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NEK8 and ACVR1
Number of citations of the paper that reports this interaction (PMID
15761153
)
154
Data Source:
HPRD
(in vivo)
NEK8
ACVR1
Gene Name
NIMA-related kinase 8
activin A receptor, type I
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasm
Cytoskeleton
Primary Cilium
Ciliary Inversin Compartment
Ciliary Base
Integral Component Of Plasma Membrane
Apical Part Of Cell
Activin Receptor Complex
Molecular Function
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Metal Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Receptor Signaling Protein Serine/threonine Kinase Activity
Transforming Growth Factor Beta Receptor Activity, Type I
Protein Binding
ATP Binding
Activin Receptor Activity, Type I
Peptide Hormone Binding
Protein Homodimerization Activity
SMAD Binding
Metal Ion Binding
Activin Binding
Transforming Growth Factor Beta Binding
Biological Process
Mitotic Cell Cycle
Protein Phosphorylation
Microtubule-based Process
Organ Morphogenesis
Regulation Of Hippo Signaling
G1/S Transition Of Mitotic Cell Cycle
Patterning Of Blood Vessels
Urogenital System Development
In Utero Embryonic Development
Gastrulation With Mouth Forming Second
Mesoderm Formation
Neural Crest Cell Migration
Acute Inflammatory Response
Embryonic Heart Tube Morphogenesis
Mitral Valve Morphogenesis
Atrial Septum Primum Morphogenesis
Protein Phosphorylation
Transforming Growth Factor Beta Receptor Signaling Pathway
Germ Cell Development
Determination Of Left/right Symmetry
Negative Regulation Of Signal Transduction
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Peptidyl-threonine Phosphorylation
Signal Transduction By Phosphorylation
Regulation Of Ossification
Positive Regulation Of Bone Mineralization
BMP Signaling Pathway
Activin Receptor Signaling Pathway
Negative Regulation Of Activin Receptor Signaling Pathway
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Skeletal Muscle Tissue Development
Smooth Muscle Cell Differentiation
Pharyngeal System Development
Pathway-restricted SMAD Protein Phosphorylation
Cardiac Muscle Cell Fate Commitment
Endocardial Cushion Cell Fate Commitment
Cellular Response To Glucocorticoid Stimulus
Positive Regulation Of Determination Of Dorsal Identity
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Adenosine triphosphate
6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine
Diseases
GWAS
Protein-Protein Interactions
6 interactors:
ACVR1
CSN2
TCF4
TGFBR1
TRIM69
UBC
64 interactors:
AP2B1
BAMBI
BMP2
BMP7
BMPR1A
BMPR2
CDK14
CHN1
CREBBP
DCAF6
DUSP13
ENG
FANCL
FBXO30
FCHO1
FGD6
FKBP4
FNTA
GDF5
IGSF1
IKBKB
INHBA
INHBB
INHBC
KLHL35
NEK8
NKIRAS1
NRAS
NUAK2
PAK1
PLEK
PLEKHB1
PLEKHJ1
RAB17
RAB25
RAB33B
RAB3B
RAB6B
RAP2A
RASD2
RASL12
RHEBL1
RHOD
RHOJ
RPS27A
RRAS2
RXRA
SMAD1
SMAD5
SMAD9
SOCS6
STX8
TGFBR1
TGFBR2
THRB
TTC17
TTC27
UBA52
UBE2E3
UBXN1
USP39
VDR
VEPH1
WDR61
Entrez ID
284086
90
HPRD ID
14822
00021
Ensembl ID
ENSG00000115170
Uniprot IDs
Q86SG6
D3DPA4
Q04771
PDB IDs
3H9R
3MTF
3OOM
3Q4U
4BGG
4C02
4DYM
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
Pathway-restricted SMAD Protein Phosphorylation
Pharyngeal System Development
Cellular Response To Transforming Growth Factor Beta Stimulus
Regulation Of Cellular Response To Growth Factor Stimulus
Response To Transforming Growth Factor Beta
Regulation Of Extrinsic Apoptotic Signaling Pathway
Activin Receptor Signaling Pathway
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Stem Cell Development
Negative Regulation Of Apoptotic Signaling Pathway
Signal Transduction By Phosphorylation
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Cell Fate Commitment
Negative Regulation Of Cell Death
Stem Cell Differentiation
Embryonic Organ Morphogenesis
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Cell Cycle Process
Peptidyl-threonine Phosphorylation
Negative Regulation Of Signal Transduction
Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Signaling
Glycogen Metabolic Process
Positive Regulation Of Protein Metabolic Process
Regulation Of Skeletal Muscle Tissue Development
Positive Regulation Of Signal Transduction
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Cell Cycle
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Cell Cycle
Positive Regulation Of Protein Kinase B Signaling
Embryonic Organ Development
Protein Metabolic Process
Gland Development
Polysaccharide Metabolic Process
Muscle Structure Development
Blood Vessel Development
Regulation Of Apoptotic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Vasculature Development
Positive Regulation Of Gene Expression
Regulation Of Cell Death
Cellular Protein Modification Process
Endocardial Cushion Cell Fate Commitment
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Signal Transduction
Cell Communication
Enzyme Linked Receptor Protein Signaling Pathway
Signaling
Cellular Response To Stimulus
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Intracellular Signal Transduction
Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Transforming Growth Factor Beta Receptor Signaling Pathway
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Transforming Growth Factor Beta
Positive Regulation Of Cellular Metabolic Process
Response To Stimulus
BMP Signaling Pathway
Regulation Of Signal Transduction
Positive Regulation Of Protein Modification Process
Cellular Response To Growth Factor Stimulus
Regulation Of Signaling
Response To Growth Factor
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Metabolic Process
Cellular Response To Organic Substance
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Phosphorylation
Small GTPase Mediated Signal Transduction
Regulation Of Cell Differentiation
Regulation Of Cellular Process
Ras Protein Signal Transduction
Anatomical Structure Morphogenesis
Positive Regulation Of Phosphorylation
Positive Regulation Of Transcription, DNA-templated
Cell Surface Receptor Signaling Pathway
Regulation Of Protein Phosphorylation
Regulation Of Intracellular Signal Transduction
Skeletal System Development
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Signal Transduction
Cartilage Development
Positive Regulation Of Macromolecule Biosynthetic Process
Cellular Protein Modification Process
Response To Organic Substance
Positive Regulation Of Gene Expression
Epithelium Development
Positive Regulation Of Cellular Biosynthetic Process
SMAD Protein Signal Transduction
Regulation Of Protein Metabolic Process
Connective Tissue Development
Regulation Of Transcription From RNA Polymerase II Promoter
Cell Differentiation
Tagcloud
?
advances
authors
braf
briefly
changed
counterpart
decades
divide
extremely
focus
gliomas
helped
hggs
highlight
histologic
historically
idh
lethal
ntrk
past
pdgfra
pediatric
phggs
rarity
resection
subgroups
telomeres
tools
v600e
Tagcloud (Difference)
?
advances
authors
braf
briefly
changed
counterpart
decades
divide
extremely
focus
gliomas
helped
hggs
highlight
histologic
historically
idh
lethal
ntrk
past
pdgfra
pediatric
phggs
rarity
resection
subgroups
telomeres
tools
v600e
Tagcloud (Intersection)
?