USO1 and HLF

		USO1	HLF
Description		USO1 vesicle transport factor	HLF transcription factor, PAR bZIP family member
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Fibrillar Center Cytoplasm Endoplasmic Reticulum Golgi Apparatus Golgi Stack Microtubule Organizing Center Cytosol ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Perinuclear Region Of Cytoplasm	Chromatin Nucleus Nucleoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Binding Protein Binding Cadherin Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Organization Small GTPase-mediated Signal Transduction Protein Transport Vesicle-mediated Transport Secretory Granule Localization Transcytosis Golgi Vesicle Transport Golgi Vesicle Docking Vesicle Fusion With Golgi Apparatus Membrane Fusion Regulation Of Cellular Response To Insulin Stimulus	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process
Pathways		Golgi Cisternae Pericentriolar Stack Reorganization COPII-mediated vesicle transport COPI-mediated anterograde transport
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261) Subjective response to lithium treatment in bipolar disorder ( 26503763)	Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced) ( 24236485) Bipolar disorder ( 31043756 33263727) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494) Hemoglobin ( 32888494) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Platelet distribution width ( 32888494) Red blood cell count ( 32888494) Serum uric acid levels ( 30993211) Urate levels ( 23263486 31578528 31985003) Urate levels in obese individuals ( 25811787) Waist circumference ( 28552196) Weight ( 28552196) Zinc levels ( 26025379)
Interacting Genes		33 interacting genes: AKAP9 BET1L BYSL C1orf94 CASP3 CASP8 CSNK2B DUSP12 EEA1 GABPB1 GAK GBF1 GOLGA2 GOLGB1 GOSR1 GOSR2 LENG1 MORF4L1 NSF PHYKPL PLCG1 PRPF6 RAB1A RNF10 RPL9 SCFD1 SF1 SNW1 STX5 STXBP1 UTP14A XPO7 YKT6	6 interacting genes: BMAL1 CREBBP DBP HNF4G MYB TET2
Entrez ID		8615	3131
HPRD ID		09135	00797
Ensembl ID		ENSG00000138768	ENSG00000108924
Uniprot IDs		O60763	Q16534
PDB IDs		2W3C
Enriched GO Terms of Interacting Partners?		Golgi Vesicle Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cis-Golgi Network Golgi Stack SNAP Receptor Activity Membrane Fusion Intracellular Transport Golgi Membrane SNARE Complex Golgi Organization Golgi Disassembly Golgi Apparatus Cytosolic Transport Vesicle-mediated Transport Cellular Localization Protein Transport Establishment Of Localization In Cell Retrograde Transport, Endosome To Golgi Syntaxin Binding Intracellular Protein Localization Establishment Of Protein Localization SNARE Binding Cytosol Endosomal Transport Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Extrinsic Component Of Postsynaptic Density Membrane Vesicle Organization Intra-Golgi Vesicle-mediated Transport Vesicle Fusion Response To Anesthetic Post-Golgi Vesicle-mediated Transport Organelle Membrane Fusion Death-inducing Signaling Complex Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Positive Regulation Of Pyroptotic Inflammatory Response Organelle Fusion Response To Cobalt Ion Vesicle Docking Membrane Organization Organelle Organization Golgi Cisterna Membrane Death Receptor Binding Regulation Of Golgi Organization Organelle Localization By Membrane Tethering Organelle Disassembly Syntaxin-1 Binding Positive Regulation Of Glycoprotein Metabolic Process Intracellular Protein Transport Membrane Docking Execution Phase Of Apoptosis	Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity Positive Regulation Of RNA Metabolic Process Golgi Vesicle Docking Icosanoid Transmembrane Transporter Activity Glucuronoside Transmembrane Transporter Activity Glucuronoside Transport Energy Homeostasis Histone H3K27 Acetyltransferase Activity Positive Regulation Of Hepatic Stellate Cell Proliferation Myosin II Heavy Chain Binding Oxidative Stress-induced Premature Senescence Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Positive Regulation Of Testosterone Secretion DNA 5-methylcytosine Dioxygenase Activity
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