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KIAA0408 and KDM1A
Number of citations of the paper that reports this interaction (PMID
23455924
)
3
Data Source:
BioGRID
(two hybrid)
KIAA0408
KDM1A
Gene Name
KIAA0408
lysine (K)-specific demethylase 1A
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nuclear Chromatin
Nucleus
Nucleoplasm
Transcription Factor Complex
Molecular Function
Protein Binding
RNA Polymerase II Transcription Factor Binding
P53 Binding
Chromatin Binding
Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Oxidoreductase Activity
Enzyme Binding
Ligand-dependent Nuclear Receptor Transcription Coactivator Activity
Demethylase Activity
Histone Demethylase Activity
Histone Demethylase Activity (H3-K4 Specific)
Histone Demethylase Activity (H3-K9 Specific)
Histone Demethylase Activity (H3-dimethyl-K4 Specific)
MRF Binding
Transcription Regulatory Region DNA Binding
Flavin Adenine Dinucleotide Binding
Androgen Receptor Binding
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
In Utero Embryonic Development
Chromatin Organization
Transcription, DNA-templated
Regulation Of Transcription From RNA Polymerase II Promoter
Protein Demethylation
Blood Coagulation
Cell Proliferation
Regulation Of Primitive Erythrocyte Differentiation
Pituitary Gland Development
Granulocyte Differentiation
Negative Regulation Of Protein Binding
Histone H3-K9 Demethylation
Histone H3-K4 Demethylation
Negative Regulation Of DNA Binding
Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Hormone Biosynthetic Process
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Negative Regulation Of Histone H3-K4 Methylation
Negative Regulation Of Histone H3-K9 Methylation
Muscle Cell Development
Oxidation-reduction Process
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Positive Regulation Of Neural Precursor Cell Proliferation
Positive Regulation Of Stem Cell Proliferation
Pathways
Chromatin modifying enzymes
HDACs deacetylate histones
Chromatin organization
HDMs demethylate histones
Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS
Protein-Protein Interactions
26 interactors:
ABI3
AP2B1
BEGAIN
CARD9
CCDC85B
CEP72
DCTN1
DTNBP1
GFAP
HOOK2
KDM1A
KRT15
MAGEA11
MDFI
PFDN1
PRMT6
SFN
SORBS3
TEX11
TLE1
TRAF2
TRIM37
VIM
XRCC6
YWHAG
ZDHHC17
219 interactors:
AKAP9
ANKEF1
AP1G2
AR
ARHGAP15
ARHGAP29
ASB10
ASB3
ASCC2
ATP5J2
ATP6V1B1
BAHD1
BAIAP2
BATF
BCAT1
BLZF1
BMP3
BRCA1
C16orf59
C17orf82
C18orf54
C4orf17
C8orf48
C8orf74
CCDC121
CCDC14
CCDC151
CCDC155
CCDC172
CCDC37
CCDC53
CCDC74A
CCDC74B
CCDC90B
CDC23
CDC5L
CDCA4
CDCA5
CENPQ
CEP162
CEP70
CRBN
CRLF3
CTBP1
DBF4B
DNAJA3
DNTTIP1
DYX1C1
E2F1
ECI2
ELOF1
EXOC1
EZH2
FAM9A
FIGNL1
FYCO1
FYN
GABPB2
GDF9
GLYR1
GOLGA2
GPATCH2L
GSTCD
GTPBP2
H3F3C
HAUS1
HAUS3
HAUS6
HDAC1
HESX1
HIST1H3A
HIST2H3C
HIST3H3
HOXA1
ID2
IFI35
IGFBP4
IK
IKBIP
IL16
IMMT
INTS2
ISL1
ITGB3BP
ITSN2
KANSL1
KDM5B
KIAA0408
KIFC3
KLC3
KLF3
KLHDC4
KRT17
KRT19
KRT222
KRT33B
KRT38
KRT6A
KRT6B
KRT7
L3MBTL3
LENG8
LOXL4
MALT1
MBD3
MBD4
MCPH1
MCRS1
MLC1
MNS1
MTA3
MTF2
MTMR9
MTO1
MYC
MYLIP
NBPF15
NDUFA8
NDUFS1
NECAB2
NEFL
NF2
NMI
NOSTRIN
NR1H2
NR1H3
NR2C2
NR2E1
OFCC1
OIP5
OPA3
OTUB1
PDCD5
PDE4DIP
PEX7
PHC2
PHF19
PHF20L1
PHF21A
PMF1
PNKP
PPARD
PPP1R12A
PRDM1
PRIM2
PSMC1
PSMC3
RASSF1
RASSF2
RASSF8
RCOR1
RCOR3
RNF10
RPRD1A
SAMD3
SEPT6
SERGEF
SETDB1
SF3B2
SH3GLB2
SLU7
SMAD9
SMARCD1
SMN1
SNF8
SNX15
SOCS6
SPATA22
SPATA24
SPICE1
SPRY2
SPSB1
SPZ1
SRGAP3
SSX2IP
STAT3
STX11
STX19
SUMO1
SUMO2
SUV39H1
TACC1
TADA3
TAL1
TDO2
TERF1
TEX35
TEX9
TNFAIP1
TNNT2
TP53
TRAF4
TRIM39
TRIM54
TSACC
TSC1
TTC33
UBA3
UCHL5
UNC119
UNKL
USP28
VPS11
VPS37A
WBSCR27
WDR83
YEATS4
ZBTB24
ZCCHC17
ZFP28
ZNF280A
ZNF333
ZNF436
ZNF451
ZNF480
ZNF581
ZNF641
ZNF71
ZNF829
Entrez ID
9729
23028
HPRD ID
17187
09800
Ensembl ID
ENSG00000004487
Uniprot IDs
