RSPO3 and MTDH

Number of citations of the paper that reports this interaction (PubMedID 22199357)
32

Data Source:
BioGRID (unspecified method)

		RSPO3	MTDH
Description		R-spondin 3	metadherin
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Fibrillar Center Nucleus Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Bicellular Tight Junction Membrane Apical Plasma Membrane Nuclear Body Nuclear Membrane Intercellular Canaliculus Perinuclear Region Of Cytoplasm Anchoring Junction
	Molecular Function	Signaling Receptor Binding Frizzled Binding Heparin Binding	Transcription Coregulator Activity Transcription Coactivator Activity RNA Binding Double-stranded RNA Binding Protein Binding NF-kappaB Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Angiogenesis Blood Vessel Remodeling Sprouting Angiogenesis Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Canonical Wnt Signaling Pathway Branching Involved In Labyrinthine Layer Morphogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Non-canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Autophagy Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Angiogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Pathways		Regulation of FZD by ubiquitination RUNX1 regulates transcription of genes involved in WNT signaling
Drugs
Diseases
GWAS		A body shape index ( 34021172) Alanine aminotransferase levels ( 34315874) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 33547301 34315874) Blood pressure ( 23972371) Blood protein levels ( 30072576) Blood urea nitrogen levels ( 29403010 31152163) Bone mineral density ( 21533022) Bone mineral density (paediatric, skull) ( 24945404) Bone mineral density (paediatric, total body less head) ( 24945404) Bone mineral density (paediatric, upper limb) ( 24945404) Bone mineral density (spine) ( 26733130) Bone properties (heel) ( 24430505) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Bone ultrasound measurement (velocity of sound) ( 28472463) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) Cleft lip with or without cleft palate x maternal periconceptional vitamin use interaction (parent of origin effect) ( 31372216) Cortical surface area ( 32963231) Cortical volume ( 32963231) Crohn's disease ( 28067908) Diastolic blood pressure ( 27618452 27841878 28739976 29403010 30487518) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Fasting insulin ( 34059833) Femoral neck bone mineral density ( 22504420 29499414) Food addiction ( 27106561) Fractures ( 30158200 30598549) HDL cholesterol ( 24097068 30275531) HDL cholesterol levels ( 28334899 30698716 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Heel bone mineral density ( 28869591 30048462 30598549) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High density lipoprotein cholesterol levels ( 33339817) Hip circumference ( 31453325) Hip circumference adjusted for BMI ( 25673412 34021172) Hip circumference variance ( 31453325) Hip index ( 34021172) Intracranial volume ( 22504418) Iron status biomarkers ( 19084217) LDL cholesterol levels ( 32203549) LDL cholesterol levels in HIV infection ( 33109212) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Liver transplant-free survival in primary sclerosing cholangitis (time to event) ( 28779025) Liver volume ( 34128465) Low density lipoprotein cholesterol levels ( 32154731) Lung function (FVC) ( 30061609) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Male-pattern baldness ( 27182965) Mean arterial pressure ( 29403010 30487518) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (HMG CoA reductase inhibitors) ( 31015401) Menarche (age at onset) ( 27182965) Metabolic syndrome ( 31589552) Metabolite levels ( 21909109) Monobrow ( 27182965) Neutrophil percentage of white cells ( 32888494) Occipital lobe volume ( 31396565) Optic disc size ( 31809533) Pancreas volume ( 34128465) Pulse pressure ( 27841878) QT interval ( 29213071) Red blood cell count ( 27863252 32888494) Renal function-related traits (BUN) ( 22797727) Serum urea levels ( 30808845) Subcortical brain region volumes ( 25607358) Systolic blood pressure ( 27618452 27841878 28739976 30487518) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Triglyceride levels ( 28334899 32154731 32203549) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 24097068 25961943) Waist circumference ( 25673412) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500 28552196 34021172) Waist-hip index ( 34021172) Waist-hip ratio ( 20935629 23563607 25673412 28552196) Waist-to-hip ratio adjusted for BMI ( 26426971 28552196 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28270201 28448500)	Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Migraine ( 20802479) Nicotine metabolite ratio in current smokers ( 27488534) Plasma parathyroid hormone levels ( 30134803) Red cell distribution width ( 27863252 28957414 32888494) Sweet taste preference ( 32572145)
