DUSP12 and MBD6

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DUSP12	MBD6
Description		dual specificity phosphatase 12	methyl-CpG binding domain protein 6
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Fibrillar Center Nucleus Nucleoplasm Chromosome Chromocenter
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Zinc Ion Binding Hydrolase Activity Phosphatase Activity Kinase Binding Metal Ion Binding	DNA Binding Chromatin Binding Protein Binding
	Biological Process	Dephosphorylation Protein Modification Process
Pathways			UCH proteinases
Drugs
Diseases
GWAS		Albumin-globulin ratio ( 29403010) Immunoglobulin measurement (zinc sulfate turbidity test) ( 29403010) Non-albumin protein levels ( 29403010) Serum alkaline phosphatase levels ( 33547301)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		14 interacting genes: APP CALCOCO2 CCNH CEP126 EIF5 HSPB8 M6PR MBD6 NR1H2 PPP2R3B PTN RABAC1 SRC USO1	4 interacting genes: ATXN1L DUSP12 NCK2 RBM10
Entrez ID		11266	114785
HPRD ID		05323	11296
Ensembl ID		ENSG00000081721	ENSG00000166987
Uniprot IDs		Q9UNI6	Q6P0P0 Q96DN6
PDB IDs		4JNB 4KI9
Enriched GO Terms of Interacting Partners?		Signaling Receptor Activator Activity Negative Regulation Of Long-term Synaptic Potentiation Perinuclear Region Of Cytoplasm Molecular Function Activator Activity Response To Auditory Stimulus Positive Regulation Of Glycolytic Process Integrin Binding Ephrin Receptor Binding Positive Regulation Of Small Molecule Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Catabolic Process Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of ATP Metabolic Process Positive Regulation Of Toll Signaling Pathway Regulation Of Long-term Synaptic Potentiation Dendrite Development Oogenesis Positive Regulation Of Secretion Of Lysosomal Enzymes Golgi Vesicle Docking Acetylcholine Receptor Activator Activity Positive Regulation Of Cellular Component Organization PTB Domain Binding Response To Interleukin-1 Regulation Of ATP Metabolic Process Collateral Sprouting In Absence Of Injury Myeloid Cell Development Regulation Of Protein Import Regulation Of Carbohydrate Catabolic Process Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Small Molecule Metabolic Process Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Endocytosis Transcription Factor TFIIK Complex Cadherin Binding Eukaryotic Initiation Factor EIF2 Binding Female Gamete Generation Dendrite Regeneration Ossification Involved In Bone Remodeling	Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Ribosomal Large Subunit Export From Nucleus Smooth Muscle Cell Apoptotic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Ribosome Biogenesis Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress POZ Domain Binding Regulation Of Ribosome Biogenesis Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Translation In Response To Stress Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Smooth Muscle Cell Proliferation Signal Complex Assembly Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Translation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Hematopoietic Stem Cell Proliferation Regulation Of Cell Population Proliferation Immunological Synapse Formation Dendritic Spine Development Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Hematopoietic Stem Cell Proliferation Positive Regulation Of Smooth Muscle Cell Apoptotic Process Muscle Cell Apoptotic Process Protein Tyrosine/serine/threonine Phosphatase Activity Negative Regulation Of MRNA Splicing, Via Spliceosome 3'-UTR-mediated MRNA Stabilization Cytoskeletal Anchor Activity Regulation Of Translation In Response To Stress Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of RNA Splicing Post-transcriptional Regulation Of Gene Expression MiRNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Smooth Muscle Cell Apoptotic Process Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Biosynthetic Process Signaling Receptor Complex Adaptor Activity Lamellipodium Assembly Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Unfolded Protein Response
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