pathways		Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Neutrophil degranulation	Synthesis of GDP-mannose
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) High chromosomal aberration frequency (chromatid type) ( 31586183) Mean corpuscular hemoglobin ( 32888494) Pelvic organ prolapse ( 32184442)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Extremely high intelligence ( 29520040) Multisite chronic pain ( 31194737) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Resting heart rate ( 27798624) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 21297633)
Interacting Genes		29 interacting genes: APP AR BLZF1 CEBPA EDEM3 EFEMP1 FLACC1 GMPPB KRT38 KRT40 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-12 KRTAP4-2 LHX4 MGAT5B NOTCH2NLA OGT PJA1 PRDX2 RAB3IP SPRY2 TRIM23 TRIM42 TRIP6 UBQLN2	5 interacting genes: DPPA4 GLYCTK GMPPA POLR1C TXNDC5
Entrez ID		81567	29925
HPRD ID		18249	13589
Ensembl ID		ENSG00000239264	ENSG00000173540
Uniprot IDs		A0A024QZV0 Q8NBS9	Q9Y5P6
PDB IDs		2DIZ 3UJ1 3UVT 3WGD 3WGE 3WGX 8EKY	7D72 7D73 7D74
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Protein Glycosylation Macromolecule Glycosylation Glycosylation Hair Cycle	Molecular Sensor Activity GDP-mannose Pyrophosphorylase Complex Mannose-1-phosphate Guanylyltransferase (GTP) Activity Fructose Catabolic Process Fructose Catabolic Process To Hydroxyacetone Phosphate And Glyceraldehyde-3-phosphate Glycerate Kinase Activity
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