VAMP8 and STX1A

Number of citations of the paper that reports this interaction (PMID 11112705)
10

Data Source:
HPRD (in vivo, in vitro)

		VAMP8	STX1A
Gene Name		vesicle-associated membrane protein 8	syntaxin 1A (brain)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Lysosomal Membrane Early Endosome Cytosol Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Secretory Granule Membrane SNARE Complex Late Endosome Membrane Vesicle Azurophil Granule Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Vesicular Exosome Mucin Granule	Extracellular Region Cytosol Plasma Membrane Synaptic Vesicle Endomembrane System Integral Component Of Membrane Cell Junction Secretory Granule Synaptic Vesicle Membrane SNARE Complex Actomyosin Neuron Projection Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex
	Molecular Function	SNARE Binding SNAP Receptor Activity Chloride Channel Inhibitor Activity Syntaxin Binding	SNARE Binding Glycoprotein Binding SNAP Receptor Activity Protein Binding Myosin Binding Calcium Channel Inhibitor Activity Chloride Channel Inhibitor Activity Kinase Binding Protein Domain Specific Binding Protein Binding, Bridging Myosin Head/neck Binding ATP-dependent Protein Binding Protein Heterodimerization Activity Protein N-terminus Binding Calcium-dependent Protein Binding
	Biological Process	Autophagic Vacuole Fusion Exocytosis Post-Golgi Vesicle-mediated Transport Endocytosis Vesicle Fusion Protein Transport Regulation Of Endocytosis SNARE Complex Assembly Eosinophil Degranulation Neutrophil Degranulation Viral Entry Into Host Cell Membrane Organization Mucus Secretion Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Secretion By Cell Positive Regulation Of Histamine Secretion By Mast Cell	Positive Regulation Of Neurotransmitter Secretion Energy Reserve Metabolic Process Intracellular Protein Transport Synaptic Transmission Neurotransmitter Secretion Pathogenesis Response To Gravity Regulation Of Synaptic Vesicle Priming Glutamate Secretion Synaptic Vesicle Docking Calcium Ion-dependent Exocytosis Synaptic Vesicle Fusion To Presynaptic Membrane Secretion By Cell Cellular Protein Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Exocytosis Vesicle Docking Regulation Of Insulin Secretion Positive Regulation Of Excitatory Postsynaptic Membrane Potential
Pathways		Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding Lysosome Vesicle Biogenesis	Dopamine Neurotransmitter Release Cycle Integration of energy metabolism Acetylcholine Neurotransmitter Release Cycle Regulation of insulin secretion Toxicity of botulinum toxin type C (BoNT/C) Norepinephrine Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation Glutamate Neurotransmitter Release Cycle Peptide hormone metabolism Uptake and actions of bacterial toxins Neurotransmitter Release Cycle Insulin processing Serotonin Neurotransmitter Release Cycle Neurotoxicity of clostridium toxins Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Prostate cancer ( 21743467)
Protein-Protein Interactions		12 interactors: CDC25A MLH1 NAPA SNAP23 SNAP25 STX1A STX3 STX4 STX7 UBE2G2 VAMP2 VAMP3	58 interactors: ABCC9 APBA1 ATP4B ATP6V1B1 CACNA1D CCSER2 CDK5 CFTR CPLX1 CSNK2A1 CSNK2A2 DAPK1 KCNB1 NAPA NAPB NSF PSMA3 RAB27A RIMS1 SCNN1A SCNN1B SCNN1G SDCBP SEPT2 SEPT5 SLC6A1 SLC6A2 SLC6A3 SLC6A4 SLC6A5 SLC6A9 SNAP23 SNAP25 SNAP29 SNPH STX8 STXBP1 STXBP2 STXBP5 STXBP6 SUMO1P1 SYT1 SYT4 SYT7 SYTL4 TRDMT1 TXLNA TXLNB UNC13B VAMP1 VAMP2 VAMP5 VAMP7 VAMP8 VAPB VIM VPS11 VPS18
Entrez ID		8673	6804
HPRD ID		04415	01721
Ensembl ID		ENSG00000118640	ENSG00000106089
Uniprot IDs		Q9BV40	A8MZ54 Q16623 Q75ME0
PDB IDs
