KCNK5 and MAN2B2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KCNK5	MAN2B2
Description		potassium two pore domain channel subfamily K member 5	mannosidase alpha class 2B member 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Monoatomic Ion Channel Complex	Extracellular Region Lysosome Lysosomal Lumen Extracellular Exosome
	Molecular Function	Voltage-gated Potassium Channel Activity Potassium Channel Activity Protein Binding Outward Rectifier Potassium Channel Activity Potassium Ion Leak Channel Activity Metal Ion Binding Protein Heterodimerization Activity	Catalytic Activity Alpha-mannosidase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Carbohydrate Binding Metal Ion Binding Mannosyl-oligosaccharide 1,6-alpha-mannosidase Activity
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Resting Membrane Potential Potassium Ion Transmembrane Transport Potassium Ion Export Across Plasma Membrane Potassium Ion Import Across Plasma Membrane	Carbohydrate Metabolic Process Mannose Metabolic Process Glycoprotein Catabolic Process Oligosaccharide Catabolic Process
Pathways		Phase 4 - resting membrane potential	Lysosomal oligosaccharide catabolism
Drugs
Diseases
GWAS		Albuminuria ( 30547231) Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Coronary artery disease ( 26343387 29212778 33020668 32469254) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 27841878) Eating disorders ( 23568457) Fasting plasma glucose ( 32682390) HDL cholesterol levels ( 32203549) Hypertension in type 2 diabetes ( 33276381) Kidney stones ( 31729369) Migraine ( 27322543) Myocardial infarction ( 33532862 26343387) Obesity-related traits ( 23251661) Social communication problems ( 24564958) Urinary albumin-to-creatinine ratio ( 31630189 31511532) Urolithiasis ( 30975718)	Blood protein levels ( 30072576) Metabolite levels ( 23823483)
Interacting Genes		29 interacting genes: ADIPOQ AGTRAP APP AQP1 ATP5PF BNIP2 CMTM5 COMT CYB5B FRAT1 GJB2 IGFBP5 LHFPL5 MAN2B2 ORMDL3 SLC66A2 SMCO4 STRIT1 TM4SF4 TMEM128 TMEM14A TMEM176A TMEM218 TMEM54 TMEM60 TNFRSF10C TSPAN33 VAMP3 YIPF6	9 interacting genes: APPBP2 CISD2 CPLX4 CREB3L1 FKBP7 GPX8 KCNK5 KRTAP3-2 LIME1
Entrez ID		8645	23324
HPRD ID		04604	14355
Ensembl ID		ENSG00000164626	ENSG00000013288
Uniprot IDs		A0A0B6VPR3 O95279	B7Z754 E9PCD7 Q9Y2E5
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Cellular Response To CAMP Response To CAMP Response To Purine-containing Compound Response To Decreased Oxygen Levels
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