RSPO3

Gene Name		R-spondin 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space
	Molecular Function	G-protein Coupled Receptor Binding Receptor Binding Frizzled Binding Heparin Binding
	Biological Process	Canonical Wnt Signaling Pathway Branching Involved In Labyrinthine Layer Morphogenesis Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation regulation of FZD by ubiquitination XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS		Bone mineral density ( 21533022 22504420) Intracranial volume ( 22504418) Iron status biomarkers ( 19084217) Metabolite levels ( 21909109) Renal function-related traits (BUN) ( 22797727) Waist-hip ratio ( 23563607 20935629)
Protein-protein Interactions		1 interactors: LGR4
Entrez ID		84870
HPRD ID		18181
Ensembl ID
Uniprot IDs		Q9BXY4
PDB IDs
Enriched GO Terms of Interacting Partners?		Canonical Wnt Signaling Pathway Involved In Metanephric Kidney Development Metanephric Nephron Tubule Morphogenesis Cell Differentiation Involved In Metanephros Development Metanephric Tubule Morphogenesis Metanephric Glomerulus Development Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Metanephric Nephron Tubule Development Regulation Of Branching Involved In Ureteric Bud Morphogenesis Metanephric Nephron Morphogenesis Negative Regulation Of Toll-like Receptor Signaling Pathway Male Genitalia Development Metanephric Epithelium Development Metanephros Morphogenesis Negative Regulation Of Cytokine Secretion Positive Regulation Of Kidney Development Cell Differentiation Involved In Kidney Development Metanephric Nephron Development Regulation Of Toll-like Receptor Signaling Pathway Bone Mineralization Genitalia Development Bone Remodeling Glomerulus Development Regulation Of Morphogenesis Of A Branching Structure Biomineral Tissue Development Circadian Regulation Of Gene Expression Nephron Morphogenesis Renal Tubule Morphogenesis Epithelial Cell Proliferation Canonical Wnt Signaling Pathway Renal Tubule Development Negative Regulation Of Protein Secretion Kidney Morphogenesis Metanephros Development Tissue Remodeling Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cytokine Secretion Osteoblast Differentiation Nephron Development Positive Regulation Of Wnt Signaling Pathway Kidney Epithelium Development Negative Regulation Of Secretion By Cell Circadian Rhythm Negative Regulation Of Secretion Regulation Of Organ Morphogenesis Negative Regulation Of Protein Transport Male Sex Differentiation Negative Regulation Of Cytokine Production Regulation Of Canonical Wnt Signaling Pathway Wnt Signaling Pathway Ossification
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