USO1 and GAK

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		USO1	GAK
Description		USO1 vesicle transport factor	cyclin G associated kinase
Image
GO Annotations	Cellular Component	Golgi Membrane Fibrillar Center Cytoplasm Endoplasmic Reticulum Golgi Apparatus Golgi Stack Microtubule Organizing Center Cytosol ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Perinuclear Region Of Cytoplasm	Cytoplasm Golgi Apparatus Cytosol Focal Adhesion Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Anchoring Junction Presynapse
	Molecular Function	RNA Binding Protein Binding Cadherin Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Clathrin Binding Cyclin Binding Protein Folding Chaperone Protein Serine Kinase Activity
	Biological Process	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Organization Small GTPase-mediated Signal Transduction Protein Transport Vesicle-mediated Transport Secretory Granule Localization Transcytosis Golgi Vesicle Transport Golgi Vesicle Docking Vesicle Fusion With Golgi Apparatus Membrane Fusion Regulation Of Cellular Response To Insulin Stimulus	Protein Folding Receptor-mediated Endocytosis Endoplasmic Reticulum Organization Golgi Organization Negative Regulation Of Neuron Projection Development Synaptic Vesicle Uncoating Protein Localization To Golgi Apparatus Intracellular Transport Clathrin Coat Assembly Clathrin Coat Disassembly Clathrin-dependent Endocytosis Protein Localization To Plasma Membrane Golgi To Lysosome Transport Regulation Of Clathrin Coat Assembly
Pathways		Golgi Cisternae Pericentriolar Stack Reorganization COPII-mediated vesicle transport COPI-mediated anterograde transport	Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis
Drugs			Fostamatinib
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261) Subjective response to lithium treatment in bipolar disorder ( 26503763)	A body shape index ( 34021172) HDL cholesterol ( 30275531) Mortality in sepsis ( 27639821) Parkinson's disease ( 20711177 32310270 27182965 25064009 22438815 21738487 21292315) Parkinson's disease (age of onset) ( 30957308) Parkinson's disease (familial) ( 18985386) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Primary biliary cholangitis ( 26394269) Triglycerides ( 30275531) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		33 interacting genes: AKAP9 BET1L BYSL C1orf94 CASP3 CASP8 CSNK2B DUSP12 EEA1 GABPB1 GAK GBF1 GOLGA2 GOLGB1 GOSR1 GOSR2 LENG1 MORF4L1 NSF PHYKPL PLCG1 PRPF6 RAB1A RNF10 RPL9 SCFD1 SF1 SNW1 STX5 STXBP1 UTP14A XPO7 YKT6	14 interacting genes: AP1M1 AP1M2 AP2M1 APP AR AXIN1 CCNG1 CDK5 CLTC CREBBP HSPA8 LRRK1 MFHAS1 USO1
Entrez ID		8615	2580
HPRD ID		09135	03631
Ensembl ID		ENSG00000138768	ENSG00000178950
Uniprot IDs		O60763	B4DS37 O14976
PDB IDs		2W3C	4C57 4C58 4C59 4O38 4Y8D 5Y7Z 5Y80
Enriched GO Terms of Interacting Partners?		Golgi Vesicle Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cis-Golgi Network Golgi Stack SNAP Receptor Activity Membrane Fusion Intracellular Transport Golgi Membrane SNARE Complex Golgi Organization Golgi Disassembly Golgi Apparatus Cytosolic Transport Vesicle-mediated Transport Cellular Localization Protein Transport Establishment Of Localization In Cell Retrograde Transport, Endosome To Golgi Syntaxin Binding Intracellular Protein Localization Establishment Of Protein Localization SNARE Binding Cytosol Endosomal Transport Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Extrinsic Component Of Postsynaptic Density Membrane Vesicle Organization Intra-Golgi Vesicle-mediated Transport Vesicle Fusion Response To Anesthetic Post-Golgi Vesicle-mediated Transport Organelle Membrane Fusion Death-inducing Signaling Complex Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Positive Regulation Of Pyroptotic Inflammatory Response Organelle Fusion Response To Cobalt Ion Vesicle Docking Membrane Organization Organelle Organization Golgi Cisterna Membrane Death Receptor Binding Regulation Of Golgi Organization Organelle Localization By Membrane Tethering Organelle Disassembly Syntaxin-1 Binding Positive Regulation Of Glycoprotein Metabolic Process Intracellular Protein Transport Membrane Docking Execution Phase Of Apoptosis	Intracellular Transport Intracellular Protein Transport Clathrin Adaptor Complex Regulation Of Protein Localization Clathrin Adaptor Activity Acetylcholine Receptor Activator Activity Negative Regulation Of Protein Localization Cellular Localization Establishment Of Localization In Cell Low-density Lipoprotein Particle Receptor Binding Regulation Of Protein Import Trans-Golgi Network Membrane Regulation Of Protein Localization To Plasma Membrane Cytoplasmic Vesicle Clathrin Coat Disassembly Regulation Of Protein Localization To Cell Periphery Vesicle Uncoating Regulation Of Protein Localization To Membrane Protein Transport Vesicle-mediated Transport Clathrin-coated Pit P53 Binding Clathrin-coated Vesicle Establishment Of Protein Localization AP-1 Adaptor Complex Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of JNK Cascade Negative Regulation Of RNA Metabolic Process Ubiquitin Protein Ligase Binding Endolysosome Membrane Transcytosis Cytosol Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Serine/threonine Kinase Binding Clathrin-coated Endocytic Vesicle Negative Regulation Of Macromolecule Biosynthetic Process Disordered Domain Specific Binding Regulation Of JNK Cascade Regulation Of Proteolysis Negative Regulation Of Biosynthetic Process Positive Regulation Of Receptor Internalization Lysosomal Membrane Regulation Of Synaptic Vesicle Recycling Negative Regulation Of Protein Localization To Plasma Membrane Enzyme Binding Regulation Of Protein Localization To Nucleus Clathrin-dependent Endocytosis Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Component Assembly
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