RSPO3 and LGR4

Number of citations of the paper that reports this interaction (PMID 24050775)
2

Data Source:
BioGRID (fluorescent resonance energy transfer)

		RSPO3	LGR4
Gene Name		R-spondin 3	leucine-rich repeat containing G protein-coupled receptor 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	G-protein Coupled Receptor Binding Receptor Binding Frizzled Binding Heparin Binding	Transmembrane Signaling Receptor Activity G-protein Coupled Receptor Activity Protein Binding
	Biological Process	Canonical Wnt Signaling Pathway Branching Involved In Labyrinthine Layer Morphogenesis Positive Regulation Of Canonical Wnt Signaling Pathway	Osteoblast Differentiation G-protein Coupled Receptor Signaling Pathway Spermatogenesis Bone Mineralization Male Genitalia Development Circadian Regulation Of Gene Expression Negative Regulation Of Toll-like Receptor Signaling Pathway Innate Immune Response Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Bone Remodeling Epithelial Cell Proliferation Negative Regulation Of Cytokine Secretion Canonical Wnt Signaling Pathway Involved In Metanephric Kidney Development Cell Differentiation Involved In Metanephros Development Metanephric Glomerulus Development Metanephric Nephron Tubule Morphogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation regulation of FZD by ubiquitination XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer	misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation regulation of FZD by ubiquitination XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS		Bone mineral density ( 21533022 22504420) Intracranial volume ( 22504418) Iron status biomarkers ( 19084217) Metabolite levels ( 21909109) Renal function-related traits (BUN) ( 22797727) Waist-hip ratio ( 23563607 20935629)
Protein-Protein Interactions		1 interactors: LGR4	3 interactors: RSPO2 RSPO3 RSPO4
Entrez ID		84870	55366
HPRD ID		18181	05978
Ensembl ID			ENSG00000205213
Uniprot IDs		Q9BXY4	Q59ER8 Q9BXB1
PDB IDs			4KT1
Enriched GO Terms of Interacting Partners?		Canonical Wnt Signaling Pathway Involved In Metanephric Kidney Development Metanephric Nephron Tubule Morphogenesis Cell Differentiation Involved In Metanephros Development Metanephric Tubule Morphogenesis Metanephric Glomerulus Development Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Metanephric Nephron Tubule Development Regulation Of Branching Involved In Ureteric Bud Morphogenesis Metanephric Nephron Morphogenesis Negative Regulation Of Toll-like Receptor Signaling Pathway Male Genitalia Development Metanephric Epithelium Development Metanephros Morphogenesis Negative Regulation Of Cytokine Secretion Positive Regulation Of Kidney Development Cell Differentiation Involved In Kidney Development Metanephric Nephron Development Regulation Of Toll-like Receptor Signaling Pathway Bone Mineralization Genitalia Development Bone Remodeling Glomerulus Development Regulation Of Morphogenesis Of A Branching Structure Biomineral Tissue Development Circadian Regulation Of Gene Expression Nephron Morphogenesis Renal Tubule Morphogenesis Epithelial Cell Proliferation Canonical Wnt Signaling Pathway Renal Tubule Development Negative Regulation Of Protein Secretion Kidney Morphogenesis Metanephros Development Tissue Remodeling Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cytokine Secretion Osteoblast Differentiation Nephron Development Positive Regulation Of Wnt Signaling Pathway Kidney Epithelium Development Negative Regulation Of Secretion By Cell Circadian Rhythm Negative Regulation Of Secretion Regulation Of Organ Morphogenesis Negative Regulation Of Protein Transport Male Sex Differentiation Negative Regulation Of Cytokine Production Regulation Of Canonical Wnt Signaling Pathway Wnt Signaling Pathway Ossification	Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Positive Regulation Of Signal Transduction Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Lung Growth Trachea Cartilage Morphogenesis Trachea Cartilage Development Branching Involved In Labyrinthine Layer Morphogenesis Morphogenesis Of An Epithelium Regulation Of Signal Transduction Trachea Morphogenesis Cartilage Morphogenesis Embryonic Morphogenesis Tissue Morphogenesis Regulation Of Signaling Cell Surface Receptor Signaling Pathway Labyrinthine Layer Morphogenesis Trachea Development Embryonic Placenta Morphogenesis Epithelial Tube Branching Involved In Lung Morphogenesis Bone Mineralization Embryonic Forelimb Morphogenesis Epithelium Development Embryonic Hindlimb Morphogenesis Forelimb Morphogenesis Embryo Development Hindlimb Morphogenesis Labyrinthine Layer Development Lung Morphogenesis Biomineral Tissue Development Signal Transduction Canonical Wnt Signaling Pathway Organ Growth Signaling Cell Communication Embryonic Placenta Development Tissue Development Osteoblast Differentiation Embryonic Limb Morphogenesis Cellular Response To Stimulus Limb Morphogenesis Cartilage Development Placenta Development Limb Development Branching Morphogenesis Of An Epithelial Tube Anatomical Structure Morphogenesis
Tagcloud ?			293t aquaporin bring cdnas conditioned conservation dependently ectodomain ed endogenously gonadal gonads intraperitoneal leucine lh named naturally newborn norrin rodent rspo2 splice spondin spondins steroidogenic superovulated testicular tune wnt
Tagcloud (Difference) ?			293t aquaporin bring cdnas conditioned conservation dependently ectodomain ed endogenously gonadal gonads intraperitoneal leucine lh named naturally newborn norrin rodent rspo2 splice spondin spondins steroidogenic superovulated testicular tune wnt
Tagcloud (Intersection) ?