Enriched GO Terms of Interacting Partners?		Vesicle Fusion Membrane Fusion Organelle Fusion Synaptic Vesicle Fusion To Presynaptic Membrane Vesicle Organization Neurotransmitter Secretion Synaptic Vesicle Exocytosis Regulation Of Neurotransmitter Levels Neurotransmitter Transport Vesicle Docking Membrane Docking Organelle Localization Synaptic Vesicle Transport Membrane Organization Establishment Of Organelle Localization Exocytosis Establishment Of Vesicle Localization Vesicle Localization Post-Golgi Vesicle-mediated Transport Establishment Of Localization In Cell Secretion By Cell Positive Regulation Of Synaptic Transmission Cell-cell Signaling Vesicle-mediated Transport Regulation Of Synaptic Transmission Synaptic Transmission Regulation Of Cellular Localization Cellular Localization Secretion Long-term Synaptic Potentiation Protein Transport Intracellular Protein Transport Establishment Of Protein Localization Organelle Organization Intracellular Transport Golgi Vesicle Transport Glutamate Secretion Regulation Of Secretion Cellular Protein Complex Assembly Protein Localization Regulation Of Exocytosis Regulation Of Protein Localization Regulation Of Synaptic Plasticity Cellular Protein Localization Calcium Ion-dependent Exocytosis Regulation Of Protein Localization To Plasma Membrane Regulation Of Insulin Secretion Regulation Of Synaptic Vesicle Priming Regulation Of Peptide Hormone Secretion Acid Secretion	Exocytosis Secretion By Cell Neurotransmitter Transport Secretion Regulation Of Exocytosis Regulation Of Neurotransmitter Levels Transport Vesicle-mediated Transport Regulation Of Secretion Neurotransmitter Secretion Synaptic Transmission Cell-cell Signaling Regulation Of Vesicle-mediated Transport Establishment Of Localization In Cell Synaptic Vesicle Transport Synaptic Vesicle Exocytosis Cellular Localization Positive Regulation Of Exocytosis Regulation Of Cellular Localization Membrane Fusion Glutamate Secretion Establishment Of Vesicle Localization Vesicle Localization Ion Transport Vesicle Fusion Protein Transport Establishment Of Protein Localization Amino Acid Transport Vesicle Docking Organelle Fusion Membrane Docking Establishment Of Organelle Localization Membrane Organization Acid Secretion Vesicle Organization Positive Regulation Of Secretion Organelle Localization Protein Localization Monovalent Inorganic Cation Transport Anion Transport Dicarboxylic Acid Transport Regulated Secretory Pathway Metal Ion Transport Vesicle Docking Involved In Exocytosis Positive Regulation Of Transport Carboxylic Acid Transport Regulation Of Synaptic Transmission Organic Acid Transport Sodium Ion Transport Organic Anion Transport
Tagcloud ?		3t3 adipocytes characterised complexes consists facet finding fulfil glut4 immunoprecipitation isoforms l1 others propose sds snap23 snare subcellular syntaxin4 systematic trafficking vamp2 vamp3 vamps vary vesicle vesicles	colitis colonized died h7 hemolytic hemorrhagic hus isogenic k3995 lysogenic o157 outbreak outbreaks phage phages rabbits reflects shiga spinach stec streptomycin stx2 stx2a stx2c succumbed toxin uremic virulence
Tagcloud (Difference) ?		3t3 adipocytes characterised complexes consists facet finding fulfil glut4 immunoprecipitation isoforms l1 others propose sds snap23 snare subcellular syntaxin4 systematic trafficking vamp2 vamp3 vamps vary vesicle vesicles	colitis colonized died h7 hemolytic hemorrhagic hus isogenic k3995 lysogenic o157 outbreak outbreaks phage phages rabbits reflects shiga spinach stec streptomycin stx2 stx2a stx2c succumbed toxin uremic virulence
Tagcloud (Intersection) ?