VAMP8

Description		vesicle associated membrane protein 8
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GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Endosome Early Endosome Cytosol Plasma Membrane Membrane Secretory Granule Membrane Clathrin-coated Endocytic Vesicle Membrane Phagocytic Vesicle Membrane SNARE Complex Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Vesicle Azurophil Granule Membrane Specific Granule Membrane Zymogen Granule Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Tertiary Granule Membrane Mucin Granule
	Molecular Function	SNAP Receptor Activity Protein Binding Chloride Channel Inhibitor Activity Syntaxin Binding
	Biological Process	Vesicle Fusion Autophagy Protein Transport Vesicle-mediated Transport Autophagosome Membrane Docking SNARE Complex Assembly Eosinophil Degranulation Neutrophil Degranulation Protein-containing Complex Organization Symbiont Entry Into Host Cell Defense Response To Virus Mucus Secretion Autophagosome Maturation Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Secretion By Cell Positive Regulation Of Histamine Secretion By Mast Cell
Pathways		ER-Phagosome pathway trans-Golgi Network Vesicle Budding Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Neutrophil degranulation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Coronary artery disease ( 26343387 29212778 32469254) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Eosinophil count ( 27863252 32888494) Eosinophil percentage of white cells ( 32888494) Myocardial infarction ( 26343387) Prostate cancer ( 21743467) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		11 interacting genes: CDC25A MLH1 NAPA SNAP23 SNAP25 STX1A STX3 STX4 STX7 UBE2G2 VAMP2
Entrez ID		8673
HPRD ID		04415
Ensembl ID		ENSG00000118640
Uniprot IDs		B8ZZT4 Q9BV40
PDB IDs		4WY4 7BV6
Enriched GO Terms of Interacting Partners?		SNAP Receptor Activity SNARE Complex SNARE Binding Membrane Fusion Vesicle Fusion Organelle Membrane Fusion Organelle Fusion Membrane Organization Vesicle Organization Vesicle Docking Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Organelle Localization By Membrane Tethering Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Exocytosis Membrane Docking Positive Regulation Of Synaptic Transmission Syntaxin Binding Neuron Projection Long-term Synaptic Potentiation Azurophil Granule SNARE Complex Assembly Secretion By Cell Vesicle-mediated Transport Specific Granule Synaptic Vesicle Priming Organelle Localization Vesicle-mediated Transport In Synapse Secretion Regulation Of Protein Localization Neurotransmitter Transport Establishment Of Localization In Cell Protein Transport Synaptic Vesicle Exocytosis Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Synaptic Vesicle Calcium-ion Regulated Exocytosis Signal Release Establishment Of Protein Localization Regulation Of Protein Transport Regulation Of Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Chloride Channel Inhibitor Activity Regulation Of Cellular Localization Regulation Of Establishment Of Protein Localization Regulation Of Hormone Levels Intracellular Protein Transport Glutamatergic Synapse Voltage-gated Potassium Channel Complex Calcium-dependent Protein Binding Cellular Component Assembly
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