TMEM60 and STX1A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM60	STX1A
Description		transmembrane protein 60	syntaxin 1A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Membrane	Extracellular Region Cytosol Plasma Membrane Synaptic Vesicle Voltage-gated Potassium Channel Complex Endomembrane System Membrane Secretory Granule Axon Synaptic Vesicle Membrane SNARE Complex Cytoplasmic Vesicle Nuclear Membrane Protein-containing Complex Actomyosin Presynaptic Membrane Neuron Projection Synapse Presynaptic Active Zone Membrane Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Protein Binding	SNARE Binding SNAP Receptor Activity Protein Binding Myosin Binding Calcium Channel Inhibitor Activity Chloride Channel Inhibitor Activity Kinase Binding Protein-macromolecule Adaptor Activity Myosin Head/neck Binding Identical Protein Binding ATP-dependent Protein Binding Transmembrane Transporter Binding Protein-containing Complex Binding Calcium-dependent Protein Binding
	Biological Process		Positive Regulation Of Neurotransmitter Secretion Neurotransmitter Transport Intracellular Protein Transport Exocytosis Vesicle Fusion Response To Gravity Positive Regulation Of Norepinephrine Secretion Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Exocytosis Synaptic Vesicle Docking Vesicle-mediated Transport Protein Sumoylation Calcium-ion Regulated Exocytosis Regulation Of Exocytosis Insulin Secretion Secretion By Cell Positive Regulation Of Catecholamine Secretion SNARE Complex Assembly Regulated Exocytosis Positive Regulation Of Exocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis Hormone Secretion Vesicle Docking Synaptic Vesicle Endocytosis Regulation Of Insulin Secretion Protein Localization To Membrane Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Excitatory Postsynaptic Potential
Pathways			Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Insulin processing Regulation of insulin secretion Other interleukin signaling Toxicity of botulinum toxin type C (botC) LGI-ADAM interactions Neurexins and neuroligins GABA synthesis, release, reuptake and degradation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Sensory processing of sound by inner hair cells of the cochlea
Drugs
Diseases
GWAS		Chronic kidney disease ( 20383146) Estimated glomerular filtration rate ( 30604766 31152163 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate (creatinine) ( 26831199 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199)	Hip circumference adjusted for BMI ( 34021172) Malaria ( 31844061) Triglyceride levels ( 32203549)
Interacting Genes		91 interacting genes: AMIGO1 ANKS6 APOL2 AQP2 AQP6 ARL13B ASGR2 BEST2 BIK BSND CD300A CD53 CD74 CLDN7 CNR2 CPLX4 CYB5R3 EBP EDA ERGIC3 EVI2B FAM209A FFAR2 FNDC9 GJA8 GJB5 GJB6 GORAB GPR152 GPR42 GPX8 HERPUD2 HIBADH HSD17B13 IFNGR2 KCNK5 KIAA2013 LEUTX LHFPL5 LMNA LRRC3B LRRC59 MFF MGST3 MMD MMGT1 PAGE1 PGRMC2 PI16 REEP2 REEP4 RETREG3 RHCG RNASEK SCN3B SLC10A1 SLC10A6 SLC13A4 SLC16A2 SLC18A1 SLC23A2 SLC30A2 SLC30A4 SLC35E3 SLC35H1 SLC38A1 SLC39A2 SLC4A1 SLC7A8 SPAG4 SPNS3 SSMEM1 STOM STX1A SYT1 THAP4 TLCD4 TMCO5A TMED9 TMEM139 TMEM14B TMEM203 TMEM237 TMEM45B TMEM52B TMEM86B TMEM9 TMPPE TMPRSS2 TTYH1 VMA21	169 interacting genes: AARD ABCC9 ABI3 AGTRAP AIG1 ANKRD46 AOC3 APBA1 APOL2 APOL3 AQP3 ARL13B ARLN ATP4B ATP6V1B1 BET1 BLOC1S6 BNIP1 BTN2A2 C1GALT1 CACNA1D CCSER2 CD81 CDC37 CDK5 CFTR CLEC1A CLN6 CMTM7 CPLX1 CSNK2A1 CSNK2A2 CXCL16 CYB5B DAPK1 DDX49 DSCR9 DYRK1A EBAG9 EMD ERG28 ETNK2 FAM3C GIMAP1 GIMAP5 GOLM2 GOSR2 GPM6B HMOX1 JAGN1 KCNB1 KIFC3 MAL MALL MIP MMGT1 NAPA NAPB NINJ2 NKG7 NRM NSF PGAP2 PLN PLP1 PLPP4 PLPP6 PNLIPRP1 PSMA3 RAB27A RAB3IL1 RIMS1 