LMTK2 and PPM1F

Number of citations of the paper that reports this interaction (PubMedID 28065597)
51

Data Source:
BioGRID (two hybrid)

		LMTK2	PPM1F
Description		lemur tyrosine kinase 2	protein phosphatase, Mg2+/Mn2+ dependent 1F
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Early Endosome Golgi Apparatus Endomembrane System Membrane Growth Cone Neuronal Cell Body Perinuclear Region Of Cytoplasm Recycling Endosome	Nucleus Cytosol Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Phosphatase Inhibitor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Myosin VI Binding Protein Serine Kinase Activity	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Hydrolase Activity Calmodulin-dependent Protein Phosphatase Activity Cation Binding Metal Ion Binding
	Biological Process	Receptor Recycling Protein Phosphorylation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Endocytic Recycling Transferrin Transport Early Endosome To Late Endosome Transport Protein Autophosphorylation	Apoptotic Process Signal Transduction Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Cell Migration Regulation Of Protein Localization Intracellular Signal Transduction Negative Regulation Of DNA-templated Transcription Positive Regulation Of Growth Positive Regulation Of Chemotaxis Negative Regulation Of Protein Transport Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Cellular Response To Xenobiotic Stimulus Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways			Negative regulation of NMDA receptor-mediated neuronal transmission
Drugs
Diseases
GWAS		Gamma glutamyl transferase levels ( 29403010 33339817) Hemoglobin levels ( 32327693) Prostate cancer ( 18264097) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408)	Adventurousness ( 30643258) Attention deficit hyperactivity disorder ( 18839057) Bipolar disorder ( 31043756)
Interacting Genes		24 interacting genes: CDC14A CDC25C CDK5 CDK5R1 DUSP14 DUSP19 DUSP29 DUSP6 ILKAP MTMR6 PPM1A PPM1F PPM1K PPP1CA PPP1CB PPP1CC PPP1R2 PPP3CB PTPDC1 PTPN12 PTPN6 PTPRR STYX TPTE2	21 interacting genes: AATK ARHGEF7 CAMK2A ERBB2 ERBB3 ERBB4 FAM161A FEM1A FEM1B KLHL8 LATS1 LMTK2 MARS1 MEOX1 OGT PAK1 PRKAA1 PTK7 ROR1 ROR2 WEE2-AS1
Entrez ID		22853	9647
HPRD ID		13994	10163
Ensembl ID		ENSG00000164715	ENSG00000100034
Uniprot IDs		Q8IWU2	B5MCT7 P49593
PDB IDs
Enriched GO Terms of Interacting Partners?		Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Dephosphorylation Protein Tyrosine Phosphatase Activity Dephosphorylation Hydrolase Activity Cation Binding Phosphate-containing Compound Metabolic Process Protein Tyrosine/serine/threonine Phosphatase Activity Calmodulin-dependent Protein Phosphatase Activity Phosphatase Activity PTW/PP1 Phosphatase Complex Protein Modification Process Glycogen Metabolic Process Cytoplasm Negative Regulation Of MAPK Cascade Peptidyl-tyrosine Dephosphorylation Energy Reserve Metabolic Process Polysaccharide Metabolic Process Entrainment Of Circadian Clock By Photoperiod Protein Kinase 5 Complex Photoperiodism Entrainment Of Circadian Clock Cytosol MAPK Cascade Rhythmic Process Cell Division Protein Kinase Binding Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Circadian Regulation Of Gene Expression Energy Derivation By Oxidation Of Organic Compounds Non-membrane Spanning Protein Tyrosine Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Negative Regulation Of ERK1 And ERK2 Cascade Nucleoplasm Protein Metabolic Process Regulation Of MAPK Cascade Transmembrane Receptor Protein Tyrosine Phosphatase Activity Layer Formation In Cerebral Cortex Negative Regulation Of Intracellular Signal Transduction Regulation Of Circadian Rhythm Protein Phosphatase 1 Binding Positive Regulation Of Protein Targeting To Membrane Regulation Of Nucleocytoplasmic Transport Regulation Of Cellular Localization Negative Regulation Of Signaling Regulation Of Establishment Of Protein Localization	Protein Kinase Activity Kinase Activity ATP Binding Nucleotide Binding Transferase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Coreceptor Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway ERBB3:ERBB2 Complex Wound Healing ERBB2 Signaling Pathway Protein Serine Kinase Activity Receptor Complex Neuregulin Receptor Activity Positive Regulation Of Signal Transduction Protein Serine/threonine Kinase Activity Protein Modification Process Enzyme-linked Receptor Protein Signaling Pathway ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cellular Response To Epidermal Growth Factor Stimulus Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Signal Transduction Response To Epidermal Growth Factor Regulation Of Catalytic Activity Protein Phosphorylation Cell Surface Receptor Signaling Pathway ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Mesenchyme Development Epidermal Growth Factor Receptor Signaling Pathway Apoptotic Process Glial Cell Development Regulation Of Protein Localization Basal Plasma Membrane Phosphorylation Cell Death Programmed Cell Death Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Regulation Of Insulin Receptor Signaling Pathway Axon Response To Wounding ERBB Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Fibroblast Migration Regulation Of Organ Growth
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