VAMP8 and SNAP25

Number of citations of the paper that reports this interaction (PMID 10336434)
77

Data Source:
HPRD (in vitro)

		VAMP8	SNAP25
Gene Name		vesicle-associated membrane protein 8	synaptosomal-associated protein, 25kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Lysosomal Membrane Early Endosome Cytosol Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Secretory Granule Membrane SNARE Complex Late Endosome Membrane Vesicle Azurophil Granule Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Vesicular Exosome Mucin Granule	Cytoplasm Trans-Golgi Network Cytosol Plasma Membrane Membrane Cell Junction Growth Cone BLOC-1 Complex SNARE Complex Vesicle Presynaptic Membrane Neuron Projection Perinuclear Region Of Cytoplasm Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex
	Molecular Function	SNARE Binding SNAP Receptor Activity Chloride Channel Inhibitor Activity Syntaxin Binding	SNAP Receptor Activity Protein Binding Syntaxin-1 Binding Calcium-dependent Protein Binding
	Biological Process	Autophagic Vacuole Fusion Exocytosis Post-Golgi Vesicle-mediated Transport Endocytosis Vesicle Fusion Protein Transport Regulation Of Endocytosis SNARE Complex Assembly Eosinophil Degranulation Neutrophil Degranulation Viral Entry Into Host Cell Membrane Organization Mucus Secretion Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Secretion By Cell Positive Regulation Of Histamine Secretion By Mast Cell	Neurotransmitter Uptake Energy Reserve Metabolic Process Synaptic Transmission Neurotransmitter Secretion Pathogenesis Regulation Of Neuron Projection Development Glutamate Secretion Synaptic Vesicle Exocytosis Synaptic Vesicle Docking Synaptic Vesicle Priming Synaptic Vesicle Fusion To Presynaptic Membrane Small Molecule Metabolic Process Regulation Of Insulin Secretion Long-term Synaptic Potentiation Regulation Of Establishment Of Protein Localization
Pathways		Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding Lysosome Vesicle Biogenesis	Dopamine Neurotransmitter Release Cycle Integration of energy metabolism Toxicity of botulinum toxin type E (BoNT/E) Toxicity of botulinum toxin type A (BoNT/A) Acetylcholine Neurotransmitter Release Cycle Regulation of insulin secretion Toxicity of botulinum toxin type C (BoNT/C) Norepinephrine Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation Glutamate Neurotransmitter Release Cycle Uptake and actions of bacterial toxins Neurotransmitter Release Cycle Neurotoxicity of clostridium toxins Serotonin Neurotransmitter Release Cycle Transmission across Chemical Synapses
Drugs			Botulinum Toxin Type A
Diseases
GWAS		Prostate cancer ( 21743467)	Cardiac hypertrophy ( 21348951)
Protein-Protein Interactions		12 interactors: CDC25A MLH1 NAPA SNAP23 SNAP25 STX1A STX3 STX4 STX7 UBE2G2 VAMP2 VAMP3	34 interactors: APP CCDC53 CENPF CPLX1 DNM1 GOSR1 HGS ITSN1 KCNB1 KIF5B NAPA PRKACA PRKCA PRRT2 RIMS1 SCAMP1 SNAPIN SRCIN1 STX11 STX12 STX1A STX2 STX3 STX4 STX5 STXBP6 SYT1 SYT3 SYT9 TRIM9 VAMP2 VAMP7 VAMP8 ZDHHC17
Entrez ID		8673	6616
HPRD ID		04415	02637
Ensembl ID		ENSG00000118640	ENSG00000132639
Uniprot IDs		Q9BV40	P60880
PDB IDs			1KIL 1XTG 3RK2 3RK3 3RL0 3ZUR
