NEK8 and TRIM69

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		NEK8	TRIM69
Gene Name		NIMA-related kinase 8	tripartite motif containing 69
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytoskeleton Primary Cilium Ciliary Inversin Compartment Ciliary Base	Nucleus Cytoplasm Plasma Membrane Nuclear Speck
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Ubiquitin-protein Transferase Activity Zinc Ion Binding Ligase Activity
	Biological Process	Mitotic Cell Cycle Protein Phosphorylation Microtubule-based Process Organ Morphogenesis Regulation Of Hippo Signaling	Apoptotic Process Protein Ubiquitination
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: ACVR1 CSN2 TCF4 TGFBR1 TRIM69 UBC	22 interactors: APP ASNS ATP5G1 DVL1 FAM110A FKBP1B HAUS1 IYD KRT17 LARP1B MAGEA4 NEK8 PML PPP1R18 RECK RSPH14 SF1 SF3A3 SKIL SYNE4 TRIM44 ZNF483
Entrez ID		284086	140691
HPRD ID		14822	11518
Ensembl ID			ENSG00000185880
Uniprot IDs		Q86SG6	Q86WT6
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Pathway-restricted SMAD Protein Phosphorylation Pharyngeal System Development Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Response To Transforming Growth Factor Beta Regulation Of Extrinsic Apoptotic Signaling Pathway Activin Receptor Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Stem Cell Development Negative Regulation Of Apoptotic Signaling Pathway Signal Transduction By Phosphorylation Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cell Fate Commitment Negative Regulation Of Cell Death Stem Cell Differentiation Embryonic Organ Morphogenesis Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cell Cycle Process Peptidyl-threonine Phosphorylation Negative Regulation Of Signal Transduction Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Signaling Glycogen Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Signal Transduction Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Cell Cycle Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Cycle Positive Regulation Of Protein Kinase B Signaling Embryonic Organ Development Protein Metabolic Process Gland Development Polysaccharide Metabolic Process Muscle Structure Development Blood Vessel Development Regulation Of Apoptotic Process Positive Regulation Of Macromolecule Biosynthetic Process Vasculature Development Positive Regulation Of Gene Expression Regulation Of Cell Death Cellular Protein Modification Process Endocardial Cushion Cell Fate Commitment	MRNA 3'-splice Site Recognition Collateral Sprouting Maintenance Of Protein Location In Nucleus Anatomical Structure Development System Development Negative Regulation Of Catalytic Activity Protein Localization To Nucleus Regulation Of Cell Development Developmental Process Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Cellular Metabolic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Cell Development Morphogenesis Of An Epithelium MRNA Splice Site Selection Multicellular Organismal Development Organ Development Positive Regulation Of Neuron Projection Development Regulation Of Neuron Differentiation Neuromuscular Junction Development Cellular Nitrogen Compound Metabolic Process Epithelium Development Negative Regulation Of Translation In Response To Oxidative Stress L-asparagine Biosynthetic Process Regulation Of Hormone Levels Anatomical Structure Morphogenesis Positive Regulation Of Cellular Protein Metabolic Process Tissue Development Regulation Of Translation Spliceosomal Complex Assembly Positive Regulation Of Cell Projection Organization Tissue Morphogenesis Positive Regulation Of Cell Cycle Regulation Of Proteolysis Cellular Calcium Ion Homeostasis Positive Regulation Of Proteolysis Cell Differentiation Calcium Ion Homeostasis Regulation Of Neurogenesis Positive Regulation Of Protein Metabolic Process Gene Expression Cellular Component Assembly Regulation Of Calcium Ion Transport Into Cytosol Synaptic Growth At Neuromuscular Junction Positive Regulation Of Sequestering Of Calcium Ion Positive Regulation Of Neuron Differentiation Nitrogen Compound Metabolic Process Response To Light Stimulus Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process
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