USO1 and YKT6

Number of citations of the paper that reports this interaction (PubMedID 11927603)
55

Data Source:
BioGRID (biochemical)
HPRD (in vivo)

		USO1	YKT6
Description		USO1 vesicle transport factor	YKT6 vesicular SNARE protein
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GO Annotations	Cellular Component	Golgi Membrane Fibrillar Center Cytoplasm Endoplasmic Reticulum Golgi Apparatus Golgi Stack Microtubule Organizing Center Cytosol ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Perinuclear Region Of Cytoplasm	Golgi Membrane Cytoplasm Mitochondrion Endosome Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Membrane Transport Vesicle Cytoplasmic Vesicle Membrane SNARE Complex Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Neuronal Cell Body Apical Dendrite Basal Dendrite
	Molecular Function	RNA Binding Protein Binding Cadherin Binding	SNAP Receptor Activity Protein Binding Transferase Activity Protein-cysteine S-palmitoyltransferase Activity Cadherin Binding
	Biological Process	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Organization Small GTPase-mediated Signal Transduction Protein Transport Vesicle-mediated Transport Secretory Granule Localization Transcytosis Golgi Vesicle Transport Golgi Vesicle Docking Vesicle Fusion With Golgi Apparatus Membrane Fusion Regulation Of Cellular Response To Insulin Stimulus	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle Targeting Vesicle Docking Involved In Exocytosis Protein Transport Vesicle-mediated Transport Retrograde Transport, Endosome To Golgi Membrane Fusion
Pathways		Golgi Cisternae Pericentriolar Stack Reorganization COPII-mediated vesicle transport COPI-mediated anterograde transport	COPII-mediated vesicle transport COPI-mediated anterograde transport Intra-Golgi traffic RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261) Subjective response to lithium treatment in bipolar disorder ( 26503763)	Birth weight ( 27680694 31043758) Blood sugar levels ( 29403010) Fasting plasma glucose ( 28270201) Hemoglobin A1c levels ( 29403010) HOMA-B (corrected for HOMA-IR) ( 30369944) Liver enzyme levels (alkaline phosphatase) ( 33972514) Offspring birth weight ( 31043758) Pulse pressure ( 27841878) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Type 2 diabetes ( 30054458)
Interacting Genes		33 interacting genes: AKAP9 BET1L BYSL C1orf94 CASP3 CASP8 CSNK2B DUSP12 EEA1 GABPB1 GAK GBF1 GOLGA2 GOLGB1 GOSR1 GOSR2 LENG1 MORF4L1 NSF PHYKPL PLCG1 PRPF6 RAB1A RNF10 RPL9 SCFD1 SF1 SNW1 STX5 STXBP1 UTP14A XPO7 YKT6	3 interacting genes: BET1L HSPA9 USO1
Entrez ID		8615	10652
HPRD ID		09135	16205
Ensembl ID		ENSG00000138768	ENSG00000106636
Uniprot IDs		O60763	A0A7I2V4L6 A4D2J0 O15498
PDB IDs		2W3C	6J74 6J7F 6J7X
Enriched GO Terms of Interacting Partners?		Golgi Vesicle Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cis-Golgi Network Golgi Stack SNAP Receptor Activity Membrane Fusion Intracellular Transport Golgi Membrane SNARE Complex Golgi Organization Golgi Disassembly Golgi Apparatus Cytosolic Transport Vesicle-mediated Transport Cellular Localization Protein Transport Establishment Of Localization In Cell Retrograde Transport, Endosome To Golgi Syntaxin Binding Intracellular Protein Localization Establishment Of Protein Localization SNARE Binding Cytosol Endosomal Transport Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Extrinsic Component Of Postsynaptic Density Membrane Vesicle Organization Intra-Golgi Vesicle-mediated Transport Vesicle Fusion Response To Anesthetic Post-Golgi Vesicle-mediated Transport Organelle Membrane Fusion Death-inducing Signaling Complex Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Positive Regulation Of Pyroptotic Inflammatory Response Organelle Fusion Response To Cobalt Ion Vesicle Docking Membrane Organization Organelle Organization Golgi Cisterna Membrane Death Receptor Binding Regulation Of Golgi Organization Organelle Localization By Membrane Tethering Organelle Disassembly Syntaxin-1 Binding Positive Regulation Of Glycoprotein Metabolic Process Intracellular Protein Transport Membrane Docking Execution Phase Of Apoptosis	Golgi Stack Membrane Organization Golgi Vesicle Docking Membrane Fusion Regulation Of Retrograde Vesicle-mediated Transport, Golgi To ER Protein Transport Negative Regulation Of Hematopoietic Stem Cell Differentiation Cellular Localization Establishment Of Protein Localization MIB Complex Negative Regulation Of Erythrocyte Differentiation SAM Complex Calcium Import Into The Mitochondrion Establishment Of Localization In Cell Intracellular Transport HMG Box Domain Binding Response To Gonadotropin-releasing Hormone CAMP Response Element Binding Vesicle Fusion With Golgi Apparatus Negative Regulation Of Hematopoietic Progenitor Cell Differentiation TIM23 Mitochondrial Import Inner Membrane Translocase Complex Regulation Of Hematopoietic Stem Cell Differentiation Intracellular Protein Localization Mitochondrial Calcium Ion Transmembrane Transport Transcytosis Secretory Granule Localization Iron-sulfur Cluster Assembly Intracellular Protein Transport Negative Regulation Of Stem Cell Differentiation Protein Refolding BHLH Transcription Factor Binding Protein Export From Nucleus Golgi Membrane ATP-dependent Protein Folding Chaperone Inner Mitochondrial Membrane Organization SNAP Receptor Activity
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