USO1 and DUSP12

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		USO1	DUSP12
Description		USO1 vesicle transport factor	dual specificity phosphatase 12
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GO Annotations	Cellular Component	Golgi Membrane Fibrillar Center Cytoplasm Endoplasmic Reticulum Golgi Apparatus Golgi Stack Microtubule Organizing Center Cytosol ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Binding Protein Binding Cadherin Binding	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Zinc Ion Binding Hydrolase Activity Phosphatase Activity Kinase Binding Metal Ion Binding
	Biological Process	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Organization Small GTPase-mediated Signal Transduction Protein Transport Vesicle-mediated Transport Secretory Granule Localization Transcytosis Golgi Vesicle Transport Golgi Vesicle Docking Vesicle Fusion With Golgi Apparatus Membrane Fusion Regulation Of Cellular Response To Insulin Stimulus	Dephosphorylation Protein Modification Process
Pathways		Golgi Cisternae Pericentriolar Stack Reorganization COPII-mediated vesicle transport COPI-mediated anterograde transport
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261) Subjective response to lithium treatment in bipolar disorder ( 26503763)	Albumin-globulin ratio ( 29403010) Immunoglobulin measurement (zinc sulfate turbidity test) ( 29403010) Non-albumin protein levels ( 29403010) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		33 interacting genes: AKAP9 BET1L BYSL C1orf94 CASP3 CASP8 CSNK2B DUSP12 EEA1 GABPB1 GAK GBF1 GOLGA2 GOLGB1 GOSR1 GOSR2 LENG1 MORF4L1 NSF PHYKPL PLCG1 PRPF6 RAB1A RNF10 RPL9 SCFD1 SF1 SNW1 STX5 STXBP1 UTP14A XPO7 YKT6	14 interacting genes: APP CALCOCO2 CCNH CEP126 EIF5 HSPB8 M6PR MBD6 NR1H2 PPP2R3B PTN RABAC1 SRC USO1
Entrez ID		8615	11266
HPRD ID		09135	05323
Ensembl ID		ENSG00000138768	ENSG00000081721
Uniprot IDs		O60763	Q9UNI6
PDB IDs		2W3C	4JNB 4KI9
Enriched GO Terms of Interacting Partners?		Golgi Vesicle Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cis-Golgi Network Golgi Stack SNAP Receptor Activity Membrane Fusion Intracellular Transport Golgi Membrane SNARE Complex Golgi Organization Golgi Disassembly Golgi Apparatus Cytosolic Transport Vesicle-mediated Transport Cellular Localization Protein Transport Establishment Of Localization In Cell Retrograde Transport, Endosome To Golgi Syntaxin Binding Intracellular Protein Localization Establishment Of Protein Localization SNARE Binding Cytosol Endosomal Transport Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Extrinsic Component Of Postsynaptic Density Membrane Vesicle Organization Intra-Golgi Vesicle-mediated Transport Vesicle Fusion Response To Anesthetic Post-Golgi Vesicle-mediated Transport Organelle Membrane Fusion Death-inducing Signaling Complex Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Positive Regulation Of Pyroptotic Inflammatory Response Organelle Fusion Response To Cobalt Ion Vesicle Docking Membrane Organization Organelle Organization Golgi Cisterna Membrane Death Receptor Binding Regulation Of Golgi Organization Organelle Localization By Membrane Tethering Organelle Disassembly Syntaxin-1 Binding Positive Regulation Of Glycoprotein Metabolic Process Intracellular Protein Transport Membrane Docking Execution Phase Of Apoptosis	Signaling Receptor Activator Activity Negative Regulation Of Long-term Synaptic Potentiation Perinuclear Region Of Cytoplasm Molecular Function Activator Activity Response To Auditory Stimulus Positive Regulation Of Glycolytic Process Integrin Binding Ephrin Receptor Binding Positive Regulation Of Small Molecule Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Catabolic Process Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of ATP Metabolic Process Positive Regulation Of Toll Signaling Pathway Regulation Of Long-term Synaptic Potentiation Dendrite Development Oogenesis Positive Regulation Of Secretion Of Lysosomal Enzymes Golgi Vesicle Docking Acetylcholine Receptor Activator Activity Positive Regulation Of Cellular Component Organization PTB Domain Binding Response To Interleukin-1 Regulation Of ATP Metabolic Process Collateral Sprouting In Absence Of Injury Myeloid Cell Development Regulation Of Protein Import Regulation Of Carbohydrate Catabolic Process Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Small Molecule Metabolic Process Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Endocytosis Transcription Factor TFIIK Complex Cadherin Binding Eukaryotic Initiation Factor EIF2 Binding Female Gamete Generation Dendrite Regeneration Ossification Involved In Bone Remodeling
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