MBD3L1 and MBD2

Number of citations of the paper that reports this interaction (PMID 15456747)
18

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		MBD3L1	MBD2
Gene Name		methyl-CpG binding domain protein 3-like 1	methyl-CpG binding domain protein 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Plasma Membrane	Histone Deacetylase Complex Nuclear Chromatin Heterochromatin Nucleus Nucleoplasm Cytoplasm Protein Complex
	Molecular Function		RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Satellite DNA Binding MRNA Binding Protein Binding Methyl-CpG Binding Protein Domain Specific Binding Nucleosomal DNA Binding SiRNA Binding C2H2 Zinc Finger Domain Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Gene Expression Positive Regulation Of Wnt Signaling Pathway Regulation Of Gene Expression, Epigenetic Regulation Of Cell Proliferation Maternal Behavior ATP-dependent Chromatin Remodeling Cellular Protein Complex Assembly Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated
Pathways			NoRC negatively regulates rRNA expression RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription RNA Polymerase I Promoter Clearance Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression RNA Polymerase I Promoter Opening
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: MBD2 MBD3	14 interactors: CREBBP DHX9 GATAD2A GATAD2B GPN1 HDAC1 HDAC2 HINFP LAMTOR3 MBD3 MBD3L1 MBD3L2 RBBP4 SIN3A
Entrez ID		85509	8932
HPRD ID		12138	04647
Ensembl ID		ENSG00000170948	ENSG00000134046
Uniprot IDs		Q8WWY6	Q9UBB5
PDB IDs			2L2L
Enriched GO Terms of Interacting Partners?		ATP-dependent Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic Chromatin Remodeling Regulation Of Gene Expression, Epigenetic Methylation-dependent Chromatin Silencing Chromatin Modification Chromatin Organization Negative Regulation Of Transcription From RNA Polymerase II Promoter Maternal Behavior Chromosome Organization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Silencing Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Gene Silencing Histone Acetylation Transcription, DNA-templated Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation RNA Biosynthetic Process Protein Acetylation Positive Regulation Of Wnt Signaling Pathway Organelle Organization RNA Metabolic Process Peptidyl-lysine Modification Gene Expression	ATP-dependent Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Chromatin Modification Chromosome Organization Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Chromatin Organization Chromatin Remodeling Gene Expression Negative Regulation Of Gene Expression Rhythmic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Embryo Development Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Histone Modification Macromolecule Biosynthetic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Histone Deacetylation Cellular Response To Heat Protein Deacetylation Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Embryonic Digit Morphogenesis Fungiform Papilla Formation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Fungiform Papilla Morphogenesis Positive Regulation Of Receptor Biosynthetic Process Fungiform Papilla Development Eyelid Development In Camera-type Eye Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Hair Follicle Placode Formation Response To Heat Tongue Morphogenesis Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Receptor Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Histone H4 Deacetylation
Tagcloud ?		15q11 biallelically bipartite brdt centre eg hitherto imprinted imprinting mbd1 mbd2 meiosis meiotic mined overlaps paternally pwrn1 pwrn2 q13 reprogramming snrpn snurf spermatogenesis spermatogenic suvh39h2 testicular testis undetected upstream	additionally adipose closely cpg deacetylases detailed dio dnmts epigenetic fatty feedback h3k4 h4 hdacs histones hypoacetylated hypomethylated island leptin maintain methyltransferases modification modifications obese obesity pol polyunsaturated pufas serve
Tagcloud (Difference) ?		15q11 biallelically bipartite brdt centre eg hitherto imprinted imprinting mbd1 meiosis meiotic mined overlaps paternally pwrn1 pwrn2 q13 reprogramming snrpn snurf spermatogenesis spermatogenic suvh39h2 testicular testis undetected upstream	additionally adipose closely cpg deacetylases detailed dio dnmts epigenetic fatty feedback h3k4 h4 hdacs histones hypoacetylated hypomethylated island leptin maintain methyltransferases modification modifications obese obesity pol polyunsaturated pufas serve
Tagcloud (Intersection) ?		mbd2