DIXDC1 and ZDHHC17

Number of citations of the paper that reports this interaction (PubMedID 24705354)
111

Data Source:
BioGRID (two hybrid)

		DIXDC1	ZDHHC17
Description		DIX domain containing 1	zDHHC palmitoyltransferase 17
Image
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Cytosol Cytoskeleton Focal Adhesion Anchoring Junction Postsynapse Glutamatergic Synapse	Golgi Membrane Golgi Apparatus Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Golgi-associated Vesicle Membrane Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Synapse Glutamatergic Synapse Perforant Pathway To Dendrate Granule Cell Synapse Postsynaptic Golgi Apparatus
	Molecular Function	Actin Binding Protein Binding Protein Domain Specific Binding Gamma-tubulin Binding	Signaling Receptor Binding Protein Binding Palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity Identical Protein Binding Protein-cysteine S-stearoyltransferase Activity
	Biological Process	Wnt Signaling Pathway Cerebral Cortex Cell Migration Cerebral Cortex Radially Oriented Cell Migration Cell Proliferation In Forebrain Forebrain Ventricular Zone Progenitor Cell Division Positive Regulation Of Wnt Signaling Pathway Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Neuron Differentiation Canonical Wnt Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Modification Of Postsynaptic Actin Cytoskeleton	Axonogenesis Protein Palmitoylation Lipoprotein Transport Regulation Of Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission
Pathways
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Smoking initiation ( 33082346) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Mean arterial pressure x educational attainment (some college) interaction (2df) ( 32372009) Metabolite levels ( 23823483) Visceral fat ( 30942860)
Interacting Genes		8 interacting genes: APP ATXN1 AXIN1 CDC5L MAP3K4 NDEL1 ULK2 ZDHHC17	192 interacting genes: ABCG4 ACTR1B ADD1 AHDC1 AIDA AK3 ALKBH3 ANKRD50 ANXA11 APBB1IP ARFGAP3 ASF1A ASIC4 BCAS3 BEX2 BTF3 C1orf216 C20orf141 CBS CCDC120 CCDC7 CCNE2 CDSN CENPBD2P CHMP1A CIB1 CLRN3 CNDP2 CNKSR1 COG3 CSTA CTCFL CTHRC1 DALRD3 DELE1 DIXDC1 DLG4 DLK1 DR1 DTX3 E2F8 EDRF1 EEF1G ERCC6L EVL EXOSC9 EYA3 FAM9A FBH1 FOXD4L6 FTL FUT2 FUT9 GABPB1 GABPB2 GATA1 GOLPH3L GPR135 GRB10 GUSBP3 H2AP H2BC9 H3C10 HBG1 HECTD3 HLA-A HLA-DRB1 HMBS HOXA3 HS1BP3 HTT IFT20 IFT57 INPP5D JMJD7-PLA2G4B KHDC4 KIAA0408 KNSTRN KRAS KRT17 KRT8P12 KRTAP11-1 KRTAP9-2 LCA5L LCMT1P1 LGALS9C LIN28A LMAN2L LNCRI LRRC45 LY6G6C MANF MAP2K4 MAP3K19 MIIP MLH3 MRFAP1 MRFAP1L1 MSANTD3 MSRB2 MYBPHL MYOZ2 NCBP1 NEBL NFATC2IP NFYC NIFK NPFF ODF2 OFCC1 OTUD7B OTX2 PABIR3 PBRM1 PDZK1IP1 PHF5A PLEKHB1 PPP1R21 PPTC7 PRMT5 PTMA QRICH1 RAB39B RAD51 RANGRF RAP1B RBM5 RCAN3 RIC8A RNF20 RNF38 RSBN1L RUBCNL SCNM1 SEMA4G SF3A3 SHOX2 SKA3 SLC1A3 SLC25A31 SLC9A9 SLX9 SMARCB1 SNAP25 SOX14 SP2 SPRY3 SPRY4 SREBF2 SRSF4 STK25 STN1 SUMF2 SYT1 TEAD1 THAP7 TIGD1 TMC6 TMCC1 TMEM115 TMEM186 TMTC1 TNFAIP1 TNFSF10 TOX TPGS2 TTC23 TTLL7 TUT7 TXNDC12 TXNDC15 UBAC1 UBE2K USP18 USP32 VN1R10P VSX2 WAC WDR20 YIF1A YTHDF3 ZCCHC17 ZFC3H1 ZFP2 ZFP36 ZFYVE19 ZNF333 ZNF341 ZNF597 ZNF624 ZNF667-AS1 ZSCAN9
Entrez ID		85458	23390
HPRD ID		16804	09697
Ensembl ID		ENSG00000150764	ENSG00000186908
Uniprot IDs		Q155Q3	A8KA01 Q8IUH5
PDB IDs		3PZ7	3EU9 5W7I 5W7J
Enriched GO Terms of Interacting Partners?		Axonogenesis Cell Projection Morphogenesis Neuron Projection Morphogenesis Collateral Sprouting Developmental Cell Growth Developmental Growth Involved In Morphogenesis Identical Protein Binding Protein Serine/threonine Kinase Binding Regulation Of MAPK Cascade Anatomical Structure Morphogenesis Amyloid-beta Complex Growth Cone Lamellipodium Response To Light Stimulus Visual Behavior Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Visual Learning Cytoplasmic Vesicle Signal Transduction Beta-catenin Destruction Complex Assembly Somatic Sensory System Development Perforant Pathway To Dendrate Granule Cell Synapse Developmental Growth Adult Locomotory Behavior Axo-dendritic Transport Acetylcholine Receptor Activator Activity Associative Learning Positive Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade Lipoprotein Particle Cell Projection Organization Positive Regulation Of Protein Import Response To Radiation Male Germ-line Sex Determination Axial Mesoderm Formation Neuron Projection Extension Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Neurofilament Cytoskeleton PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Intracellular Transport Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Positive Regulation Of Intracellular Signal Transduction Memory Developmental Process	Protein Binding
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