ATCAY and KLC1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ATCAY	KLC1
Description		ATCAY kinesin light chain interacting caytaxin	kinesin light chain 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Axon Dendrite Growth Cone Mitochondrial Membrane Cell Projection Neuron Projection Neuron Projection Terminus Synapse Perinuclear Region Of Cytoplasm Presynapse	Cytoplasm Cytosol Cytoskeleton Kinesin Complex Microtubule Membrane Growth Cone Cytoplasmic Vesicle Cell Projection
	Molecular Function	Protein Binding Kinesin Binding	Cytoskeletal Motor Activity Protein Binding Kinesin Binding
	Biological Process	Apoptotic Process Nervous System Development Neuron Projection Development Regulation Of Protein Localization Mitochondrion Distribution Negative Regulation Of Glutamate Metabolic Process	Microtubule-based Movement Cell Adhesion Stress Granule Disassembly
Pathways			MHC class II antigen presentation RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Signaling by ALK fusions and activated point mutants Kinesins
Drugs
Diseases		Cerebellar ataxia cayman type (ATCAY); Cayman ataxia
GWAS		Aging (time to event) ( 21782286)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Body mass index ( 25673413 28892062) Brain morphology (MOSTest) ( 32665545) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Schizophrenia ( 25056061) Smoking behaviour (cigarette pack-years) ( 30679032) Urate levels ( 31578528)
Interacting Genes		5 interacting genes: APP FATE1 KLC1 PIN1 STUB1	29 interacting genes: ADRB2 AP1AR APP ATCAY BNIP2 CLSTN1 ERBB2 F2RL1 HSPB1 KIF2A KIF5C KLC2 KRT31 LRSAM1 MAPK6 MAPK8IP1 MAPK8IP2 MAPK8IP3 NIN ODAD1 ODF1 PCM1 PLEKHM2 PTGER4 SNCA SPAG9 TACC3 TSC1 YWHAB
Entrez ID		85300	3831
HPRD ID		10491	02489
Ensembl ID		ENSG00000167654	ENSG00000126214
Uniprot IDs		A0A0S2Z5T8 Q86WG3	F8W6L3 G3V2E7 G3V3H3 G3V5R9 G5E9S8 Q07866 Q7RTQ2
PDB IDs			3NF1 5OJ8 7AI4 7AIE
Enriched GO Terms of Interacting Partners?		Amyloid-beta Complex Regulation Of Amyloid Precursor Protein Catabolic Process Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway G Protein-coupled Receptor Binding Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Protein Catabolic Process Cytoskeletal Motor Activity Cis-trans Isomerase Activity Tau Protein Binding Positive Regulation Of Chaperone-mediated Protein Complex Assembly Acetylcholine Receptor Activator Activity Protein-folding Chaperone Binding PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Growth Cone Lipoprotein Particle Regulation Of Protein Localization To Nucleus Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Cellular Response To Hypoxia Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Peptidyl-prolyl Isomerization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Phosphothreonine Residue Binding Negative Regulation Of Vascular Associated Smooth Muscle Contraction Microtubule-based Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Protein Metabolic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intracellular Signaling Cassette Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Ubiquitin Conjugating Enzyme Complex Negative Regulation Of Mitochondrial Calcium Ion Concentration Positive Regulation Of Proteolysis Intermediate-density Lipoprotein Particle	Kinesin Binding MAP-kinase Scaffold Activity JUN Kinase Binding Protein Localization To Synapse Positive Regulation Of MAPK Cascade Microtubule-based Process Perinuclear Region Of Cytoplasm Microtubule-based Movement Protein Localization To Cell Junction Anterograde Axonal Protein Transport Protein Transport Along Microtubule Organelle Localization Regulation Of MAPK Cascade MAPK Cascade Regulation Of JNK Cascade Cytoskeleton Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Projection Axonal Growth Cone Axo-dendritic Transport Transport Along Microtubule Ciliary Basal Body Lysosome Cytoskeleton-dependent Intracellular Transport Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of JNK Cascade Microtubule-based Transport Regulation Of Supramolecular Fiber Organization Protein-containing Complex Leukocyte Activation Anterograde Axonal Transport Protein Kinase Inhibitor Activity Kinesin Complex Axon Modulation Of Excitatory Postsynaptic Potential Receptor Localization To Synapse Positive Regulation Of Signal Transduction Centriolar Subdistal Appendage Mitotic Spindle Growth Cone Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Cell Projection Organization Intracellular Signaling Cassette Lysosome Localization Microtubule Anchoring At Centrosome Regulation Of G Protein-coupled Receptor Signaling Pathway Cytoplasm Cell Activation JNK Cascade
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