Q6ZU52
O60341
PDB IDs
2COM
2DW4
2EJR
2H94
2HKO
2IW5
2L3D
2UXN
2UXX
2V1D
2X0L
2XAF
2XAG
2XAH
2XAJ
2XAQ
2XAS
2Y48
2Z3Y
2Z5U
3ABT
3ABU
3ZMS
3ZMT
3ZMU
3ZMV
3ZMZ
3ZN0
3ZN1
Enriched GO Terms of Interacting Partners
?
Organelle Organization
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Bergmann Glial Cell Differentiation
Regulation Of Signaling
Negative Regulation Of Cellular Metabolic Process
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
Regulation Of Signal Transduction
Developmental Process
System Development
Anatomical Structure Development
Intermediate Filament Organization
Positive Regulation Of Signal Transduction
Astrocyte Development
G2/M Transition Of Mitotic Cell Cycle
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Regulation Of Phosphorylation
Positive Regulation Of JNK Cascade
Nervous System Development
Multicellular Organismal Development
Positive Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Regulation Of Cellular Process
Regulation Of Apoptotic Process
Regulation Of Cellular Component Organization
Regulation Of Phosphorus Metabolic Process
Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Regulation Of JNK Cascade
Cellular Response To Stress
Regulation Of Metabolic Process
Regulation Of Cell Death
Intermediate Filament Cytoskeleton Organization
Regulation Of Protein Kinase Activity
Cytoskeleton Organization
Regulation Of Cell Differentiation
Astrocyte Differentiation
Protein Autoubiquitination
Regulation Of Stress-activated MAPK Cascade
Intermediate Filament-based Process
Negative Regulation Of DNA Binding
Positive Regulation Of MAPK Cascade
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Kinase Activity
Positive Regulation Of Apoptotic Signaling Pathway
Regulation Of Primitive Erythrocyte Differentiation
Positive Regulation Of Schwann Cell Proliferation
Positive Regulation Of Intracellular Signal Transduction
Cell Cycle
Nucleobase-containing Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Transcription, DNA-templated
RNA Biosynthetic Process
Nitrogen Compound Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Metabolic Process
Organelle Organization
Gene Expression
RNA Metabolic Process
Mitotic Cell Cycle
Cell Cycle Process
Regulation Of Gene Expression
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Transcription, DNA-templated
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Mitotic Cell Cycle Process
Chromosome Organization
Negative Regulation Of Biosynthetic Process
Chromatin Organization
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription, DNA-templated
Chromatin Modification
Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Process
Negative Regulation Of Gene Expression
Negative Regulation Of Cellular Metabolic Process
Regulation Of Cell Cycle
Positive Regulation Of Metabolic Process
Regulation Of Chromosome Organization
Negative Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Cellular Metabolic Process
Cellular Metabolic Process
Regulation Of Cellular Component Organization
Biosynthetic Process
Regulation Of Cellular Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Developmental Process
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Protein Modification By Small Protein Conjugation
Tagcloud
?
aml
blasts
ccaat
confers
corepressor
corest
demethylase
demethylates
depleted
di
engrafted
engraftment
exhibiting
h3k4me3
hdi
lsd1
mark
me2
mono
npm1
oncoproteins
pan
panobinostat
permissive
ps
shrna
sp2509
synergistically
warranting
Tagcloud (Difference)
?
aml
blasts
ccaat
confers
corepressor
corest
demethylase
demethylates
depleted
di
engrafted
engraftment
exhibiting
h3k4me3
hdi
lsd1
mark
me2
mono
npm1
oncoproteins
pan
panobinostat
permissive
ps
shrna
sp2509
synergistically
warranting
Tagcloud (Intersection)
?