NEK8

Gene Name		NIMA-related kinase 8
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytoskeleton Primary Cilium Ciliary Inversin Compartment Ciliary Base
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Mitotic Cell Cycle Protein Phosphorylation Microtubule-based Process Organ Morphogenesis Regulation Of Hippo Signaling
Pathways
Drugs
Diseases
GWAS
Protein-protein Interactions		6 interactors: ACVR1 CSN2 TCF4 TGFBR1 TRIM69 UBC
Entrez ID		284086
HPRD ID		14822
Ensembl ID
Uniprot IDs		Q86SG6
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Pathway-restricted SMAD Protein Phosphorylation Pharyngeal System Development Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Response To Transforming Growth Factor Beta Regulation Of Extrinsic Apoptotic Signaling Pathway Activin Receptor Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Stem Cell Development Negative Regulation Of Apoptotic Signaling Pathway Signal Transduction By Phosphorylation Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cell Fate Commitment Negative Regulation Of Cell Death Stem Cell Differentiation Embryonic Organ Morphogenesis Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cell Cycle Process Peptidyl-threonine Phosphorylation Negative Regulation Of Signal Transduction Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Signaling Glycogen Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Signal Transduction Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Cell Cycle Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Cycle Positive Regulation Of Protein Kinase B Signaling Embryonic Organ Development Protein Metabolic Process Gland Development Polysaccharide Metabolic Process Muscle Structure Development Blood Vessel Development Regulation Of Apoptotic Process Positive Regulation Of Macromolecule Biosynthetic Process Vasculature Development Positive Regulation Of Gene Expression Regulation Of Cell Death Cellular Protein Modification Process Endocardial Cushion Cell Fate Commitment
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