ZBTB1 and AKR7A2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZBTB1	AKR7A2
Description		zinc finger and BTB domain containing 1	aldo-keto reductase family 7 member A2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body Nuclear Membrane	Cytoplasm Mitochondrion Golgi Apparatus Cytosol Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity K63-linked Polyubiquitin Modification-dependent Protein Binding	Aldose Reductase (NADPH) Activity Protein Binding Alcohol Dehydrogenase (NADP+) Activity Electron Transfer Activity Oxidoreductase Activity Phenanthrene-9,10-epoxide Hydrolase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cytokine Production Immune System Process Regulation Of Immune System Process Positive Regulation Of T Cell Mediated Immunity DNA Repair Chromatin Remodeling DNA Damage Response Translesion Synthesis Cell Differentiation B Cell Differentiation Positive Regulation Of Natural Killer Cell Differentiation T Cell Differentiation In Thymus Cellular Response To UV MRNA Transcription By RNA Polymerase II Innate Immune Response Positive Regulation Of T Cell Differentiation Thymus Development Protein Homooligomerization Positive Regulation Of Pro-T Cell Differentiation	Carbohydrate Metabolic Process Aldehyde Metabolic Process Lipid Metabolic Process Daunorubicin Metabolic Process Doxorubicin Metabolic Process
Pathways			Aflatoxin activation and detoxification
Drugs
Diseases
GWAS		Lymphocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494) Urinary albumin-to-creatinine ratio ( 31630189)	Blood protein levels ( 30072576) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Pre-treatment viral load in HIV-1 infection ( 31219150) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995)
Interacting Genes		22 interacting genes: AKR7A2 AR EWSR1 FAM161A FANCG HEMGN KAT5 LZTR1 MAML3 MFAP1 NDN PCNA PIH1D2 PIM1 SCNM1 TRAF1 TRIM42 UBC UBE2I ZBTB25 ZNF417 ZNF572	5 interacting genes: AKR7A3 F2 MCPH1 TRIM63 ZBTB1
Entrez ID		22890	8574
HPRD ID		15688	04567
Ensembl ID		ENSG00000126804	ENSG00000053371
Uniprot IDs		Q9Y2K1	B4DZX4 O43488 V9HWA2
PDB IDs			2BP1
Enriched GO Terms of Interacting Partners?		Nucleoplasm Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Zinc Ion Binding Regulation Of RNA Metabolic Process Transcription Factor Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process
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