APOL1 and APOA1

Number of citations of the paper that reports this interaction (PMID 9325276)
27

Data Source:
HPRD (in vivo)

		APOL1	APOA1
Gene Name		apolipoprotein L, 1	apolipoprotein A-I
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Intrinsic Component Of Membrane Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Blood Microparticle	Extracellular Region Extracellular Space Nucleus Early Endosome Endoplasmic Reticulum Lumen Cytosol Plasma Membrane Cell Surface Endocytic Vesicle Cytoplasmic Vesicle Vesicle Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Discoidal High-density Lipoprotein Particle Spherical High-density Lipoprotein Particle Secretory Granule Lumen Chylomicron Extracellular Vesicular Exosome Endocytic Vesicle Lumen Blood Microparticle
	Molecular Function	Chloride Channel Activity Protein Binding Lipid Binding	Beta-amyloid Binding Protein Binding Phospholipid Binding Phospholipid Transporter Activity High-density Lipoprotein Particle Binding Cholesterol Binding Cholesterol Transporter Activity Enzyme Binding Phosphatidylcholine Binding Apolipoprotein Receptor Binding Apolipoprotein A-I Receptor Binding Identical Protein Binding Chemorepellent Activity Lipase Inhibitor Activity Phosphatidylcholine-sterol O-acyltransferase Activator Activity High-density Lipoprotein Particle Receptor Binding
	Biological Process	Chloride Transport Lipid Transport Receptor-mediated Endocytosis Cholesterol Metabolic Process Cytolysis Killing Of Cells Of Other Organism Lipoprotein Metabolic Process Innate Immune Response Chloride Transmembrane Transport	Retinoid Metabolic Process Regulation Of Protein Phosphorylation Endothelial Cell Proliferation Platelet Degranulation Negative Regulation Of Cytokine Secretion Involved In Immune Response Phosphatidylcholine Biosynthetic Process Cholesterol Biosynthetic Process Receptor-mediated Endocytosis Transforming Growth Factor Beta Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Response To Nutrient Blood Coagulation Phototransduction, Visible Light Cholesterol Metabolic Process Glucocorticoid Metabolic Process Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cholesterol Esterification Positive Regulation Of Triglyceride Catabolic Process Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Peripheral Nervous System Axon Regeneration Protein Oxidation Peptidyl-methionine Modification Lipid Storage Platelet Activation Regulation Of Intestinal Cholesterol Absorption Cholesterol Transport Adrenal Gland Development Organ Regeneration Neuron Projection Regeneration Regulation Of Cdc42 Protein Signal Transduction Cholesterol Efflux Phospholipid Efflux Negative Regulation Of Heterotypic Cell-cell Adhesion High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Assembly High-density Lipoprotein Particle Clearance Positive Regulation Of Rho Protein Signal Transduction Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Response To Drug Cholesterol Homeostasis Blood Vessel Endothelial Cell Migration Response To Estrogen Reverse Cholesterol Transport Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Interleukin-1 Beta Secretion Negative Regulation Of Inflammatory Response Protein Stabilization Negative Chemotaxis Positive Regulation Of Lipoprotein Lipase Activity Positive Regulation Of Hydrolase Activity Positive Regulation Of Transferase Activity Positive Regulation Of Stress Fiber Assembly Transmembrane Transport Phospholipid Homeostasis Negative Regulation Of Lipase Activity Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Response To Cytokine Stimulus Triglyceride Homeostasis ERK1 And ERK2 Cascade Cholesterol Import Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		Scavenging of heme from plasma	Lipoprotein metabolism PPARA activates gene expression Metabolism of lipids and lipoproteins ABC-family proteins mediated transport Chylomicron-mediated lipid transport Platelet degranulation Amyloids Response to elevated platelet cytosolic Ca2+ Scavenging by Class A Receptors Retinoid metabolism and transport Fatty acid, triacylglycerol, and ketone body metabolism Lipid digestion, mobilization, and transport Diseases associated with visual transduction HDL-mediated lipid transport Scavenging of heme from plasma Visual phototransduction Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Platelet activation, signaling and aggregation Scavenging by Class B Receptors ABCA transporters in lipid homeostasis
Drugs
Diseases
GWAS		Glomerulosclerosis ( 20668430)	Cholesterol, total ( 19060911 20686565) Coronary heart disease ( 21378990) HDL cholesterol ( 20864672 19060906 20686565) Hematological and biochemical traits ( 20139978) Hypertriglyceridemia ( 23505323) LDL cholesterol ( 18179892 20864672 19060911 20686565) Lipid metabolism phenotypes ( 22286219) Metabolite levels ( 22916037) Triglycerides ( 19074352 21909109 18193043 18193044 18193046 20864672 19060906 19060911 20139978 20686565)
