ALG2 and ANXA11

Number of citations of the paper that reports this interaction (PMID 11883939)
10

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, two hybrid)

		ALG2	ANXA11
Gene Name		ALG2, alpha-1,3/1,6-mannosyltransferase	annexin A11
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Perinuclear Region Of Cytoplasm	Nuclear Envelope Nucleoplasm Cytoplasm Spindle Membrane Midbody Melanosome Specific Granule Azurophil Granule Phagocytic Vesicle Extracellular Vesicular Exosome
	Molecular Function	Alpha-1,3-mannosyltransferase Activity GDP-Man:Man1GlcNAc2-PP-Dol Alpha-1,3-mannosyltransferase Activity Protein Binding Glycolipid 6-alpha-mannosyltransferase Activity Protein Heterodimerization Activity Protein N-terminus Binding Calcium-dependent Protein Binding	Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Phosphatidylethanolamine Binding MHC Class II Protein Complex Binding S100 Protein Binding Poly(A) RNA Binding Calcium-dependent Protein Binding
	Biological Process	Dolichol-linked Oligosaccharide Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Protein Glycosylation In Endoplasmic Reticulum Post-translational Protein Modification Cellular Protein Metabolic Process Response To Calcium Ion Mannosylation	Phagocytosis Cytokinesis, Completion Of Separation Response To Calcium Ion
Pathways		Defective ALG2 causes ALG2-CDG (CDG-1i) Diseases of glycosylation Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective MOGS causes MOGS-CDG (CDG-2b) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective RFT1 causes RFT1-CDG (CDG-1n) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins Defective ALG11 causes ALG11-CDG (CDG-1p)
Drugs
Diseases
GWAS			Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Sarcoidosis ( 22936702)
Protein-Protein Interactions		4 interactors: ANXA11 PEF1 PTPN23 SRI	10 interactors: ALG2 CEP55 ENO2 HNRNPH3 PDCD6 PLSCR1 S100A6 SRI TFG ZDHHC17
Entrez ID		85365	311
HPRD ID		09716	03983
Ensembl ID			ENSG00000122359
Uniprot IDs		Q9H553	B4DVE7 P50995 Q5T0G8
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Calcium Ion Regulation Of Homophilic Cell Adhesion Positive Regulation Of Homophilic Cell Adhesion Intracellular Sequestering Of Iron Ion Cytokinesis, Completion Of Separation Positive Regulation Of Intracellular Transport Positive Regulation Of Early Endosome To Late Endosome Transport Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Proteolysis Regulation Of High Voltage-gated Calcium Channel Activity Response To Metal Ion Mitotic Cytokinetic Process Regulation Of Relaxation Of Muscle Negative Regulation Of Heart Rate Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Sequestering Of Metal Ion Regulation Of Early Endosome To Late Endosome Transport Regulation Of Intracellular Transport Regulation Of Cell Communication By Electrical Coupling Response To Inorganic Substance Negative Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Cell Separation After Cytokinesis Negative Regulation Of Cation Channel Activity Regulation Of Voltage-gated Calcium Channel Activity Cytoplasmic Sequestering Of Transcription Factor Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Heart Contraction Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Transcription Regulatory Region DNA Binding Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Cytoplasmic Sequestering Of Protein Positive Regulation Of Adherens Junction Organization Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cellular Component Movement Positive Regulation Of Transport Positive Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Transporter Activity Negative Regulation Of Calcium Ion Transport Mitotic Cytokinesis Regulation Of Cardiac Muscle Cell Contraction Negative Regulation Of DNA Binding Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Epithelial Cell Migration Negative Regulation Of Transcription Factor Import Into Nucleus Negative Regulation Of Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Calcium Ion Transmembrane Transport Regulation Of Cellular Localization	Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of TOR Signaling Negative Regulation Of Protein Kinase B Signaling Positive Regulation Of Endothelial Cell Migration Regulation Of TOR Signaling Positive Regulation Of Endothelial Cell Proliferation Cellular Response To Heat Protein Glycosylation In Endoplasmic Reticulum Positive Regulation Of Epithelial Cell Migration Regulation Of Endothelial Cell Proliferation Protein Localization Regulation Of Signaling Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Intracellular Sequestering Of Iron Ion Zymogen Activation Regulation Of Endothelial Cell Migration Negative Regulation Of Cellular Response To Growth Factor Stimulus Response To Heat Response To Calcium Ion Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Protein Kinase B Signaling Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Positive Regulation Of Angiogenesis Positive Regulation Of Endopeptidase Activity Regulation Of Epithelial Cell Migration Positive Regulation Of Peptidase Activity Positive Regulation Of Epithelial Cell Proliferation Establishment Of Protein Localization Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Phosphatidylserine Biosynthetic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cellular Component Movement Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of High Voltage-gated Calcium Channel Activity Response To Temperature Stimulus Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Signal Transduction Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Relaxation Of Muscle Regulation Of Angiogenesis Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cell Proliferation Regulation Of Intracellular Signal Transduction Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Tagcloud ?		aip autophagosomal bip calcineurin csa culminated cycloheximide cyclophilin cyclosporine fk506 immunosuppressant ire1alpha lacked lacuna lc3ii paraptosis paraptotic ppiase preceded redirecting resident ruled salubrinal siha tacrolimus vacuolated vacuolation vacuolations vacuoles	alg apparatus architectural associates cage cargo cargoes coat coordinating copii ef eres exit golgi juxtanuclear maintains penta periphery physically scattering sec31a secretory specialized stabilize synchronous trafficking vesicle vesicular
Tagcloud (Difference) ?		aip autophagosomal bip calcineurin csa culminated cycloheximide cyclophilin cyclosporine fk506 immunosuppressant ire1alpha lacked lacuna lc3ii paraptosis paraptotic ppiase preceded redirecting resident ruled salubrinal siha tacrolimus vacuolated vacuolation vacuolations vacuoles	alg apparatus architectural associates cage cargo cargoes coat coordinating copii ef eres exit golgi juxtanuclear maintains penta periphery physically scattering sec31a secretory specialized stabilize synchronous trafficking vesicle vesicular
Tagcloud (Intersection) ?