Enriched GO Terms of Interacting Partners?		Vesicle Fusion Membrane Fusion Organelle Fusion Synaptic Vesicle Fusion To Presynaptic Membrane Vesicle Organization Neurotransmitter Secretion Synaptic Vesicle Exocytosis Regulation Of Neurotransmitter Levels Neurotransmitter Transport Vesicle Docking Membrane Docking Organelle Localization Synaptic Vesicle Transport Membrane Organization Establishment Of Organelle Localization Exocytosis Establishment Of Vesicle Localization Vesicle Localization Post-Golgi Vesicle-mediated Transport Establishment Of Localization In Cell Secretion By Cell Positive Regulation Of Synaptic Transmission Cell-cell Signaling Vesicle-mediated Transport Regulation Of Synaptic Transmission Synaptic Transmission Regulation Of Cellular Localization Cellular Localization Secretion Long-term Synaptic Potentiation Protein Transport Intracellular Protein Transport Establishment Of Protein Localization Organelle Organization Intracellular Transport Golgi Vesicle Transport Glutamate Secretion Regulation Of Secretion Cellular Protein Complex Assembly Protein Localization Regulation Of Exocytosis Regulation Of Protein Localization Regulation Of Synaptic Plasticity Cellular Protein Localization Calcium Ion-dependent Exocytosis Regulation Of Protein Localization To Plasma Membrane Regulation Of Insulin Secretion Regulation Of Synaptic Vesicle Priming Regulation Of Peptide Hormone Secretion Acid Secretion	Membrane Fusion Exocytosis Vesicle-mediated Transport Vesicle Fusion Synaptic Vesicle Exocytosis Synaptic Vesicle Transport Establishment Of Localization In Cell Secretion By Cell Organelle Fusion Establishment Of Vesicle Localization Vesicle Localization Regulation Of Exocytosis Secretion Neurotransmitter Secretion Cellular Localization Transport Establishment Of Organelle Localization Regulation Of Cellular Localization Synaptic Transmission Regulation Of Neurotransmitter Levels Regulation Of Secretion Organelle Localization Neurotransmitter Transport Membrane Organization Regulation Of Vesicle-mediated Transport Synaptic Vesicle Fusion To Presynaptic Membrane Protein Transport Vesicle Organization Establishment Of Protein Localization Cell-cell Signaling Vesicle Docking Intracellular Transport Membrane Docking Protein Localization Positive Regulation Of Exocytosis Calcium Ion-dependent Exocytosis Regulation Of Hormone Secretion Intracellular Protein Transport Regulation Of Cellular Component Organization Positive Regulation Of Transport Glutamate Secretion Regulation Of Synaptic Transmission Golgi Vesicle Transport Post-Golgi Vesicle-mediated Transport Regulation Of Protein Localization Positive Regulation Of Synaptic Transmission Regulation Of Insulin Secretion Cellular Protein Localization Regulation Of Peptide Hormone Secretion Acid Secretion
Tagcloud ?		3t3 adipocytes characterised complexes consists facet finding fulfil glut4 immunoprecipitation isoforms l1 others propose sds snap23 snare subcellular syntaxin4 systematic trafficking vamp2 vamp3 vamps vary vesicle vesicles	anterograde axonal axons blunt breakdown bulbous bulbs caudate circumscribed disorganized immunocytochemical immunoreactivity insult map5 mca neurofilament nf68kd nonischemic occlusion permeating precedes reminiscent roughened sequalae subcortical swellings synaptosomal territory tracts
Tagcloud (Difference) ?		3t3 adipocytes characterised complexes consists facet finding fulfil glut4 immunoprecipitation isoforms l1 others propose sds snap23 snare subcellular syntaxin4 systematic trafficking vamp2 vamp3 vamps vary vesicle vesicles	anterograde axonal axons blunt breakdown bulbous bulbs caudate circumscribed disorganized immunocytochemical immunoreactivity insult map5 mca neurofilament nf68kd nonischemic occlusion permeating precedes reminiscent roughened sequalae subcortical swellings synaptosomal territory tracts
Tagcloud (Intersection) ?