HLF and ARNTL

Number of citations of the paper that reports this interaction (PMID 9704006)
10

Data Source:
HPRD (two hybrid, in vitro)

		HLF	ARNTL
Gene Name		hepatic leukemia factor	aryl hydrocarbon receptor nuclear translocator-like
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Transcription Factor Complex PML Body Chromatoid Body
	Molecular Function	DNA Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Core Promoter Sequence-specific DNA Binding Core Promoter Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Signal Transducer Activity Protein Binding Aryl Hydrocarbon Receptor Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Protein Heterodimerization Activity Hsp90 Protein Binding E-box Binding
	Biological Process	Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Skeletal Muscle Cell Differentiation Rhythmic Process	Protein Import Into Nucleus, Translocation Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Signal Transduction Spermatogenesis Circadian Rhythm Negative Regulation Of TOR Signaling Circadian Regulation Of Gene Expression Regulation Of Protein Catabolic Process Regulation Of Hair Cycle Positive Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Neurogenesis Regulation Of Insulin Secretion Regulation Of Cell Cycle Response To Redox State Positive Regulation Of Canonical Wnt Signaling Pathway Oxidative Stress-induced Premature Senescence Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glucocorticoid Receptor Signaling Pathway Regulation Of Cellular Senescence Positive Regulation Of Skeletal Muscle Cell Differentiation
Pathways			PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) REV-ERBA represses gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression RORA activates circadian gene expression
Drugs
Diseases
GWAS		Urate levels ( 23263486)	Menarche (age at onset) ( 21102462) Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020) Schizophrenia ( 23358160)
Protein-Protein Interactions		5 interactors: ARNTL CREBBP DBP HNF4G MYB	20 interactors: AHR BHLHE40 CLOCK CRY1 CSNK1E EP300 EPAS1 HIF1A HLF HSP90AA1 KAT2B NPAS2 NPAS4 PER3 RARA RXRA SIRT1 SUMO2 SUMO3 UBE2I
Entrez ID		3131	406
HPRD ID		00797	03973
Ensembl ID		ENSG00000108924	ENSG00000133794
Uniprot IDs		A8K1X8 Q16534 Q6FHS9	O00327
PDB IDs			4H10
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process RNA Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Anatomical Structure Development Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Circadian Rhythm Transcription Initiation From RNA Polymerase II Promoter N-terminal Peptidyl-lysine Acetylation Developmental Process Nitrogen Compound Metabolic Process Oxidative Stress-induced Premature Senescence DNA-templated Transcription, Initiation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Skeletal Muscle Cell Differentiation Germ-line Stem Cell Maintenance Stress-induced Premature Senescence Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Glucocorticoid Receptor Signaling Pathway Response To Redox State Regulation Of Type B Pancreatic Cell Development N-terminal Protein Amino Acid Acetylation Regulation Of Cell Differentiation Positive Regulation Of Histone H3-K9 Methylation	Rhythmic Process Circadian Regulation Of Gene Expression Circadian Rhythm Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process RNA Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Peptidyl-lysine Modification Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cellular Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Biosynthetic Process Peptidyl-amino Acid Modification Signal Transduction Protein Sumoylation Regulation Of Cellular Process Regulation Of Circadian Rhythm Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Photoperiodism Cellular Response To Hypoxia Response To Abiotic Stimulus
Tagcloud ?		adenovirus ahr arises arnt arnt2 aromatic aryl bhlh cbp conveys dioxin e1a extensively gst heterodimer hybrid hydrocarbon hydrocarbons interacted metabolizing methylcholanthrene partner pas pull sim somehow tetrachlorodibenzo transactivation translocator	244k agilent bisulfite chemosensitivity chip circadian clock cobra cp70 cpg deadly epigenetically fifth gsk126 gynecological h3k27me3 hallmark hypermethylation island mark mcp2 medip methylated microarray ovarian repressive restored rhythmic silenced
Tagcloud (Difference) ?		adenovirus ahr arises arnt arnt2 aromatic aryl bhlh cbp conveys dioxin e1a extensively gst heterodimer hybrid hydrocarbon hydrocarbons interacted metabolizing methylcholanthrene partner pas pull sim somehow tetrachlorodibenzo transactivation translocator	244k agilent bisulfite chemosensitivity chip circadian clock cobra cp70 cpg deadly epigenetically fifth gsk126 gynecological h3k27me3 hallmark hypermethylation island mark mcp2 medip methylated microarray ovarian repressive restored rhythmic silenced
Tagcloud (Intersection) ?