NEK8 and TRIM69

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NEK8	TRIM69
Description		NIMA related kinase 8	tripartite motif containing 69
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytoskeleton Cilium Cell Projection Ciliary Inversin Compartment Ciliary Base	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Nuclear Speck
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Determination Of Left/right Symmetry Heart Development Animal Organ Morphogenesis Regulation Of Hippo Signaling Animal Organ Development	Apoptotic Process Centrosome Cycle Protein Ubiquitination Innate Immune Response Centrosome Separation Protein Localization To Centrosome
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2)
GWAS		Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 32888494)	Estimated glomerular filtration rate in non-diabetics ( 31451708)
Interacting Genes		11 interacting genes: ACVR1 ADAMTSL4 KRTAP13-2 NEK9 OXER1 RGS20 TCF4 TGFBR1 TRIM42 TRIM69 UBC	55 interacting genes: APP ASNS ATP5MC1 BEX2 BIN3 CDSN DVL1 ETFDH EYA4 FAM110A FAM161A FAM90A1 FKBP1B GEM HAUS1 HGS IYD KLHL38 KRT17 LARP1B LYSMD1 MAGEA4 MAJIN MED20 MID2 NEK8 NTAQ1 PML POLR3K PPP1R18 RECK RINT1 RSPH14 SF1 SF3A3 SKIL SPMIP2 STK3 STK4 STMN3 SYCE2 SYNE4 TNNT2 TRIM44 TRIM54 TRIM55 TRIM63 UBE2D1 UBE2D3 UBE2E1 UBE2H UBE2N WASHC1 WWOX ZNF483
Entrez ID		284086	140691
HPRD ID		14822	11518
Ensembl ID		ENSG00000160602	ENSG00000185880
Uniprot IDs		Q86SG6	H0YL66 Q86WT6
PDB IDs			4NQJ 6YXE
Enriched GO Terms of Interacting Partners?		Activin Receptor Complex Activin Receptor Activity, Type I Transforming Growth Factor Beta Receptor Activity, Type I Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Transmembrane Receptor Protein Serine/threonine Kinase Activity Activin Binding Pharyngeal System Development Transforming Growth Factor Beta Binding Activin Receptor Signaling Pathway Ventricular Septum Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Growth Factor Binding SMAD Binding Endocardial Cushion Cell Fate Commitment Pigment Cell Development 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic Acid Binding 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic Acid Binding 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic Acid Binding Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of SMAD Protein Signal Transduction Cardiac Septum Morphogenesis Positive Regulation Of Determination Of Dorsal Identity Vascular Endothelial Cell Proliferation Epicardium Morphogenesis Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Beta-catenin-TCF7L2 Complex Proepicardium Development Angiogenesis Involved In Coronary Vascular Morphogenesis Transforming Growth Factor Beta Ligand-receptor Complex Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition BMP Receptor Complex TFIIB-class Transcription Factor Binding Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Tight Junction Disassembly Atrial Septum Primum Morphogenesis Endocardial Cushion Fusion Ameboidal-type Cell Migration Protein Kinase Activity Cell Adhesion Involved In Heart Morphogenesis Myofibroblast Differentiation Parathyroid Gland Development Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Regulation Of Extrinsic Apoptotic Signaling Pathway BMP Receptor Activity Cardiac Muscle Cell Fate Commitment Mitral Valve Morphogenesis Positive Regulation Of Mesenchymal Stem Cell Proliferation	Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Ubiquitin Conjugating Enzyme Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Protein K48-linked Ubiquitination Extrinsic Apoptotic Signaling Pathway Primitive Hemopoiesis Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Endocardium Development Regulation Of Protein Polyubiquitination Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activity MRNA 3'-splice Site Recognition Innate Immune Response Protein Binding Regulation Of Apoptotic Signaling Pathway Canonical Wnt Signaling Pathway Protein Modification By Small Protein Conjugation Protein Polyubiquitination Neural Tube Formation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Protein Ubiquitination Regulation Of Hippo Signaling Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Protein Localization To Cytoskeleton Defense Response To Symbiont Defense Response To Other Organism Wnt Signalosome Microtubule Negative Regulation Of Cellular Response To Growth Factor Stimulus Protein Ubiquitination Protein Monoubiquitination Protein Localization To Microtubule Supramolecular Fiber Organization Protein Stabilization
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