ALG2 and PTPN23

Number of citations of the paper that reports this interaction (PMID 17174262)
10

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		ALG2	PTPN23
Gene Name		ALG2, alpha-1,3/1,6-mannosyltransferase	protein tyrosine phosphatase, non-receptor type 23
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Cytoplasmic Membrane-bounded Vesicle Ciliary Basal Body Extracellular Vesicular Exosome
	Molecular Function	Alpha-1,3-mannosyltransferase Activity GDP-Man:Man1GlcNAc2-PP-Dol Alpha-1,3-mannosyltransferase Activity Protein Binding Glycolipid 6-alpha-mannosyltransferase Activity Protein Heterodimerization Activity Protein N-terminus Binding Calcium-dependent Protein Binding	Protein Tyrosine Phosphatase Activity Protein Binding Protein Kinase Binding
	Biological Process	Dolichol-linked Oligosaccharide Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Protein Glycosylation In Endoplasmic Reticulum Post-translational Protein Modification Cellular Protein Metabolic Process Response To Calcium Ion Mannosylation	Negative Regulation Of Epithelial Cell Migration Protein Transport Peptidyl-tyrosine Dephosphorylation Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Cilium Morphogenesis Positive Regulation Of Homophilic Cell Adhesion Positive Regulation Of Adherens Junction Organization Positive Regulation Of Early Endosome To Late Endosome Transport
Pathways		Defective ALG2 causes ALG2-CDG (CDG-1i) Diseases of glycosylation Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective MOGS causes MOGS-CDG (CDG-2b) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective RFT1 causes RFT1-CDG (CDG-1n) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins Defective ALG11 causes ALG11-CDG (CDG-1p)
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: ANXA11 PEF1 PTPN23 SRI	9 interactors: ALG2 CEP55 CHMP4B DDX24 GRB2 LRRK2 NOTCH2NL PSMA3 TRIM27
Entrez ID		85365	25930
HPRD ID		09716	05959
Ensembl ID			ENSG00000076201
Uniprot IDs		Q9H553	B4DST5 Q9H3S7
PDB IDs			3RAU
Enriched GO Terms of Interacting Partners?		Response To Calcium Ion Regulation Of Homophilic Cell Adhesion Positive Regulation Of Homophilic Cell Adhesion Intracellular Sequestering Of Iron Ion Cytokinesis, Completion Of Separation Positive Regulation Of Intracellular Transport Positive Regulation Of Early Endosome To Late Endosome Transport Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Proteolysis Regulation Of High Voltage-gated Calcium Channel Activity Response To Metal Ion Mitotic Cytokinetic Process Regulation Of Relaxation Of Muscle Negative Regulation Of Heart Rate Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Sequestering Of Metal Ion Regulation Of Early Endosome To Late Endosome Transport Regulation Of Intracellular Transport Regulation Of Cell Communication By Electrical Coupling Response To Inorganic Substance Negative Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Cell Separation After Cytokinesis Negative Regulation Of Cation Channel Activity Regulation Of Voltage-gated Calcium Channel Activity Cytoplasmic Sequestering Of Transcription Factor Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Heart Contraction Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Transcription Regulatory Region DNA Binding Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Cytoplasmic Sequestering Of Protein Positive Regulation Of Adherens Junction Organization Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cellular Component Movement Positive Regulation Of Transport Positive Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Transporter Activity Negative Regulation Of Calcium Ion Transport Mitotic Cytokinesis Regulation Of Cardiac Muscle Cell Contraction Negative Regulation Of DNA Binding Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Epithelial Cell Migration Negative Regulation Of Transcription Factor Import Into Nucleus Negative Regulation Of Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Calcium Ion Transmembrane Transport Regulation Of Cellular Localization	Cell Separation After Cytokinesis Regulation Of Viral Release From Host Cell Positive Regulation Of Proteolysis Regulation Of Protein Complex Assembly Regulation Of Organelle Organization Protein Localization Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion Negative Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Thioredoxin Peroxidase Activity By Peptidyl-threonine Phosphorylation Protein Glycosylation In Endoplasmic Reticulum Negative Regulation Of Peroxidase Activity Negative Regulation Of Signal Transduction Protein Oligomerization Signal Transduction In Response To DNA Damage Negative Regulation Of Signaling Regulation Of Cytoskeleton Organization Positive Regulation Of Actin Filament Polymerization Regulation Of Autophagy Negative Regulation Of Interleukin-2 Secretion Negative Regulation Of Late Endosome To Lysosome Transport Positive Regulation Of Protein Autoubiquitination Positive Regulation Of Protein Polymerization Viral Process Cellular Response To Dopamine Negative Regulation Of Autophagic Vacuole Assembly Regulation Of Protein Autoubiquitination Positive Regulation Of Dopamine Receptor Signaling Pathway Maintenance Of Lens Transparency Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Vesicle-mediated Transport Establishment Of Protein Localization Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Protein Targeting To Mitochondrion Regulation Of Branching Morphogenesis Of A Nerve Regulation Of Kidney Size Regulation Of Viral Process Cellular Response To Stress Regulation Of Proteolysis Mitotic Cell Cycle Process Regulation Of Cell Death Protein Polyubiquitination Positive Regulation Of Protein Complex Assembly Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Cellular Response To Manganese Ion Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Actin Filament Polymerization Negative Regulation Of Protein Transport Negative Regulation Of Calcium Ion Import Intracellular Distribution Of Mitochondria
Tagcloud ?		aip autophagosomal bip calcineurin csa culminated cycloheximide cyclophilin cyclosporine fk506 immunosuppressant ire1alpha lacked lacuna lc3ii paraptosis paraptotic ppiase preceded redirecting resident ruled salubrinal siha tacrolimus vacuolated vacuolation vacuolations vacuoles
Tagcloud (Difference) ?		aip autophagosomal bip calcineurin csa culminated cycloheximide cyclophilin cyclosporine fk506 immunosuppressant ire1alpha lacked lacuna lc3ii paraptosis paraptotic ppiase preceded redirecting resident ruled salubrinal siha tacrolimus vacuolated vacuolation vacuolations vacuoles
Tagcloud (Intersection) ?