GCM1 and CDH16

Data Source: HiPPIP (Novel)

		GCM1	CDH16
Name		glial cells missing transcription factor 1	cadherin 16
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex	Plasma Membrane Membrane Basolateral Plasma Membrane Synapse Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Histone Deacetylase Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Calcium Ion Binding Protein Binding Metal Ion Binding Cell Adhesion Molecule Binding
	Biological Process	Syncytium Formation By Plasma Membrane Fusion Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Anatomical Structure Morphogenesis Gliogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Astrocyte Fate Commitment Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Branching Involved In Labyrinthine Layer Morphogenesis Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Cell Differentiation Involved In Embryonic Placenta Development	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell-cell Adhesion
GWAS		Cerebrospinal fluid AB1-42 levels ( 26252872 )	HDL cholesterol levels in current drinkers ( 30698716 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 )
Novel Interactors		1 novel interactors: CDH16	7 novel interactors: ATP2A3 CDH5 GCM1 MRPL52 NDUFS8 NQO1 TUBB
Interacting Genes		9 interacting genes: CAMK1 CREBBP DUSP23 HDAC1 HDAC3 HDAC4 HDAC5 SENP1 UBE2I	2 interacting genes: CTNNB1 G6PC1
Entrez ID		8521	1014
HPRD ID		04757	11929
Ensembl ID		ENSG00000137270	ENSG00000166589
Uniprot IDs		Q9NP62	O75309
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Histone Deacetylase Activity, Hydrolytic Mechanism Protein Lysine Deacetylase Activity Negative Regulation Of Myotube Differentiation Histone Deacetylase Activity Negative Regulation Of Striated Muscle Cell Differentiation Histone Deacetylase Complex Regulation Of Myotube Differentiation Regulation Of Muscle Cell Differentiation DNA-binding Transcription Factor Binding Protein Deacetylation Negative Regulation Of Muscle Cell Differentiation Regulation Of Striated Muscle Cell Differentiation Macromolecule Deacylation Histone Deacetylase Binding Protein Lysine Delactylase Activity Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression, Epigenetic Protein Decrotonylase Activity Histone Decrotonylase Activity Transcription Corepressor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Protein Sumoylation Negative Regulation Of Transcription By RNA Polymerase II Protein Modification Process Regulation Of Transcription By RNA Polymerase II Transcription Repressor Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Epigenetic Regulation Of Gene Expression Chromatin Remodeling Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Chromatin Organization SUMO Transferase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Cell Differentiation DNA-binding Transcription Activator Activity Hydrolase Activity Chromatin Binding Presynaptic Cytosol Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process	Response To Caloric Restriction Transmembrane Transporter Binding Catenin Complex Homeostatic Process Calcium-dependent ATPase Activity Calcium Ion Transport From Cytosol To Endoplasmic Reticulum Regulation Of Endothelial Cell Differentiation Cell Periphery Cell-cell Junction Assembly Protein Phosphatase Binding Cell-cell Adhesion Mediated By Cadherin Adherens Junction Organization Bicellular Tight Junction Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Mesenchymal Stem Cell Differentiation Oviduct Development Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Beta-catenin-ICAT Complex Negative Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Acinar Cell Differentiation Positive Regulation Of Proteoglycan Biosynthetic Process Fungiform Papilla Formation Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Beta-catenin-TCF7L2 Complex Glial Cell Fate Determination Astrocyte-dopaminergic Neuron Signaling Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Metanephros Morphogenesis Trachea Morphogenesis Regulation Of Mitotic Cell Cycle, Embryonic Renal Inner Medulla Development Scrib-APC-beta-catenin Complex Regulation Of Centriole-centriole Cohesion Renal Outer Medulla Development Renal Vesicle Formation Embryonic Skeletal Limb Joint Morphogenesis Glial Cell-neuron Signaling Lung Induction Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Positive Regulation Of Branching Involved In Lung Morphogenesis Neural Plate Development Catenin-TCF7L2 Complex NADH Dehydrogenase (quinone) (non-electrogenic) Activity NADPH Dehydrogenase (quinone) Activity NAD(P)H Dehydrogenase (quinone) Activity Response To Resveratrol Glucose-6-phosphatase Activity Astrocyte Fate Commitment