Protein-Protein Interactions		2 interactors: APOA1 CDC23	35 interactors: ABCA1 ABCA13 AKT2 APOA1BP APOA2 APOB APOC1 APOF APOL1 APP ATP5B CETP CFHR1 CLEC4G CMTM5 FBLN1 GPLD1 HPR JAK3 LBP LCAT MAP7D1 MAPK6 PCMT1 PDE1A PLTP PON1 SAA2 SCARB1 SPP1 TNFRSF10C TOMM20 TTR VKORC1 ZNRD1
Entrez ID		8542	335
HPRD ID		04774	02517
Ensembl ID		ENSG00000100342	ENSG00000118137
Uniprot IDs		B1AH95 O14791 Q2KHQ6	P02647
PDB IDs			1AV1 1GW3 1GW4 1ODP 1ODQ 1ODR 2A01 3J00 3K2S 3R2P
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Interleukin-1 Beta Secretion Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Cholesterol Import Negative Regulation Of Interleukin-1 Secretion High-density Lipoprotein Particle Clearance Protein Oxidation Positive Regulation Of Transferase Activity Negative Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Cytokine Secretion Involved In Immune Response High-density Lipoprotein Particle Assembly Metaphase/anaphase Transition Of Mitotic Cell Cycle Positive Regulation Of Triglyceride Catabolic Process Positive Regulation Of Cholesterol Esterification Regulation Of Intestinal Cholesterol Absorption Phospholipid Homeostasis Peptidyl-methionine Modification Regulation Of Cholesterol Esterification Peripheral Nervous System Axon Regeneration Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Exit From Mitosis Phospholipid Efflux Regulation Of Cytokine Secretion Involved In Immune Response Negative Regulation Of Catalytic Activity Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Lipoprotein Lipase Activity Negative Regulation Of Interleukin-1 Beta Production Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway High-density Lipoprotein Particle Remodeling Glucocorticoid Metabolic Process Protein-lipid Complex Assembly Endothelial Cell Proliferation Reverse Cholesterol Transport Regulation Of Organelle Organization Negative Chemotaxis Negative Regulation Of Lipase Activity Protein K11-linked Ubiquitination Regulation Of Interleukin-1 Beta Secretion Phosphatidylcholine Biosynthetic Process Positive Regulation Of Lipid Catabolic Process Plasma Lipoprotein Particle Remodeling Positive Regulation Of Steroid Metabolic Process Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Mitotic Metaphase Plate Congression Cholesterol Efflux Regulation Of Cdc42 Protein Signal Transduction Positive Regulation Of Fatty Acid Metabolic Process Metaphase Plate Congression Blood Vessel Endothelial Cell Migration Regulation Of Substrate Adhesion-dependent Cell Spreading	Cholesterol Metabolic Process Alcohol Metabolic Process Sterol Metabolic Process Cholesterol Transport Sterol Transport Lipid Transport Lipid Localization Steroid Metabolic Process Cholesterol Efflux Plasma Lipoprotein Particle Remodeling Regulation Of Plasma Lipoprotein Particle Levels Reverse Cholesterol Transport High-density Lipoprotein Particle Remodeling Small Molecule Metabolic Process Lipid Metabolic Process Lipoprotein Metabolic Process Cholesterol Homeostasis Sterol Homeostasis Regulation Of Cholesterol Transport Regulation Of Lipid Transport Protein-lipid Complex Assembly Lipid Homeostasis Phosphatidylcholine Metabolic Process Regulation Of Lipid Catabolic Process Glycerolipid Metabolic Process Plasma Lipoprotein Particle Clearance Phospholipid Transport Triglyceride Metabolic Process Neutral Lipid Metabolic Process Triglyceride-rich Lipoprotein Particle Remodeling Cellular Lipid Metabolic Process Phospholipid Efflux Low-density Lipoprotein Particle Remodeling Cellular Biogenic Amine Metabolic Process Transport Amine Metabolic Process Lipopolysaccharide Transport Endocytosis Regulation Of Lipid Metabolic Process Regulation Of Cholesterol Efflux Negative Regulation Of Lipid Transport Negative Regulation Of Lipid Catabolic Process Locomotion Regulation Of Phosphatidylcholine Catabolic Process Response To Lipid Chemical Homeostasis High-density Lipoprotein Particle Clearance Cell Motility Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Lipid Biosynthetic Process
Tagcloud ?		advance americans apolipoprotein august collapsing doi elevate glomerulosclerosis hairpin identifies illustrates inducers injurious interferon interferons irf1 irf2 irf3 online polyi publication relied segmental stat2 tbk1 tlr tlr3 toll upregulating	admission atherosclerosis believed concentration consequence controls explain explanation explicable fifth genotypes hdl immediately infarction mi microg min ml myocardial nmol occured paraoxonase pon1 reside risen subfraction subgroups thrombolytic variation
Tagcloud (Difference) ?		advance americans apolipoprotein august collapsing doi elevate glomerulosclerosis hairpin identifies illustrates inducers injurious interferon interferons irf1 irf2 irf3 online polyi publication relied segmental stat2 tbk1 tlr tlr3 toll upregulating	admission atherosclerosis believed concentration consequence controls explain explanation explicable fifth genotypes hdl immediately infarction mi microg min ml myocardial nmol occured paraoxonase pon1 reside risen subfraction subgroups thrombolytic variation
Tagcloud (Intersection) ?