TMEM60 and TTYH1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM60	TTYH1
Description		transmembrane protein 60	tweety family member 1
Image		No pdb structure
GO Annotations	Cellular Component	Membrane	Plasma Membrane Membrane Smooth Endoplasmic Reticulum Membrane Filopodium Membrane Filopodium Tip Chloride Channel Complex Synapse
	Molecular Function	Protein Binding	Volume-sensitive Anion Channel Activity Intracellularly Calcium-gated Chloride Channel Activity Chloride Channel Activity Iron Ion Transmembrane Transporter Activity Calcium Ion Binding Protein Binding Volume-sensitive Chloride Channel Activity
	Biological Process		Mitotic Cell Cycle Cell Morphogenesis Monoatomic Ion Transport Chloride Transport Iron Ion Transport Cell Adhesion Notch Signaling Pathway Gene Expression L-glutamate Transmembrane Transport Neurogenesis Cell-substrate Adhesion Monoatomic Ion Transmembrane Transport Iron Ion Transmembrane Transport Filopodium Assembly Stem Cell Differentiation Stem Cell Proliferation Cell-cell Adhesion Chloride Transmembrane Transport
Pathways
Drugs
Diseases
GWAS		Chronic kidney disease ( 20383146) Estimated glomerular filtration rate ( 30604766 31152163 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate (creatinine) ( 26831199 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199)	Blood trace element (Se levels) ( 23720494) Idiopathic pulmonary fibrosis ( 29066090)
Interacting Genes		91 interacting genes: AMIGO1 ANKS6 APOL2 AQP2 AQP6 ARL13B ASGR2 BEST2 BIK BSND CD300A CD53 CD74 CLDN7 CNR2 CPLX4 CYB5R3 EBP EDA ERGIC3 EVI2B FAM209A FFAR2 FNDC9 GJA8 GJB5 GJB6 GORAB GPR152 GPR42 GPX8 HERPUD2 HIBADH HSD17B13 IFNGR2 KCNK5 KIAA2013 LEUTX LHFPL5 LMNA LRRC3B LRRC59 MFF MGST3 MMD MMGT1 PAGE1 PGRMC2 PI16 REEP2 REEP4 RETREG3 RHCG RNASEK SCN3B SLC10A1 SLC10A6 SLC13A4 SLC16A2 SLC18A1 SLC23A2 SLC30A2 SLC30A4 SLC35E3 SLC35H1 SLC38A1 SLC39A2 SLC4A1 SLC7A8 SPAG4 SPNS3 SSMEM1 STOM STX1A SYT1 THAP4 TLCD4 TMCO5A TMED9 TMEM139 TMEM14B TMEM203 TMEM237 TMEM45B TMEM52B TMEM86B TMEM9 TMPPE TMPRSS2 TTYH1 VMA21	6 interacting genes: CCR9 DRD2 DSCR9 GPR37 HTR6 TMEM60
Entrez ID		85025	57348
HPRD ID		12923	12043
Ensembl ID		ENSG00000135211	ENSG00000167614
Uniprot IDs		Q9H2L4	Q9H313
PDB IDs			7P5J
Enriched GO Terms of Interacting Partners?		Membrane Transmembrane Transport Protein Binding Monoatomic Ion Transport Plasma Membrane Basolateral Plasma Membrane Inorganic Ion Transmembrane Transport Monoatomic Cation Transport Endoplasmic Reticulum Membrane Transport Vesicle Membrane Monoatomic Ion Transmembrane Transport Endoplasmic Reticulum Antiporter Activity Metal Ion Transport Organic Anion Transport Inorganic Cation Transmembrane Transport Inorganic Anion Transmembrane Transport Cytoplasmic Vesicle Zinc Export Across Plasma Membrane Inorganic Anion Transport Monoatomic Cation Transmembrane Transport Connexin Complex Chloride Transmembrane Transport Gap Junction Channel Activity Regulation Of PH Symporter Activity Neurotransmitter Transport Zinc Ion Import Into Lysosome Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Organization Carbon Dioxide Transmembrane Transporter Activity Chloride Transport Carbon Dioxide Transmembrane Transport Bile Acid:sodium Symporter Activity Clathrin-sculpted Monoamine Transport Vesicle Membrane Zinc Ion Transmembrane Transporter Activity Lysosomal Lumen Acidification Gap Junction Zinc Ion Transmembrane Transport Transmembrane Transporter Activity Zinc Ion Transport Gap Junction-mediated Intercellular Transport Sodium Ion Transport Carboxylic Acid Transmembrane Transport Organic Acid Transmembrane Transport Carboxylic Acid Transport Organic Acid Transport Amino Acid Transmembrane Transporter Activity Thyroid Hormone Transmembrane Transporter Activity Proton-transporting V-type ATPase Complex Assembly	G Protein-coupled Receptor Activity Telencephalon Cell Migration G Protein-coupled Receptor Signaling Pathway Forebrain Cell Migration Catecholamine Metabolic Process Dopamine Metabolic Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Biogenic Amine Metabolic Process Amine Metabolic Process Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phenol-containing Compound Metabolic Process Dendrite G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Prosaposin Receptor Activity Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Orbitofrontal Cortex Development Negative Regulation Of Dopamine Receptor Signaling Pathway CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation Dopamine Binding Dopamine Neurotransmitter Receptor Activity Cerebral Cortex GABAergic Interneuron Migration Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Negative Regulation Of Dephosphorylation Positive Regulation Of Renal Sodium Excretion Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Hyaloid Vascular Plexus Regression Branching Morphogenesis Of A Nerve Negative Regulation Of Dopamine Secretion Positive Regulation Of Neurotransmitter Uptake Regulation Of Locomotion Involved In Locomotory Behavior Positive Regulation Of Dopamine Metabolic Process Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Histamine Receptor Activity Regulation Of Synapse Structural Plasticity Regulation Of Renal Sodium Excretion Interneuron Migration From The Subpallium To The Cortex Regulation Of Dopamine Uptake Involved In Synaptic Transmission Heterotrimeric G-protein Binding Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Phospholipase C-activating Dopamine Receptor Signaling Pathway Locomotion Involved In Locomotory Behavior Negative Regulation Of Synaptic Transmission, Glutamatergic Response To Histamine Regulation Of Dopamine Receptor Signaling Pathway Catecholamine Uptake Dopamine Uptake
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