RMDN2 RNF4 RTP2 SCNN1A SCNN1B SCNN1G SDCBP SEC22A SEC22B SEPTIN2 SEPTIN5 SERP1 SERP2 SLC6A1 SLC6A2 SLC6A3 SLC6A4 SLC6A5 SLC6A9 SMIM1 SMIM3 SNAP23 SNAP25 SNAP29 SNAP47 SNORC SNPH STRIT1 STX10 STX11 STX12 STX16 STX2 STX3 STX4 STX5 STX6 STX7 STX8 STXBP1 STXBP2 STXBP5 STXBP6 SUMO1P1 SYT1 SYT4 SYT7 SYTL4 TCEANC TMEM100 TMEM120A TMEM128 TMEM14C TMEM222 TMEM254 TMEM41A TMEM60 TNF TRAF3IP3 TRDMT1 TSGA10IP TSNARE1 TXLNA TXLNB UBE2I UBTFL1 UNC13B UPK1B USE1 VAMP1 VAMP2 VAMP3 VAMP4 VAMP5 VAMP7 VAMP8 VAPB VIM VMA12 VPS11 VPS16 VPS18 VSTM4 VTI1B ZFPL1 ZNF12 ZNF136 ZNF250 ZNF440 ZNF441 ZNF479 ZNF490 ZNF557 ZNF696 ZNF707 ZNF785 ZNF835
Entrez ID		85025	6804
HPRD ID		12923	01721
Ensembl ID		ENSG00000135211	ENSG00000106089
Uniprot IDs		Q9H2L4	A0A0C4DFZ1 A8MZ54 Q16623 Q75ME0
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Transmembrane Transport Protein Binding Monoatomic Ion Transport Plasma Membrane Basolateral Plasma Membrane Inorganic Ion Transmembrane Transport Monoatomic Cation Transport Endoplasmic Reticulum Membrane Transport Vesicle Membrane Monoatomic Ion Transmembrane Transport Endoplasmic Reticulum Antiporter Activity Metal Ion Transport Organic Anion Transport Inorganic Cation Transmembrane Transport Inorganic Anion Transmembrane Transport Cytoplasmic Vesicle Zinc Export Across Plasma Membrane Inorganic Anion Transport Monoatomic Cation Transmembrane Transport Connexin Complex Chloride Transmembrane Transport Gap Junction Channel Activity Regulation Of PH Symporter Activity Neurotransmitter Transport Zinc Ion Import Into Lysosome Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Organization Carbon Dioxide Transmembrane Transporter Activity Chloride Transport Carbon Dioxide Transmembrane Transport Bile Acid:sodium Symporter Activity Clathrin-sculpted Monoamine Transport Vesicle Membrane Zinc Ion Transmembrane Transporter Activity Lysosomal Lumen Acidification Gap Junction Zinc Ion Transmembrane Transport Transmembrane Transporter Activity Zinc Ion Transport Gap Junction-mediated Intercellular Transport Sodium Ion Transport Carboxylic Acid Transmembrane Transport Organic Acid Transmembrane Transport Carboxylic Acid Transport Organic Acid Transport Amino Acid Transmembrane Transporter Activity Thyroid Hormone Transmembrane Transporter Activity Proton-transporting V-type ATPase Complex Assembly	SNAP Receptor Activity SNARE Complex Membrane Fusion Organelle Localization By Membrane Tethering Organelle Membrane Fusion Syntaxin Binding Vesicle Fusion Membrane Docking Vesicle Docking Organelle Fusion SNARE Binding Vesicle Organization Membrane Organization Vesicle-mediated Transport Exocytosis Secretion By Cell Membrane Syntaxin-1 Binding Secretion Establishment Of Localization In Cell Establishment Of Protein Localization Organelle Localization Protein Transport Regulation Of Exocytosis Vesicle Docking Involved In Exocytosis Endomembrane System Cellular Localization Intracellular Protein Localization SNARE Complex Assembly Neurotransmitter Transport Positive Regulation Of Exocytosis Regulated Exocytosis Regulation Of Secretion By Cell Calcium-ion Regulated Exocytosis Synaptic Vesicle Priming Regulation Of Regulated Secretory Pathway Regulation Of Secretion Intracellular Protein Transport Intracellular Transport Golgi Vesicle Transport Signal Release Synaptic Vesicle Exocytosis Positive Regulation Of Regulated Secretory Pathway Regulation Of Vesicle-mediated Transport Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Fusion To Plasma Membrane Presynapse Regulation Of Transport Vesicle-mediated Transport In Synapse Chloride Channel Inhibitor Activity
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