GEMIN2 and DHX9

Number of citations of the paper that reports this interaction (PMID 11149922)
46

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		GEMIN2	DHX9
Gene Name		gem (nuclear organelle) associated protein 2	DEAH (Asp-Glu-Ala-His) box helicase 9
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Cytoplasm Cytosol SMN Complex SMN-Sm Protein Complex Gemini Of Coiled Bodies	Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Membrane Ribonucleoprotein Complex Cytoplasmic Ribonucleoprotein Granule CRD-mediated MRNA Stability Complex
	Molecular Function	Protein Binding	RNA Polymerase II Transcription Factor Binding DNA Binding RNA Helicase Activity ATP-dependent DNA Helicase Activity ATP-dependent RNA Helicase Activity Protein Binding ATP Binding Poly(A) RNA Binding
	Biological Process	Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions Spliceosomal SnRNP Assembly MRNA Processing RNA Splicing Gene Expression NcRNA Metabolic Process	MRNA Splicing, Via Spliceosome Osteoblast Differentiation RNA Processing Circadian Rhythm RNA Splicing Gene Expression Positive Regulation Of Type I Interferon Production DNA Duplex Unwinding Cellular Response To Heat Innate Immune Response CRD-mediated MRNA Stabilization
Pathways		snRNP Assembly Metabolism of non-coding RNA	mRNA Splicing Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade RIP-mediated NFkB activation via ZBP1 DEx/H-box helicases activate type I IFN and inflammatory cytokines production Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Innate Immune System Processing of Capped Intron-Containing Pre-mRNA TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA mRNA Splicing - Major Pathway MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade TRAF6 mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS
Protein-Protein Interactions		21 interactors: DDX20 DHX9 GEMIN5 IKBKG RN7SL1 RNU1-1 RNU2-1 SMN1 SMN2 SNRNP70 SNRPD1 SNRPD2 SNRPD3 SNRPN SRSF1 SRSF2 SRSF3 SRSF4 STXBP2 STXBP3 U2AF2	40 interactors: ACTA1 AKAP8L APBB1 BRCA1 DDX20 DDX5 EIF2AK2 EWSR1 GEMIN2 GEMIN4 GTF2B H2AFX HDLBP HNRNPC HNRNPK IL7R ILF3 JUN KHDRBS1 MBD2 MGEA5 NXF1 PCNA POLR2A PRMT1 PRPF40A PRPF8 RBM4 RELA SMN1 SMN2 SNRPB SNRPB2 SRPK1 SSRP1 STAU1 TBP TOP2A UBE2I YWHAQ
Entrez ID		8487	1660
HPRD ID		03999	04386
Ensembl ID		ENSG00000092208	ENSG00000135829
Uniprot IDs		O14893	B3KU66 Q08211
PDB IDs		2LEH 3S6N	3LLM 3VYX 3VYY
Enriched GO Terms of Interacting Partners?		MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Splicing RNA Processing MRNA Processing MRNA Metabolic Process Spliceosomal SnRNP Assembly Termination Of RNA Polymerase II Transcription Ribonucleoprotein Complex Assembly RNA Metabolic Process Gene Expression DNA-templated Transcription, Termination MRNA 3'-end Processing Ribonucleoprotein Complex Biogenesis RNA 3'-end Processing Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Spliceosomal Complex Assembly MRNA Export From Nucleus Cellular Nitrogen Compound Metabolic Process RNA Export From Nucleus Nitrogen Compound Metabolic Process Cellular Macromolecular Complex Assembly Nuclear Export MRNA Transport NcRNA Metabolic Process RNA Transport RNA Localization Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Regulation Of RNA Splicing Nucleocytoplasmic Transport Nuclear Transport Cellular Component Assembly Neutrophil Degranulation Neutrophil Activation Involved In Immune Response Transcription From RNA Polymerase II Promoter Establishment Of Localization In Cell Cellular Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Neutrophil Mediated Immunity Neutrophil Activation Cytoplasmic Transport Cellular Localization Positive Regulation Of RNA Splicing Leukocyte Degranulation Regulation Of MRNA Stability Regulated Secretory Pathway	MRNA Processing RNA Splicing MRNA Metabolic Process RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Gene Expression Spliceosomal SnRNP Assembly Nitrogen Compound Metabolic Process Regulation Of Viral Process Regulation Of Viral Genome Replication Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Viral Process Positive Regulation Of DNA Metabolic Process Regulation Of Gene Expression Ribonucleoprotein Complex Assembly Viral Process Cellular Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Cellular Macromolecular Complex Assembly Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Ribonucleoprotein Complex Biogenesis Negative Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Regulation Of Metabolic Process Positive Regulation Of Metabolic Process RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Transcription Elongation From RNA Polymerase II Promoter Chromosome Organization Positive Regulation Of Response To DNA Damage Stimulus Negative Regulation Of Viral Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Viral Genome Replication
Tagcloud ?		associates atrophy characterised efficiently epitope epitopes exists explain hela immunised immuno inherited library mab mabs mansma1 mansma12 mansma3 masked motor multimeric muscular phage precipitated precise proline smn spliceosome vigorous
Tagcloud (Difference) ?		associates atrophy characterised efficiently epitope epitopes exists explain hela immunised immuno inherited library mab mabs mansma1 mansma12 mansma3 masked motor multimeric muscular phage precipitated precise proline smn spliceosome vigorous
Tagcloud (Intersection) ?