KCNK5 and AQP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KCNK5	AQP1
Description		potassium two pore domain channel subfamily K member 5	aquaporin 1 (Colton blood group)
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Monoatomic Ion Channel Complex	Nucleus Cytoplasm Plasma Membrane Brush Border Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Axon Brush Border Membrane Nuclear Membrane Sarcolemma Apical Part Of Cell Extracellular Exosome Ankyrin-1 Complex
	Molecular Function	Voltage-gated Potassium Channel Activity Potassium Channel Activity Protein Binding Outward Rectifier Potassium Channel Activity Potassium Ion Leak Channel Activity Metal Ion Binding Protein Heterodimerization Activity	Intracellularly CGMP-activated Cation Channel Activity Potassium Channel Activity Water Transmembrane Transporter Activity Protein Binding Ammonium Channel Activity Potassium Ion Transmembrane Transporter Activity Glycerol Transmembrane Transporter Activity Water Channel Activity Channel Activity Transmembrane Transporter Activity Nitric Oxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transporter Activity Identical Protein Binding Ephrin Receptor Binding Hydrogen Peroxide Channel Activity
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Resting Membrane Potential Potassium Ion Transmembrane Transport Potassium Ion Export Across Plasma Membrane Potassium Ion Import Across Plasma Membrane	Renal Water Homeostasis Glomerular Filtration Renal Water Transport Potassium Ion Transport Water Transport Cell Volume Homeostasis Hyperosmotic Response Intracellular Water Homeostasis Fibroblast Migration Positive Regulation Of Fibroblast Migration Carbon Dioxide Transport Glycerol Transmembrane Transport Cell Migration Sensory Perception Of Pain Cellular Homeostasis CGMP-mediated Signaling Lateral Ventricle Development Pancreatic Juice Secretion Nitric Oxide Transport Establishment Or Maintenance Of Actin Cytoskeleton Polarity Secretion By Cell Cerebrospinal Fluid Secretion Secretory Granule Organization Cellular Response To UV Transepithelial Water Transport Carbon Dioxide Transmembrane Transport Wound Healing Odontogenesis Negative Regulation Of Apoptotic Process Lipid Digestion Positive Regulation Of Angiogenesis Positive Regulation Of Saliva Secretion Positive Regulation Of Fibroblast Proliferation Camera-type Eye Morphogenesis Defense Response To Gram-negative Bacterium Multicellular Organismal-level Water Homeostasis Corticotropin Secretion Establishment Of Localization In Cell Transmembrane Transport Renal Water Absorption Cellular Response To Hydrogen Peroxide Cellular Response To Mechanical Stimulus Cellular Response To Copper Ion Cellular Response To Mercury Ion Cellular Response To Retinoic Acid Cellular Response To CAMP Cellular Response To Hypoxia Cellular Response To Salt Stress Cellular Hyperosmotic Response Cellular Response To Dexamethasone Stimulus Cellular Response To Nitric Oxide Potassium Ion Transmembrane Transport Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Metanephric Proximal Convoluted Tubule Segment 2 Development Metanephric Glomerulus Vasculature Development Ammonium Transmembrane Transport Hydrogen Peroxide Transmembrane Transport Monoatomic Cation Transmembrane Transport
Pathways		Phase 4 - resting membrane potential	Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins Developmental Lineage of Pancreatic Ductal Cells
Drugs			Acetazolamide B-nonylglucoside Mersalyl
Diseases
GWAS		Albuminuria ( 30547231) Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Coronary artery disease ( 26343387 29212778 33020668 32469254) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 27841878) Eating disorders ( 23568457) Fasting plasma glucose ( 32682390) HDL cholesterol levels ( 32203549) Hypertension in type 2 diabetes ( 33276381) Kidney stones ( 31729369) Migraine ( 27322543) Myocardial infarction ( 33532862 26343387) Obesity-related traits ( 23251661) Social communication problems ( 24564958) Urinary albumin-to-creatinine ratio ( 31630189 31511532) Urolithiasis ( 30975718)	Fractures ( 30598549) Heel bone mineral density ( 28869591 30598549) hemolysis of donated blood (osmotic) ( 34014839) Huntington's disease progression ( 28642124) Kidney stones ( 31729369) Nephrolithiasis ( 22396660) Systolic blood pressure ( 30224653) Total body bone mineral density ( 29304378) Triglyceride levels ( 34074324) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		29 interacting genes: ADIPOQ AGTRAP APP AQP1 ATP5PF BNIP2 CMTM5 COMT CYB5B FRAT1 GJB2 IGFBP5 LHFPL5 MAN2B2 ORMDL3 SLC66A2 SMCO4 STRIT1 TM4SF4 TMEM128 TMEM14A TMEM176A TMEM218 TMEM54 TMEM60 TNFRSF10C TSPAN33 VAMP3 YIPF6	134 interacting genes: ADAMTSL4 AMOT AQP6 BCL2L13 BEGAIN BLZF1 BMF CCDC136 CCDC57 CCDC85B CCNDBP1 CD79A CDR2 CEP44 CLDN5 COMP CPLX4 CREB3 CRTAC1 CSRNP1 CYSRT1 EFEMP2 EPHB2 ESM1 EVI2B FAM161A FAM209A FNDC9 FOS FSD2 GET1 GJB5 GLI1 GOLGA2 GPR37L1 GPRASP3 GPX8 IFT20 IGFBP6 IHO1 IKZF2 IKZF3 IL21R KCNK5 KCTD17 KCTD9 KHDRBS3 KIAA1958 KLHL26 KRT31 KRT33B KRT37 KRT40 KRTAP1-1 KRTAP1-5 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP12-4 KRTAP3-2 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP6-2 KRTAP9-2 KRTAP9-8 LCE1A LDLRAD1 LDOC1 LIME1 LMNA LPXN LRRC59 MDFI MGST3 MID2 MIF4GD MKRN3 MRM1 MTUS2 MUC1 MYF5 NBPF19 NBPF22P NBPF6 NOTCH2NLA NUTM1 PGPEP1 PICK1 PLA2G10 PLSCR2 PPARA PRDM14 PRDM6 RBAK REL RGS17 RGS20 RIMBP3 RNF122 SAR1A SIAH1 SIVA1 SLC15A2 SLC39A2 SPDYA SPRED1 SPRED2 SPRY2 SPRY3 SPRYD7 SSMEM1 TCF4 TMEM237 TMEM38B TMEM45B TMEM80 TMPRSS2 TNK2 TNS2 TRAF1 TRAF2 TRIM23 TRIM37 TRIM41 TRIM42 TRIM7 TRIP6 TSC1 ZBTB39 ZIM2 ZNF16 ZNF398 ZNF792
Entrez ID		8645	358
HPRD ID		04604	00140
Ensembl ID		ENSG00000164626	ENSG00000240583
Uniprot IDs		A0A0B6VPR3 O95279	A0A024RA31 P29972
PDB IDs			1FQY 1H6I 1IH5 4CSK 6POJ 7UZE 8CT2 8CTE
Enriched GO Terms of Interacting Partners?		Membrane Cellular Response To CAMP Response To CAMP Response To Purine-containing Compound Response To Decreased Oxygen Levels	Intermediate Filament Keratin Filament Protein Binding Identical Protein Binding Negative Regulation Of Lens Fiber Cell Differentiation Hair Cycle Regulation Of Lens Fiber Cell Differentiation Tumor Necrosis Factor Receptor Binding Cellular Developmental Process
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