TMEM25 and RABGGTB

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		TMEM25	RABGGTB
Description		transmembrane protein 25	Rab geranylgeranyltransferase subunit beta
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Lysosome Endosome Late Endosome Plasma Membrane Membrane	Cytoplasm Cytosol Plasma Membrane Rab-protein Geranylgeranyltransferase Complex
	Molecular Function	Protein Binding	Catalytic Activity Prenyltransferase Activity Protein Geranylgeranyltransferase Activity Rab Geranylgeranyltransferase Activity Protein Binding Zinc Ion Binding Protein Prenyltransferase Activity Transferase Activity Small GTPase Binding Metal Ion Binding
	Biological Process	Regulation Of Protein Stability Negative Regulation Of Excitatory Postsynaptic Potential	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Visual Perception Protein Geranylgeranylation Protein Modification Process
Pathways			TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain RAB geranylgeranylation
Drugs			N-Formylmethionine Farnesyl diphosphate Geranylgeranyl diphosphate
Diseases
GWAS			Daytime sleep phenotypes ( 27126917) Serum metabolite levels ( 23093944)
Interacting Genes		3 interacting genes: ATXN1L GLRX3 RABGGTB	19 interacting genes: ALAS2 ARAF B4GALT7 CHML IGFBP6 NPSR1 PTP4A2 RAB11A RAB1A RAB27A RAB37 RAB3A RAB5A RAB6A RAB7A SH3GLB1 TAFA1 TMEM25 WDR4
Entrez ID		84866	5876
HPRD ID		11635	01532
Ensembl ID		ENSG00000149582	ENSG00000137955
Uniprot IDs		B7Z1M8 E9PKP3 Q86YD3	A8KAJ2 P53611 Q6IB63
PDB IDs			6J6X 6J74 6J7F 6J7X 6O60
Enriched GO Terms of Interacting Partners?		Protein Geranylgeranylation Rab-protein Geranylgeranyltransferase Complex Protein Prenyltransferase Activity Rab Geranylgeranyltransferase Activity Protein Geranylgeranyltransferase Activity Prenyltransferase Activity Protein Prenylation [2Fe-2S] Cluster Assembly Negative Regulation Of RIG-I Signaling Pathway POZ Domain Binding Positive Regulation Of Hematopoietic Stem Cell Proliferation Iron-sulfur Cluster Assembly Complex Negative Regulation Of Macrophage Cytokine Production	G Protein Activity GTPase Activity Myosin V Binding GTP Binding Endosome Establishment Of Vesicle Localization Vesicle Localization Establishment Of Organelle Localization Synaptic Vesicle Recycling Protein Transport Establishment Of Melanosome Localization Melanosome Localization Melanosome Transport Pigment Granule Transport Regulation Of Exocytosis Positive Regulation Of Exocytosis Pigment Granule Localization Establishment Of Protein Localization Nucleotide Binding Exosomal Secretion Intracellular Protein Localization Organelle Localization Synaptic Vesicle Membrane Vesicle-mediated Transport Intracellular Protein Transport Regulation Of Vesicle-mediated Transport Amyloid-beta Clearance By Transcytosis Cytoplasmic Vesicle Hydrolase Activity Presynaptic Endosome Regulation Of Neuronal Synaptic Plasticity Regulation Of Secretion Plasma Membrane To Endosome Transport Golgi Apparatus GDP Binding Endosome To Plasma Membrane Protein Transport Phagocytic Vesicle Neurotransmitter Receptor Transport Regulation Of Plasma Membrane Organization Vesicle-mediated Transport In Synapse Establishment Of Localization In Cell Secretory Granule Membrane Endosomal Transport Melanosome Transcytosis Melanosome Membrane Positive Regulation Of Secretion By Cell Early Endosome To Late Endosome Transport Regulation Of Secretion By Cell Regulation Of Regulated Secretory Pathway
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