APOL1 and CACNA1I

		APOL1	CACNA1I
Description		apolipoprotein L1	calcium voltage-gated channel subunit alpha1 I
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Membrane Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Blood Microparticle	Plasma Membrane Voltage-gated Calcium Channel Complex Membrane Monoatomic Ion Channel Complex
	Molecular Function	Chloride Channel Activity Protein Binding Lipid Binding	Monoatomic Ion Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity
	Biological Process	Lipid Metabolic Process Lipid Transport Steroid Metabolic Process Cholesterol Metabolic Process Lipoprotein Metabolic Process Innate Immune Response Cytolysis By Host Of Symbiont Cells Chloride Transmembrane Transport	Monoatomic Ion Transport Calcium Ion Transport Signal Transduction Neuronal Action Potential Sleep Monoatomic Ion Transmembrane Transport Transmembrane Transport Calcium Ion Transmembrane Transport Calcium Ion Import Across Plasma Membrane
Pathways		Scavenging of heme from plasma Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	NCAM1 interactions Smooth Muscle Contraction
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Ergocalciferol Enflurane Amlodipine Spironolactone Cinnarizine Paramethadione Nicardipine Nicardipine Verapamil Zonisamide Nifedipine Amiodarone Mibefradil Flunarizine Nylidrin Nilvadipine Nilvadipine Cannabidiol Trimebutine Benidipine Efonidipine Efonidipine Efonidipine Manidipine Manidipine Butamben Bioallethrin Bioallethrin Medical Cannabis Nabiximols
Diseases
GWAS		Blood protein levels ( 30072576) Diabetic kidney disease ( 26305897) End-stage kidney disease ( 31178898) End-stage renal disease ( 29885931) Glomerulosclerosis ( 20668430)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Hodgkin's lymphoma ( 34216518) Household income (MTAG) ( 31844048) IgG glycosylation ( 23382691) Intelligence (MTAG) ( 29326435) Negative urgency ( 30718321) Refractive error ( 32231278) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Schizophrenia ( 22883433 28991256 29483656 30285260)
Interacting Genes		2 interacting genes: APOA1 CDC23
Entrez ID		8542	8911
HPRD ID		04774	10500
Ensembl ID		ENSG00000100342	ENSG00000100346
Uniprot IDs		B1AH95 O14791 Q2KHQ6	Q9P0X4
PDB IDs		7L6K 7LF7 7LFA 7LFB 7LFD	7WLI 7WLJ 7WLK 7WLL
Enriched GO Terms of Interacting Partners?		Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Organelle Organization Positive Regulation Of Interleukin-17-mediated Signaling Pathway Actin Ubiquitination Positive Regulation Of Chemokine (C-C Motif) Ligand 20 Production Positive Regulation Of Cellular Component Organization Apolipoprotein A-I Receptor Binding Peptidyl-methionine Modification Phosphatidylcholine-sterol O-acyltransferase Activator Activity Regulation Of Intestinal Cholesterol Absorption Lipoprotein Biosynthetic Process Protein Oxidation Cholesterol Import High-density Lipoprotein Particle Receptor Binding Positive Regulation Of Phospholipid Efflux Regulation Of Organelle Organization Apolipoprotein Receptor Binding Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Regulation Of Cytokine-mediated Signaling Pathway High-density Lipoprotein Particle Clearance Protein Polyubiquitination Metaphase/anaphase Transition Of Mitotic Cell Cycle Ubiquitin-protein Transferase Activity Sleep Protein Localization To Phagocytic Vesicle Actin Modification Striated Muscle Myosin Thick Filament Free Ubiquitin Chain Polymerization Cytosolic Ciliogenesis Spherical High-density Lipoprotein Particle Lipoprotein Particle Binding Metaphase/anaphase Transition Of Cell Cycle Negative Regulation Of Cell Adhesion Molecule Production Amyloid-beta Formation High-density Lipoprotein Particle Assembly Regulation Of Intestinal Lipid Absorption Positive Regulation Of Cell Cycle Tat Protein Binding Negative Regulation Of Heterotypic Cell-cell Adhesion High-density Lipoprotein Particle Binding Regulation Of Cell Adhesion Molecule Production Protein Modification Process Chylomicron Phospholipid Efflux Regulation Of Cdc42 Protein Signal Transduction Regulation Of Intestinal Absorption Positive Regulation Of Phospholipid Transport Glucocorticoid Metabolic Process High Voltage-gated Calcium Channel Activity High-density Lipoprotein Particle
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