Interacting Genes		4 interacting genes: HRAS LGR4 MTDH ZNRF3	175 interacting genes: ABCA12 ABCC3 ABTB1 ACTN1 ADCK2 ADGRA2 AGAP3 ALOX5 ANKRD13D ANKRD26P1 ANPEP ARNT2 ARRDC1 AXL BCAS3 BCS1L CAPN2 CARD8 CCL20 CCN2 CCNDBP1 CCT4 CD109 CD22 CDC14B CDC42 CEP162 CLCN7 CLDN2 CLMN COL13A1 COL4A4 COL6A1 CPAP CPT2 CRIM1 CSNK2A1 CTSB CUL7 CUL9 CYFIP2 CYP27A1 CYP4V2 DMTF1 DNAH5 DNAI4 DOCK2 DOP1B DSP DUSP5 ECE1 EGFR EGR1 ELN EML1 EPHB1 EPHX2 ERCC2 ERICH6B ESAM FAM184A FANCI FASN FCGRT FLNA FLNC FN1 FOXM1 GHDC GLG1 GRID1 HACE1 HERC5 HSPG2 ICA1L IFT46 IKBKB IL17RA IL2RB IPO9 IRS2 ITGB5 ITPR3 JADE3 JAG1 KCNH1 KCNQ5 KDM6A KMT2B LAMA5 LDLRAD2 LOXL4 LRIG3 LRP1 LRP5 MAP3K12 MCM6 MEGF11 METTL3 MLPH MMP2 MNT MRC2 MRPL39 MYH9 MYL5 NEB NEO1 NFKB2 NOTCH3 NPC1 NPR1 NUP210 NXF4 OBSCN OGT OR8G5 OSMR PCCB PCDH7 PKN1 PLAT PLD2 PLEC PLEKHO2 PLXNA3 PPFIA2 PRICKLE4 PSIP1 PTHLH PWP2 RAB24 RGS13 RIN1 RIPK1 RNF123 RNF213 RSPO3 RYR1 SDK1 SELENOI SEZ6L2 SGSM2 SH2B2 SIAE SLC38A4 SLC67A1-AS SPEF2 SPRED2 SPTBN5 SQSTM1 SSH3 STEAP3 STK25 STXBP1 SYNE1 TACR2 TBC1D2B TBCD TCIRG1 TEP1 THBS1 THSD4 TINAGL1 TNS2 TOPORS TRAPPC12 TRPC4AP TUBB3 UBXN7 VIM WDFY2 WNK2 ZNF559 ZXDC
Entrez ID		84870	92140
HPRD ID		18181	17459
Ensembl ID		ENSG00000146374	ENSG00000147649
Uniprot IDs		Q9BXY4	Q86UE4
PDB IDs			4QMG
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Communication Regulation Of Signal Transduction Phospholipase C Activator Activity Oncogene-induced Cell Senescence Cell Surface Receptor Signaling Pathway Regulation Of Signaling Cell Population Proliferation GTPase Complex Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Epithelial Cell Proliferation Involved In Renal Tubule Morphogenesis Intestinal Stem Cell Homeostasis Metanephric Nephron Tubule Morphogenesis Metanephric Glomerulus Development Wnt Receptor Catabolic Process Negative Regulation Of Non-canonical Wnt Signaling Pathway Intercellular Canaliculus Regulation Of Wnt Signaling Pathway T-helper 1 Type Immune Response Protein-hormone Receptor Activity Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Signal Transduction Positive Regulation Of Ruffle Assembly Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Signaling Nephron Tubule Morphogenesis Male Genitalia Development Glomerulus Development Renal Tubule Morphogenesis Bone Remodeling Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Schwann Cell Development Receptor Catabolic Process Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Toll-like Receptor Signaling Pathway Reproductive System Development	Anatomical Structure Formation Involved In Morphogenesis Plasma Membrane Developmental Process Cell Adhesion Extracellular Exosome Cell Surface Receptor Signaling Pathway Angiogenesis Cell-cell Fusion Syncytium Formation Syncytium Formation By Plasma Membrane Fusion Receptor Complex Myoblast Fusion Regulation Of Cellular Component Organization Cell Migration Actin Cytoskeleton Organization Cytoskeleton Organization Extracellular Matrix Endodermal Cell Differentiation Actin Filament Binding Homotypic Cell-cell Adhesion Cell-cell Adhesion Z Disc Regulation Of Signaling Cell Motility Ameboidal-type Cell Migration Actin Filament-based Process Membrane Protein Maturation Collagen V Binding Organelle Organization Focal Adhesion Signal Transduction Integrin Binding Cell Morphogenesis Regulation Of Cell Communication Hair Cycle Process Regulation Of Actin Filament-based Process Anatomical Structure Morphogenesis Cytoskeleton Extracellular Matrix Structural Constituent Skin Development Virus Receptor Activity Cell-substrate Adhesion Golgi Organization Symbiont Entry Into Host Cell Tissue Remodeling Sarcomere Proteoglycan Binding Insulin-like Growth Factor Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway
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