LMTK2 and CDK5R1

Number of citations of the paper that reports this interaction (PMID 12832520)
10

Data Source:
HPRD (two hybrid, in vitro)

		LMTK2	CDK5R1
Gene Name		lemur tyrosine kinase 2	cyclin-dependent kinase 5, regulatory subunit 1 (p35)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Early Endosome Golgi Apparatus Integral Component Of Membrane Perinuclear Region Of Cytoplasm Recycling Endosome	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Membrane Cyclin-dependent Protein Kinase 5 Holoenzyme Complex Axon Dendrite Growth Cone Neuromuscular Junction Neuronal Cell Body Dendritic Spine Intracellular Membrane-bounded Organelle Contractile Fiber Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Phosphatase Inhibitor Activity Protein Binding ATP Binding Myosin VI Binding	Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Calcium Ion Binding Protein Binding Kinase Activity Cyclin-dependent Protein Kinase 5 Activator Activity Protein Kinase Binding Protein Serine/threonine Kinase Activator Activity Cadherin Binding Ephrin Receptor Binding
	Biological Process	Receptor Recycling Protein Phosphorylation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Endocytic Recycling Transferrin Transport Negative Regulation Of Catalytic Activity Early Endosome To Late Endosome Transport Protein Autophosphorylation	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Neuron Migration Neuron Cell-cell Adhesion G-protein Coupled Acetylcholine Receptor Signaling Pathway Axon Guidance Axonal Fasciculation Brain Development Cell Proliferation Embryo Development Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cerebellum Development Superior Olivary Nucleus Maturation Hippocampus Development Layer Formation In Cerebral Cortex Neuron Differentiation Negative Regulation Of Axon Extension Neuron Projection Development Regulation Of Actin Cytoskeleton Organization Serine Phosphorylation Of STAT3 Protein Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Negative Regulation Of Transcription, DNA-templated Ephrin Receptor Signaling Pathway Rhythmic Process Regulation Of Dendritic Spine Morphogenesis Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Targeting To Membrane
Pathways			Axon guidance Semaphorin interactions CRMPs in Sema3A signaling
Drugs
Diseases
GWAS		Prostate cancer ( 18264097)
Protein-Protein Interactions		5 interactors: CDK5 CDK5R1 PPP1CA PPP1CC PPP1R2	31 interactors: ACTN1 AMPH APP BLOC1S6 CAMK2A CAPN1 CAPN2 CDK16 CDK5 CDK5RAP1 CDK5RAP2 CDK5RAP3 CDK9 CHN1 CTNNB1 HSP90AA1 KRT40 KRTAP10-3 LMTK2 MAPT MTUS2 NEDD4 NES NOTCH2NL ODF1 PAK1 SET SIAH1 STXBP1 TSC22D4 TTBK1
Entrez ID		22853	8851
HPRD ID		13994	04586
Ensembl ID		ENSG00000164715	ENSG00000176749
Uniprot IDs		Q8IWU2	Q15078 Q8N619
PDB IDs			1H4L 1UNG 1UNH 1UNL 3O0G
Enriched GO Terms of Interacting Partners?		Rhythmic Process Glycogen Metabolic Process Serine Phosphorylation Of STAT3 Protein Polysaccharide Metabolic Process Serine Phosphorylation Of STAT Protein Energy Reserve Metabolic Process Triglyceride Catabolic Process Entrainment Of Circadian Clock By Photoperiod Cellular Carbohydrate Metabolic Process Negative Regulation Of Axon Extension Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process Positive Regulation Of Protein Targeting To Membrane Regulation Of Dendritic Spine Morphogenesis Energy Derivation By Oxidation Of Organic Compounds Regulation Of Signal Transduction Response To Light Stimulus Layer Formation In Cerebral Cortex Cerebral Cortex Radial Glia Guided Migration Peptidyl-threonine Phosphorylation Regulation Of Signaling Regulation Of Dendritic Spine Development Generation Of Precursor Metabolites And Energy Cell Division Positive Regulation Of Neuron Apoptotic Process Response To Radiation Cerebral Cortex Radially Oriented Cell Migration Negative Regulation Of Axonogenesis Glial Cell Migration Regulation Of Axon Extension Regulation Of Dendrite Morphogenesis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Hippocampus Development Positive Regulation Of Neuron Death Circadian Regulation Of Gene Expression Negative Regulation Of Developmental Growth Cerebral Cortex Cell Migration Regulation Of JAK-STAT Cascade Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Triglyceride Metabolic Process Regulation Of Circadian Rhythm Response To External Stimulus Limbic System Development Regulation Of Cell Cycle Arrest Positive Regulation Of Cell Death Negative Regulation Of Cell Morphogenesis Involved In Differentiation Telencephalon Cell Migration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway	Generation Of Neurons Nervous System Development Neurogenesis Establishment Of Localization In Cell Neuron Projection Development Cellular Localization Neuron Differentiation Cell Differentiation Cell Projection Organization Neuron Development Multicellular Organismal Development Vesicle-mediated Transport Regulation Of Organelle Organization Regulation Of Neurogenesis Establishment Of Organelle Localization Regulation Of Cellular Component Organization Developmental Process Cell Morphogenesis Involved In Differentiation Exocytosis Axonogenesis Synaptic Vesicle Transport Regulation Of Neuron Differentiation Cell Morphogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Cell Projection Morphogenesis Cell Development Regulation Of Cell Development System Development Cell Part Morphogenesis Organelle Localization Neuron Projection Morphogenesis Receptor Catabolic Process Anatomical Structure Development Synapse Organization Regulation Of Cytoskeleton Organization Secretion By Cell Brain Development Receptor Metabolic Process Response To Abiotic Stimulus Head Development Establishment Of Vesicle Localization Negative Regulation Of Neuron Death Vesicle Localization Axon Guidance Regulation Of Cell Differentiation Secretion Anatomical Structure Morphogenesis Regulation Of Cell Cycle Locomotion
Tagcloud ?			10a 200c 30a 30c arhgap5 cd36 cdh2 chips cyp27b1 figure gemcitabine gna13 gp5 hist1h2bf hlf igsf3 ikbkb il32 intriguing mirs nrp2 oxidoreductase pak7 putatively rab23 rap2a slc11a1 sod3 tp53i3
Tagcloud (Difference) ?			10a 200c 30a 30c arhgap5 cd36 cdh2 chips cyp27b1 figure gemcitabine gna13 gp5 hist1h2bf hlf igsf3 ikbkb il32 intriguing mirs nrp2 oxidoreductase pak7 putatively rab23 rap2a slc11a1 sod3 tp53i3
Tagcloud (Intersection) ?