CDK10 and RNF115

Number of citations of the paper that reports this interaction (PubMedID 22315970)
45

Data Source:
BioGRID (two hybrid)

		CDK10	RNF115
Description		cyclin dependent kinase 10	ring finger protein 115
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Cytoplasm Cytoskeleton Ciliary Basal Body Cell Projection	Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Cyclin-dependent Protein Kinase Activity Protein Serine Kinase Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Traversing Start Control Point Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Population Proliferation Peptidyl-threonine Phosphorylation Cell Projection Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of MAPK Cascade Negative Regulation Of Cilium Assembly Regulation Of Cell Cycle G2/M Phase Transition	Protein Polyubiquitination Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi To Plasma Membrane Transport Protein Ubiquitination Negative Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Brain morphology (MOSTest) ( 32665545) Brown vs. black hair color ( 30531825) Cutaneous malignant melanoma ( 32341527) Height ( 25429064) Hemoglobin levels ( 32327693) Intake of total sugars ( 31005972) Melanoma ( 28212542) Red vs. brown/black hair color ( 30531825) Waist circumference adjusted for body mass index ( 34021172)	Apolipoprotein A1 levels ( 32203549) Breast cancer ( 25751625 29059683) HDL cholesterol levels ( 32203549) Platelet distribution width ( 32888494)
Interacting Genes		4 interacting genes: CCR4 ETS2 FBXO7 RNF115	34 interacting genes: AKT1 APP ATN1 CDK10 CST3 DAZAP2 DOCK4 EGFR FOLR3 HRAS IGHA1 MAVS MDM2 MDM4 MFAP4 NFKBIA RAB7A RAD23A RPL18A STING1 TTR UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2I UBE2N USP9X VCP ZNRD2
Entrez ID		8558	27246
HPRD ID		04588	18328
Ensembl ID		ENSG00000185324	ENSG00000265491
Uniprot IDs		B7Z537 Q15131	Q9Y4L5
PDB IDs
Enriched GO Terms of Interacting Partners?		Glial Cytoplasmic Inclusion Classical Lewy Body Protein K48-linked Ubiquitination Lewy Body Corona Lewy Neurite Ectodermal Cell Fate Commitment Lewy Body Core Ubiquitin-protein Transferase Activity Protein Polyubiquitination Positive Regulation Of Toll-like Receptor Signaling Pathway	Ubiquitin Conjugating Enzyme Activity Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Polyubiquitination Modification-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Regulation Of Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Protein Modification Process Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Macromolecule Catabolic Process Nucleotide Binding Protein Metabolic Process Protein Monoubiquitination Protein Serine/threonine Kinase Binding Ubiquitin Protein Ligase Binding Positive Regulation Of Cell Cycle G1/S Phase Transition Protein-containing Complex Positive Regulation Of Mitotic Cell Cycle Proteolysis Positive Regulation Of Mitotic Cell Cycle Phase Transition ATP Binding Regulation Of Metabolic Process Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cell Cycle Intracellular Signal Transduction Immune Response-activating Signaling Pathway Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Proteolysis Positive Regulation Of Intracellular Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Enzyme Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cilium Assembly Protein K63-linked Ubiquitination Regulation Of G1/S Transition Of Mitotic Cell Cycle Immune Response-regulating Signaling Pathway Regulation Of Intracellular Signal Transduction Transferase Activity Activation Of Immune Response Protein K6-linked Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Traversing Start Control Point Of Mitotic Cell Cycle
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