GCM1 and SENP1

Number of citations: 38 (PubMedID 21791615)
Data Source: BioGRID (pull down)

		GCM1	SENP1
Name		glial cells missing transcription factor 1	SUMO specific peptidase 1
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex	Nucleus Nucleoplasm Cytoplasm Focal Adhesion Nuclear Membrane Glutamatergic Synapse Presynaptic Cytosol Postsynaptic Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Histone Deacetylase Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity DeSUMOylase Activity SUMO-specific Endopeptidase Activity
	Biological Process	Syncytium Formation By Plasma Membrane Fusion Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Anatomical Structure Morphogenesis Gliogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Astrocyte Fate Commitment Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Branching Involved In Labyrinthine Layer Morphogenesis Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Cell Differentiation Involved In Embryonic Placenta Development	Proteolysis Regulation Of Definitive Erythrocyte Differentiation Protein Sumoylation Protein Desumoylation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of MRNA Stability Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process MRNA Destabilization Regulation Of Primary Metabolic Process Regulation Of Postsynapse Assembly
Pathways		None	SUMO is proteolytically processed RHOF GTPase cycle
GWAS		Cerebrospinal fluid AB1-42 levels ( 26252872 )	Glycated hemoglobin levels ( 28898252 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Macular thickness ( 30535121 ) Reticulocyte count ( 32888494 ) Rheumatoid arthritis ( 30891314 )
Interacting Genes		9 interacting genes: CAMK1 CREBBP DUSP23 HDAC1 HDAC3 HDAC4 HDAC5 SENP1 UBE2I	26 interacting genes: APP CAV3 EIF5A GCM1 HDAC1 HIPK1 HIPK2 KCNK1 MORC2 NACC1 PARP1 PIAS3 PIM1 PML RABGAP1 RANBP2 RANGAP1 RPL11 SP100 SUMO1 SUMO2 SUMO3 UBE2K USP25 USP28 USP7
Entrez ID		8521	29843
HPRD ID		04757	07153
Ensembl ID		ENSG00000137270	ENSG00000079387
Uniprot IDs		Q9NP62	Q9P0U3
PDB IDs		Not available	2CKG 2CKH 2G4D 2IY0 2IY1 2IYC 2IYD 2XPH 2XRE 6NNQ
GO Terms Enriched among Interactors		Histone Deacetylase Activity, Hydrolytic Mechanism Protein Lysine Deacetylase Activity Negative Regulation Of Myotube Differentiation Histone Deacetylase Activity Negative Regulation Of Striated Muscle Cell Differentiation Histone Deacetylase Complex Regulation Of Myotube Differentiation Regulation Of Muscle Cell Differentiation DNA-binding Transcription Factor Binding Protein Deacetylation Negative Regulation Of Muscle Cell Differentiation Regulation Of Striated Muscle Cell Differentiation Macromolecule Deacylation Histone Deacetylase Binding Protein Lysine Delactylase Activity Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression, Epigenetic Protein Decrotonylase Activity Histone Decrotonylase Activity Transcription Corepressor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Protein Sumoylation Negative Regulation Of Transcription By RNA Polymerase II Protein Modification Process Regulation Of Transcription By RNA Polymerase II Transcription Repressor Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Epigenetic Regulation Of Gene Expression Chromatin Remodeling Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Chromatin Organization SUMO Transferase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Cell Differentiation DNA-binding Transcription Activator Activity Hydrolase Activity Chromatin Binding Presynaptic Cytosol Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process	Protein Sumoylation Regulation Of Ubiquitin-dependent Protein Catabolic Process PML Body Regulation Of Proteolysis Protein Modification Process Post-translational Protein Modification Protein Metabolic Process Macromolecule Metabolic Process Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Binding Regulation Of Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process SUMO Transferase Activity Nucleoplasm Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process PML Body Organization Nucleus Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Signal Transduction By P53 Class Mediator Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Protein Stability Protein Tag Activity Protein-containing Complex Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Intracellular Transport Cellular Response To Stress Cytoplasmic Periphery Of The Nuclear Pore Complex DNA Damage Response Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Nuclear Body Organization Negative Regulation Of Proteolysis Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Protein Localization Deubiquitinase Activity Maintenance Of Protein Location In Nucleus Ubiquitin-like Protein Ligase Binding Nuclear Pore Presynaptic Cytosol Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Postsynaptic Cytosol Negative Regulation Of Transcription By RNA Polymerase II SUMO Ligase Complex Nuclear Pore Cytoplasmic Filaments